KEGG   PATHWAY: spsy02010
Entry
spsy02010                   Pathway                                
Name
ABC transporters - Sporosarcina psychrophila
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
spsy02010  ABC transporters
spsy02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Sporosarcina psychrophila [GN:spsy]
Gene
AZE41_18035  sulfate transporter subunit [KO:K23163]
AZE41_18030  sulfate ABC transporter permease subunit CysT [KO:K02046]
AZE41_18025  sulfate ABC transporter permease subunit CysW [KO:K02047]
AZE41_18020  sulfate ABC transporter [KO:K02045] [EC:7.3.2.3]
AZE41_10495  nitrate ABC transporter substrate-binding protein [KO:K15553]
AZE41_10490  ABC transporter permease [KO:K15554]
AZE41_10485  nitrate/sulfonate/bicarbonate ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
AZE41_07275  ABC transporter substrate-binding protein [KO:K15598]
AZE41_07280  ABC transporter permease [KO:K15599]
AZE41_07285  ABC transporter ATP-binding protein [KO:K15600]
AZE41_01610  molybdate ABC transporter substrate-binding protein [KO:K02020]
AZE41_01615  molybdenum ABC transporter permease subunit [KO:K02018]
AZE41_01620  ABC transporter [KO:K02017] [EC:7.3.2.5]
AZE41_18010  iron ABC transporter substrate-binding protein [KO:K02012]
AZE41_01075  ABC transporter substrate-binding protein [KO:K02012]
AZE41_18000  iron ABC transporter permease [KO:K02011]
AZE41_01070  iron ABC transporter permease [KO:K02011]
AZE41_18005  spermidine/putrescine ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
AZE41_01065  ABC transporter [KO:K02010] [EC:7.2.2.7]
AZE41_16375  spermidine/putrescine ABC transporter substrate-binding protein [KO:K11069]
AZE41_16370  spermidine/putrescine ABC transporter permease [KO:K11070]
AZE41_16365  spermidine/putrescine ABC transporter permease [KO:K11071]
AZE41_16360  spermidine/putrescine ABC transporter ATP-binding protein [KO:K11072] [EC:7.6.2.11]
AZE41_06795  glycine/betaine ABC transporter [KO:K02002]
AZE41_15830  glycine/betaine ABC transporter [KO:K02002]
AZE41_06790  glycine/betaine ABC transporter [KO:K02001]
AZE41_06785  glycine betaine/L-proline ABC transporter ATP-binding protein [KO:K02000] [EC:7.6.2.9]
AZE41_02305  glycine/betaine ABC transporter substrate-binding protein [KO:K05845]
AZE41_20385  glycine/betaine ABC transporter substrate-binding protein [KO:K05845]
AZE41_21060  glycine/betaine ABC transporter substrate-binding protein [KO:K05845]
AZE41_02300  glycine/betaine ABC transporter [KO:K05846]
AZE41_21055  amino acid ABC transporter permease [KO:K05846]
AZE41_21065  choline ABC transporter permease [KO:K05846]
AZE41_20380  glycine/betaine ABC transporter [KO:K05846]
AZE41_02295  glycine/betaine ABC transporter ATP-binding protein [KO:K05847] [EC:7.6.2.9]
AZE41_20375  proline/glycine betaine ABC transporter ATP-binding protein [KO:K05847] [EC:7.6.2.9]
AZE41_21070  glycine/betaine ABC transporter ATP-binding protein [KO:K05847] [EC:7.6.2.9]
AZE41_10090  sugar ABC transporter ATP-binding protein [KO:K10112] [EC:7.5.2.-]
AZE41_10050  ABC transporter substrate-binding protein [KO:K10117]
AZE41_10055  ABC transporter permease [KO:K10118]
AZE41_10060  sugar ABC transporter permease [KO:K10119]
AZE41_08435  sugar ABC transporter substrate-binding protein [KO:K10546]
AZE41_08445  ABC transporter permease [KO:K10547]
AZE41_08440  ABC transporter ATP-binding protein [KO:K10548] [EC:7.5.2.-]
AZE41_15245  hypothetical protein [KO:K07335]
AZE41_17565  ABC transporter substrate-binding protein [KO:K07335]
AZE41_15235  branched-chain amino acid ABC transporter permease [KO:K23535]
AZE41_15230  sugar ABC transporter permease [KO:K23536]
AZE41_15240  heme ABC transporter ATP-binding protein [KO:K23537]
AZE41_08450  sugar ABC transporter substrate-binding protein [KO:K10439]
AZE41_19095  LacI family transcriptional regulator [KO:K10439]
AZE41_17780  D-ribose ABC transporter substrate-binding protein [KO:K10439]
AZE41_19085  ribose ABC transporter permease [KO:K10440]
AZE41_17785  rbsC; ribose ABC transporter permease [KO:K10440]
AZE41_17790  D-ribose transporter ATP-binding protein [KO:K10441] [EC:7.5.2.7]
AZE41_19090  lantibiotic ABC transporter permease [KO:K10441] [EC:7.5.2.7]
