KEGG   PATHWAY: spt02010
Entry
spt02010                    Pathway                                
Name
ABC transporters - Salmonella enterica subsp. enterica serovar Paratyphi A ATCC9150
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
spt02010  ABC transporters
spt02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Salmonella enterica subsp. enterica serovar Paratyphi A ATCC9150 [GN:spt]
Gene
SPA0422  cysP; thiosulphate-binding protein precursor [KO:K02048]
SPA3906  sbp; periplasmic sulphate binding protein [KO:K23163]
SPA0423  cysU; sulphate transport system permease protein CysT [KO:K02046]
SPA0424  cysW; sulphate transport system permease protein CysW [KO:K02047]
SPA0425  cysA; sulphate transport ATP-binding protein CysA [KO:K02045] [EC:7.3.2.3]
SPA1971  modA; molybdate-binding periplasmic protein precursor [KO:K02020]
SPA3009  hypothetical protein [KO:K02020]
SPA1970  modB; molybdenum transport system permease protein ModB [KO:K02018]
SPA1969  modC; molybdenum transport ATP-binding protein ModC [KO:K02017] [EC:7.3.2.5]
SPA1974  modF; putative molybdenum transport ATP-binding protein ModF (photorepair protein PhrA) [KO:K05776]
SPA0110  tbpA; thiamine-binding periplasmic protein precursor [KO:K02064]
SPA0109  yabK; putative ABC transporter integral membrane protein [KO:K02063]
SPA0108  yabJ; hypothetical ABC transporter [KO:K02062] [EC:7.6.2.15]
SPA1628  potD; spermidine/putrescine-binding periplasmic protein precursor [KO:K11069]
SPA1627  potC; spermidine/putrescine transport system permease protein PotC [KO:K11070]
SPA1625  potB; spermidine/putrescine transport system permease protein PotB [KO:K11071]
SPA1624  potA; spermidine/putrescine transport ATP-binding protein PotA (ABC superfamily) [KO:K11072] [EC:7.6.2.11]
SPA1885  potF; putrescine-binding periplasmic protein precursor [KO:K11073]
SPA1882  potI; putrescine transport system permease protein PotI [KO:K11074]
SPA1883  potH; putrescine transport system permease protein PotH [KO:K11075]
SPA1884  potG; putrescine transport ATP-binding protein PotG [KO:K11076] [EC:7.6.2.16]
SPA2294  phnS; probable periplasmic binding component of 2-aminoethylphosphonate transporter [KO:K11081]
SPA2297  phnV; probable membrane component of 2-aminoethylphosphonate transporter [KO:K11082]
SPA2296  phnU; probable membrane component of 2-aminoethylphosphonate transporter [KO:K11083]
SPA2295  phnT; probable ATP-binding component of 2-aminoethylphosphonate transporter [KO:K11084]
SPA2669  proX; glycine betaine-binding periplasmic protein precursor [KO:K02002]
SPA2668  proW; glycine betaine/L-proline transport system permease protein P [KO:K02001]
SPA2667  proV; ABC superfamily (atp_bind), glycine/betaine/proline transport protein [KO:K02000] [EC:7.6.2.9]
SPA0686  yehZ; putative periplasmic protein [KO:K05845]
SPA1361  putative ABC transporter periplasmic binding protein [KO:K05845]
SPA0687  yehY; putative permease transmembrane component [KO:K05846]
SPA0689  yehW; putative permease transmembrane component [KO:K05846]
SPA1360  putative ABC transporter membrane protein [KO:K05846]
SPA1362  putative ABC transporter membrane protein [KO:K05846]
SPA0688  yehX; ABC transporter ATP-binding protein [KO:K05847] [EC:7.6.2.9]
SPA1363  putative ABC transporter ATP/GTP-binding protein [KO:K05847] [EC:7.6.2.9]
SPA4046  malE; periplasmic maltose-binding protein [KO:K10108]
SPA4045  malF; maltose transport inner membrane protein [KO:K10109]
SPA4044  malG; maltose transport inner membrane protein [KO:K10110]
SPA4047  malK; maltose/maltodextrin transport ATP-binding protein [KO:K10111] [EC:7.5.2.-]
SPA3177  yrbC; possible exported protein [KO:K07323]
SPA3178  yrbD; possible exported protein [KO:K02067]
SPA3179  yrbE; putative membrane protein [KO:K02066]
SPA3176  yrbB; possible anti-sigma factor antagonist [KO:K07122]
SPA3180  yrbF; possible ABC-transport protein, ATP-binding component [KO:K02065]
SPA3723  rbsB; D-ribose-binding periplasmic protein [KO:K10439]
SPA3721  rbsA; high affinity ribose transport protein [KO:K10441] [EC:7.5.2.7]
SPA3720  rbsD; high affinity ribose transport protein RbsD [KO:K06726] [EC:5.4.99.62]
SPA0661  mglB; D-galactose-binding periplasmic protein precursor [KO:K10540]
SPA0663  mglC; galactoside transport system permease protein MglC [KO:K10541]
SPA3409  ugpB; glycerol-3-phosphate-binding periplasmic protein [KO:K05813]
SPA3408  ugpA; glycerol-3-phosphate transport system permease protein [KO:K05814]
SPA3407  ugpE; sn-Glycerol-3-phosphate transport system permease protein [KO:K05815]
SPA3406  ugpC; sn-Glycerol-3-phosphate transport ATP-binding protein [KO:K05816] [EC:7.6.2.10]
SPA3698  pstS; periplasmic phosphate-binding protein [KO:K02040]
SPA3697  pstC; phosphate transport system permease protein [KO:K02037]
