KEGG   PATHWAY: snh00260
Entry
snh00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Salvelinus namaycush (lake trout)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
snh00260  Glycine, serine and threonine metabolism
snh00260

Module
snh_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:snh00260]
snh_M00047  Creatine pathway [PATH:snh00260]
snh_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:snh00260]
snh_M00555  Betaine biosynthesis, choline => betaine [PATH:snh00260]
snh_M00621  Glycine cleavage system [PATH:snh00260]
snh_M00974  Betaine metabolism, animals, betaine => glycine [PATH:snh00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Salvelinus namaycush (lake trout) [GN:snh]
Gene
120046782  tha1; threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
120057762  shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
120055771  agxtb; alanine--glyoxylate and serine--pyruvate aminotransferase b [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
120053581  agxta; alanine--glyoxylate and serine--pyruvate aminotransferase a isoform X1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
120047481  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
120062373  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
120059058  glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
120021699  phosphoglycerate mutase 2-like [KO:K01834] [EC:5.4.2.11]
120032792  phosphoglycerate mutase 1 isoform X1 [KO:K01834] [EC:5.4.2.11]
120032861  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
120026353  phosphoglycerate mutase 2-like [KO:K01834] [EC:5.4.2.11]
120046699  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
120029856  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
120053540  bisphosphoglycerate mutase-like [KO:K01837] [EC:5.4.2.4 5.4.2.11]
120066779  bisphosphoglycerate mutase-like [KO:K01837] [EC:5.4.2.4 5.4.2.11]
120063832  D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
120058241  D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
120035334  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
120018764  phosphoserine phosphatase-like isoform X1 [KO:K01079] [EC:3.1.3.3]
120028356  phosphoserine phosphatase-like isoform X1 [KO:K01079] [EC:3.1.3.3]
120033977  2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial-like [KO:K00639] [EC:2.3.1.29]
120023318  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
120019220  tdh; L-threonine dehydrogenase [KO:K15789] [EC:1.1.1.103]
120042381  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
120059978  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
120037969  5-aminolevulinate synthase, nonspecific, mitochondrial-like isoform X1 [KO:K00643] [EC:2.3.1.37]
120058273  5-aminolevulinate synthase, nonspecific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]
120059372  alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
120061315  5-aminolevulinate synthase, nonspecific, mitochondrial-like isoform X1 [KO:K00643] [EC:2.3.1.37]
120063987  mao; amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
120058520  amine oxidase [flavin-containing] isoform X1 [KO:K00274] [EC:1.4.3.4]
120034135  membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
120037287  primary amine oxidase, liver isozyme-like [KO:K00276] [EC:1.4.3.21]
120037356  primary amine oxidase, liver isozyme-like [KO:K00276] [EC:1.4.3.21]
120063112  glycine dehydrogenase (decarboxylating), mitochondrial-like [KO:K00281] [EC:1.4.4.2]
120056914  glycine dehydrogenase (decarboxylating), mitochondrial-like [KO:K00281] [EC:1.4.4.2]
120061278  amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
120052383  dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
120066133  dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
120025128  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
120056115  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
120053466  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
120066699  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
120063286  D-amino-acid oxidase-like [KO:K00273] [EC:1.4.3.3]
120044878  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
120049950  gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
120053391  gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
120054431  guanidinoacetate N-methyltransferase-like [KO:K00542] [EC:2.1.1.2]
120059462  chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
120025785  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
120021263  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
120025679  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
120025444  dimethylglycine dehydrogenase, mitochondrial-like [KO:K00315] [EC:1.5.8.4]
120028637  pipox; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
120026194  sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
120025133  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
120064180  cystathionine beta-synthase-like isoform X1 [KO:K01697] [EC:4.2.1.22]
120051527  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
120051537  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
120058470  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
120053747  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
120054707  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
120045852  L-threonine dehydratase catabolic TdcB [KO:K01754] [EC:4.3.1.19]
120062650  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
120051212  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
120060424  sdsl; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
snh00010  Glycolysis / Gluconeogenesis
snh00020  Citrate cycle (TCA cycle)
snh00230  Purine metabolism
snh00250  Alanine, aspartate and glutamate metabolism
snh00270  Cysteine and methionine metabolism
snh00290  Valine, leucine and isoleucine biosynthesis
snh00330  Arginine and proline metabolism
snh00470  D-Amino acid metabolism
snh00564  Glycerophospholipid metabolism
snh00600  Sphingolipid metabolism
snh00620  Pyruvate metabolism
snh00630  Glyoxylate and dicarboxylate metabolism
snh00640  Propanoate metabolism
snh00860  Porphyrin metabolism
snh00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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