Entry Name Bacterial secretion system - Stenotrophomonas maltophilia D457
Description Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class Environmental Information Processing; Membrane transportBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Stenotrophomonas maltophilia D457 [GN:
smz ]
Gene SMD_3531 tolC; Type I secretion outer membrane protein, TolC precursor [KO:K12340 ]
SMD_0590 xpsD; General secretion pathway protein D / Type II secretion outermembrane pore forming protein (PulD) [KO:K02453 ]
SMD_0581 xpsF; General secretion pathway protein F / Type II secretory pathway, component PulF [KO:K02455 ]
SMD_0580 xpsE; General secretion pathway protein E / Type II secretion cytoplasmic ATP binding protein (PulE, ATPase) [KO:K02454 ] [EC:7.4.2.8 ]
SMD_4168 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [KO:K02454 ] [EC:7.4.2.8 ]
SMD_1811 secD; Protein-export membrane protein SecD (TC 3.A.5.1.1) [KO:K03072 ]
SMD_1812 secF; Protein-export membrane protein SecF (TC 3.A.5.1.1) [KO:K03074 ]
SMD_0772 Preprotein translocase subunit SecE (TC 3.A.5.1.1) [KO:K03073 ]
SMD_2982 secG; Preprotein translocase subunit SecG (TC 3.A.5.1.1) [KO:K03075 ]
SMD_0805 secY; Preprotein translocase secY subunit (TC 3.A.5.1.1) [KO:K03076 ]
SMD_1810 yajC; Preprotein translocase subunit YajC (TC 3.A.5.1.1) [KO:K03210 ]
SMD_4237 yidC; Inner membrane protein translocase component YidC, long form [KO:K03217 ]
SMD_0651 secA; Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) [KO:K03070 ] [EC:7.4.2.8 ]
SMD_1743 ftsY; Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) [KO:K03110 ]
SMD_0125 secB; Protein export cytoplasm chaperone protein (SecB, maintains protein to be exported in unfolded state) [KO:K03071 ]
SMD_2635 Bores hole in peptidoglycan layer allowing type IV secretion complex assembly to occur (VirB1) [KO:K03194 ]
SMD_2634 Major pilus subunit of type IV secretion complex (VirB2) [KO:K03197 ]
SMD_2633 Inner membrane protein forms channel for type IV secretion of T-DNA complex (VirB3) [KO:K03198 ]
SMD_2638 virB9; Forms the bulk of type IV secretion complex that spans outer membrane and periplasm (VirB9) [KO:K03204 ]
SMD_2630 trwI; Integral inner membrane protein of type IV secretion complex (VirB6) [KO:K03201 ]
SMD_2639 Inner membrane protein forms channel for type IV secretion of T-DNA complex (VirB8) [KO:K03203 ]
SMD_2637 Inner membrane protein forms channel for type IV secretion of T-DNA complex (VirB10) [KO:K03195 ]
SMD_2632 virB4; ATPase provides energy for both assembly of type IV secretion complex and secretion of T-DNA complex (VirB4) [KO:K03199 ] [EC:7.4.2.8 ]
SMD_2636 virB11; ATPase provides energy for both assembly of type IV secretion complex and secretion of T-DNA complex (VirB11) [KO:K03196 ] [EC:7.4.2.8 ]
Compound Reference Authors Kim JF.
Title Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
Journal Reference Authors Plano GV, Day JB, Ferracci F.
Title Type III export: new uses for an old pathway.
Journal Reference Authors Gauthier A, Finlay BB.
Title Bacterial pathogenesis: the answer to virulence is in the pore.
Journal Reference Authors Burns DL.
Title Biochemistry of type IV secretion.
Journal Reference Authors Christie PJ, Vogel JP.
Title Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
Journal Reference Authors Christie PJ.
Title Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
Journal Reference Authors Nunn D.
Title Bacterial type II protein export and pilus biogenesis: more than just homologies?
Journal Reference Authors Sandkvist M.
Title Biology of type II secretion.
Journal Reference Authors Sandkvist M.
Title Type II secretion and pathogenesis.
Journal Reference Authors Delepelaire P
Title Type I secretion in gram-negative bacteria.
Journal Reference Authors Hazes B, Frost L
Title Towards a systems biology approach to study type II/IV secretion systems.
Journal Reference Authors Johnson TL, Abendroth J, Hol WG, Sandkvist M
Title Type II secretion: from structure to function.
Journal Reference Authors Filloux A
Title The underlying mechanisms of type II protein secretion.
Journal Reference Authors Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
Title A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
Journal Reference Authors Ghosh P
Title Process of protein transport by the type III secretion system.
Journal Reference Authors Cornelis GR
Title The Yersinia Ysc-Yop 'type III' weaponry.
Journal Reference Authors Baron C
Title VirB8: a conserved type IV secretion system assembly factor and drug target.
Journal Reference Authors Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
Title Helicobacter exploits integrin for type IV secretion and kinase activation.
Journal Reference Authors Christie PJ, Cascales E
Title Structural and dynamic properties of bacterial type IV secretion systems (review).
Journal Reference Authors Christie PJ
Title Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
Journal Reference Authors Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
Title Type V protein secretion pathway: the autotransporter story.
Journal Reference Authors Henderson IR, Navarro-Garcia F, Nataro JP
Title The great escape: structure and function of the autotransporter proteins.
Journal Reference Authors Filloux A, Hachani A, Bleves S
Title The bacterial type VI secretion machine: yet another player for protein transport across membranes.
Journal Reference Authors Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
Title Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
Journal Reference Authors Kulasekara HD, Miller SI
Title Threonine phosphorylation times bacterial secretion.
Journal Reference Authors Driessen AJ, Nouwen N
Title Protein translocation across the bacterial cytoplasmic membrane.
Journal Reference Authors Pool MR
Title Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
Journal Reference Authors Desvaux M, Hebraud M, Talon R, Henderson IR
Title Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
Journal Reference Authors Nakatogawa H, Murakami A, Ito K
Title Control of SecA and SecM translation by protein secretion.
Journal KO pathway LinkDB All DBs