AZE41_17795  D-ribose pyranase [KO:K06726] [EC:5.4.99.62]
AZE41_08465  D-xylose ABC transporter substrate-binding protein [KO:K10543]
AZE41_17650  glycerol-3-phosphate ABC transporter substrate-binding protein [KO:K05813]
AZE41_17660  glycerol-3-phosphate ABC transporter permease [KO:K05814]
AZE41_17655  glycerol-3-phosphate ABC transporter permease [KO:K05815]
AZE41_17665  glycerol-3-phosphate ABC transporter ATP-binding protein [KO:K05816] [EC:7.6.2.10]
AZE41_03340  phosphate ABC transporter substrate-binding protein [KO:K02040]
AZE41_01735  phosphate-binding protein [KO:K02040]
AZE41_03345  phosphate ABC transporter permease subunit PstC [KO:K02037]
AZE41_01730  phosphate ABC transporter permease subunit PstC [KO:K02037]
AZE41_03350  phosphate ABC transporter, permease protein PstA [KO:K02038]
AZE41_01725  phosphate ABC transporter, permease protein PstA [KO:K02038]
AZE41_03355  pstB; phosphate ABC transporter ATP-binding protein [KO:K02036] [EC:7.3.2.1]
AZE41_01720  pstB; phosphate ABC transporter ATP-binding protein [KO:K02036] [EC:7.3.2.1]
AZE41_06245  amino acid ABC transporter substrate-binding protein [KO:K10036]
AZE41_06250  amino acid ABC transporter permease [KO:K10037]
AZE41_06255  peptide ABC transporter ATP-binding protein [KO:K10038] [EC:7.4.2.1]
AZE41_16760  amino acid ABC transporter substrate-binding protein [KO:K10039]
AZE41_16750  glutamine ABC transporter permease [KO:K10040]
AZE41_16755  glutamine ABC transporter permease [KO:K10040]
AZE41_16765  polar amino acid ABC transporter ATP-binding protein [KO:K10041] [EC:7.4.2.1]
AZE41_10375  glutamine ABC transporter substrate-bindnig protein [KO:K02424]
AZE41_10590  amino acid ABC transporter substrate-binding protein [KO:K02424]
AZE41_06820  amino acid ABC transporter substrate-binding protein [KO:K02424]
AZE41_10385  ABC transporter permease [KO:K10009]
AZE41_10595  cysteine ABC transporter permease [KO:K10009]
AZE41_06825  cysteine ABC transporter permease [KO:K10009]
AZE41_06830  ectoine/hydroxyectoine ABC transporter ATP-binding protein EhuA [KO:K10010] [EC:7.4.2.1]
AZE41_10390  ectoine/hydroxyectoine ABC transporter ATP-binding protein EhuA [KO:K10010] [EC:7.4.2.1]
AZE41_10400  amino acid ABC transporter substrate-binding protein [KO:K16957]
AZE41_10405  amino acid ABC transporter permease [KO:K16958]
AZE41_10410  amino acid ABC transporter permease [KO:K16959]
AZE41_10415  amino acid ABC transporter ATP-binding protein [KO:K16960] [EC:7.4.2.1]
AZE41_09535  ABC transporter substrate-binding protein [KO:K23059]
AZE41_09530  arginine ABC transporter permease [KO:K17077]
AZE41_09525  peptide ABC transporter ATP-binding protein [KO:K23060] [EC:7.4.2.1]
AZE41_04980  ethanolamine utilization protein EutJ [KO:K01999]
AZE41_09625  branched chain amino acid ABC transporter substrate-binding protein [KO:K01999]
AZE41_11435  hypothetical protein [KO:K01999]
AZE41_21120  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
AZE41_04985  ABC transporter permease [KO:K01997]
AZE41_09630  ABC transporter permease [KO:K01997]
AZE41_11425  hypothetical protein [KO:K01997]
AZE41_21115  ABC transporter permease [KO:K01997]
AZE41_11420  hypothetical protein [KO:K01995 K01998]
AZE41_04990  ABC transporter [KO:K01998]
AZE41_21110  amino acid ABC transporter [KO:K01998]
AZE41_09635  branched-chain amino acid ABC transporter permease [KO:K01998]
AZE41_04995  livG; ABC transporter ATP-binding protein [KO:K01995]
AZE41_09640  ABC transporter ATP-binding protein [KO:K01995]
AZE41_21105  ABC transporter ATP-binding protein [KO:K01995]
AZE41_05000  ABC transporter ATP-binding protein [KO:K01996]
AZE41_21100  ABC transporter ATP-binding protein [KO:K01996]
AZE41_11415  ABC transporter ATP-binding protein [KO:K01996]
AZE41_09645  ABC transporter ATP-binding protein [KO:K01996]
AZE41_00385  methionine ABC transporter substrate-binding protein [KO:K02073]
AZE41_04915  methionine ABC transporter substrate-binding protein [KO:K02073]
AZE41_04920  methionine ABC transporter substrate-binding protein [KO:K02073]
AZE41_06910  hypothetical protein [KO:K02073]
AZE41_00390  ABC transporter permease [KO:K02072]
AZE41_04910  methionine ABC transporter permease [KO:K02072]
AZE41_06905  methionine ABC transporter permease [KO:K02072]
AZE41_00395  phosphate ABC transporter ATP-binding protein [KO:K02071]
AZE41_04905  methionine ABC transporter ATP-binding protein [KO:K02071]
AZE41_06900  methionine ABC transporter ATP-binding protein [KO:K02071]
AZE41_16935  peptide ABC transporter substrate-binding protein [KO:K15580]
AZE41_14245  peptide ABC transporter substrate-binding protein [KO:K15580]
AZE41_16930  peptide ABC transporter permease [KO:K15581]
AZE41_14240  peptide ABC transporter permease [KO:K15581]
AZE41_16925  peptide ABC transporter permease [KO:K15582]
AZE41_14235  peptide ABC transporter permease [KO:K15582]
AZE41_16920  peptide ABC transporter ATP-binding protein [KO:K15583]
AZE41_14230  peptide ABC transporter ATP-binding protein [KO:K15583]
AZE41_16915  peptide ABC transporter ATP-binding protein [KO:K10823]
AZE41_14225  peptide ABC transporter ATP-binding protein [KO:K10823]
AZE41_21155  nickel ABC transporter substrate-binding protein [KO:K15584]
AZE41_21160  nickel ABC transporter permease subunit NikB [KO:K15585]
AZE41_21165  nickel ABC transporter permease subunit NikC [KO:K15586]
AZE41_21170  nickel import ATP-binding protein NikD [KO:K15587] [EC:7.2.2.11]
AZE41_21175  peptide ABC transporter ATP-binding protein [KO:K10824] [EC:7.2.2.11]
AZE41_08385  iron ABC transporter permease [KO:K25286]
AZE41_08380  iron ABC transporter [KO:K23186]
AZE41_08375  iron ABC transporter [KO:K23187]
AZE41_08370  iron dicitrate ABC transporter ATP-binding protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
AZE41_21695  ferrichrome ABC transporter substrate-binding protein [KO:K23227]
AZE41_21690  iron ABC transporter permease [KO:K23228]
AZE41_07270  manganese ABC transporter substrate-binding protein [KO:K19975]
AZE41_07265  manganese ABC transporter permease [KO:K19976]
AZE41_07260  manganese transporter [KO:K19973] [EC:7.2.2.5]
AZE41_05390  adhesin [KO:K09815]
AZE41_13165  metal ABC transporter permease [KO:K09816]
AZE41_13170  zinc ABC transporter ATP-binding protein [KO:K09817] [EC:7.2.2.20]
AZE41_01260  BioY family transporter [KO:K03523]
AZE41_14260  BioY family transporter [KO:K03523]
AZE41_17550  cobalt ABC transporter permease [KO:K16785]
AZE41_01590  cobalt ABC transporter permease [KO:K16785]
AZE41_01580  cbiO; energy-coupling factor transporter ATPase [KO:K16786] [EC:7.-.-.-]
AZE41_01585  cbiO; energy-coupling factor transporter ATPase [KO:K16787] [EC:7.-.-.-]
AZE41_10645  ABC transporter [KO:K11051]
AZE41_10650  ABC transporter [KO:K11050]
AZE41_10360  ABC transporter permease [KO:K09813]
AZE41_10355  hemin ABC transporter ATP-binding protein [KO:K09814] [EC:7.6.2.-]
AZE41_20355  cell division protein FtsX [KO:K11632]
AZE41_20360  bacitracin ABC transporter ATP-binding protein [KO:K11631]
AZE41_14920  permease [KO:K20460]
AZE41_14925  hypothetical protein [KO:K20461]
AZE41_14915  bacitracin ABC transporter ATP-binding protein [KO:K20459]
AZE41_17100  cell division protein FtsX [KO:K09811]
AZE41_17105  cell division ATP-binding protein FtsE [KO:K09812]
AZE41_02150  macrolide ABC transporter permease [KO:K16918]
AZE41_02145  ABC transporter ATP-binding protein [KO:K16920]
AZE41_03950  multidrug ABC transporter ATP-binding protein [KO:K18889]
AZE41_11095  multidrug ABC transporter ATP-binding protein [KO:K18889]
AZE41_03955  ABC transporter ATP-binding protein [KO:K18890]
AZE41_11100  multidrug ABC transporter ATP-binding protein [KO:K18890]
AZE41_20060  multidrug ABC transporter permease [KO:K18104] [EC:7.6.2.2]
AZE41_11370  multidrug ABC transporter ATP-binding protein [KO:K18887]
AZE41_02900  multidrug ABC transporter ATP-binding protein [KO:K18887]
AZE41_19955  ABC transporter ATP-binding protein [KO:K18887]
AZE41_11365  ABC transporter [KO:K18888]
AZE41_02905  multidrug ABC transporter ATP-binding protein [KO:K18888]
AZE41_19950  multidrug ABC transporter ATP-binding protein [KO:K18888]
AZE41_14660  thiol reductant ABC exporter subunit CydC [KO:K16012]
AZE41_14665  thiol reductant ABC exporter subunit CydD [KO:K16013]
AZE41_01035  ABC transporter ATP-binding protein [KO:K18231]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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