SPA3696  pstA; phosphate transport system permease protein [KO:K02038]
SPA3695  pstB; phosphate transport ATP-binding protein [KO:K02036] [EC:7.3.2.1]
SPA0509  argT; lysine-arginine-ornithine-binding periplasmic protein precursor [KO:K10013]
SPA0512  hisM; histidine transport system permease [KO:K10015]
SPA0511  hisQ; histidine transport system permease protein [KO:K10016]
SPA0513  hisP; histidine transport ATP-binding protein [KO:K10017] [EC:7.4.2.1]
SPA0510  hisJ; histidine-binding periplasmic protein [KO:K10014]
SPA1923  glnH; glutamine-binding periplasmic protein precursor [KO:K10036]
SPA1924  glnP; glutamine transport system permease protein GlnP [KO:K10037]
SPA1925  glnQ; glutamine transport ATP-binding protein GlnQ [KO:K10038] [EC:7.4.2.1]
SPA1875  artJ; arginine-binding periplasmic protein [KO:K09996]
SPA4168  artJ; arginine-binding periplasmic protein [KO:K09996]
SPA1872  artI; arginine-binding periplasmic protein 1 precursor [KO:K09997]
SPA1874  artM; arginine transport system permease protein ArtM [KO:K09998]
SPA1873  artQ; arginine transport system permease protein ArtQ [KO:K09999]
SPA1871  artP; arginine transport ATP-binding protein ArtP [KO:K10000] [EC:7.4.2.1]
SPA2075  ybeJ; ABC transporter periplasmic binding protein [KO:K10001]
SPA2077  gltK; glutamate/aspartate transport system permease protein GltK [KO:K10002]
SPA2076  gltJ; glutamate/aspartate transport system permease protein GltJ [KO:K10003]
SPA2078  gltL; glutamate/aspartate transport ATP-binding protein GltL [KO:K10004] [EC:7.4.2.1]
SPA0915  fliY; cystine-binding periplasmic protein precursor [KO:K02424]
SPA0917  yecS; putative ABC transporter membrane protein [KO:K10009]
SPA0918  yecC; putative ABC transport ATP-binding protein [KO:K10010] [EC:7.4.2.1]
SPA3415  livK; leucine-specific binding protein [KO:K01999]
SPA3418  livJ; ABC superfamily (bind_prot), branched-chain amino acid transporter, high-affinity [KO:K01999]
SPA3414  livH; high-affinity branched-chain amino acid transport system permease protein [KO:K01997]
SPA3413  livM; high-affinity branched-chain amino acid transport system permease protein [KO:K01998]
SPA3412  livG; high-affinity branched-chain amino acid transport ATP-binding protein [KO:K01995]
SPA3411  livF; high-affinity branched-chain amino acid transport ATP-binding protein [KO:K01996]
SPA0252  yaeC; putative lipoprotein precursor [KO:K02073]
SPA2212  sfbA; lipoprotein [KO:K02073]
SPA0253  yaeE; putative ABC transporter permease protein [KO:K02072]
SPA2210  sfbC; ABC transporter integral membrane protein [KO:K02072]
SPA0254  abc; putative ABC transporter ATP-binding protein [KO:K02071]
SPA2211  sfbB; ABC transporter ATP-binding protein [KO:K02071]
SPA1131  oppA; periplasmic oligopeptide-binding protein precursor [KO:K15580]
SPA1205  mppA; periplasmic murein peptide-binding protein MppA [KO:K15580]
SPA1132  oppB; oligopeptide transport system permease protein OppB [KO:K15581]
SPA1133  oppC; ABC superfamily (membrane), oligopeptide transport protein [KO:K15582]
SPA1134  oppD; oligopeptide transport ATP-binding protein OppD [KO:K15583]
SPA1135  oppF; oligopeptide transport ATP-binding protein OppF [KO:K10823]
SPA3487  dppA; periplasmic dipeptide transport protein precursor [KO:K12368]
SPA3486  dppB; dipeptide transport system permease protein DppB [KO:K12369]
SPA3485  dppC; dipeptide transport system permease protein DppC [KO:K12370]
SPA3484  dppD; dipeptide transport ATP-binding protein DppD [KO:K12371]
SPA3483  dppF; dipeptide transport ATP-binding protein DppF [KO:K12372]
SPA1192  sapA; peptide transport periplasmic protein SapA precursor [KO:K19226]
SPA1191  sapB; peptide transport system permease protein SapB [KO:K19227]
SPA1182  sapC; peptide transport system permease protein SapC [KO:K19228]
SPA1181  sapD; peptide transport system ATP-binding protein SapD [KO:K19229]
SPA1180  sapF; peptide transport system ATP-binding protein SapF [KO:K19230]
SPA1906  yliB; putative ABC transporter periplasmic binding protein [KO:K13889]
SPA1905  yliC; hypothetical ABC transporter permease protein [KO:K13890]
SPA1904  yliD; hypothetical ABC transporter permease protein [KO:K13891]
SPA1907  yliA; hypothetical ABC transporter ATP-binding protein [KO:K13892]
SPA0635  yejA; putative transport system periplasmic binding protein [KO:K13893]
SPA0634  yejB; putative binding-protein-dependent transporter [KO:K13894]
SPA0633  yejE; putative binding-protein-dependent transporter [KO:K13895]
SPA0632  yejF; putative ABC-transporter ATP-binding protein [KO:K13896]
SPA2140  fepB; ferrienterobactin-binding periplasmic protein precursor [KO:K23185]
SPA2142  fepD; ferric enterobactin transport protein FepD [KO:K23186]
SPA2143  fepG; ferric enterobactin transport protein FepG [KO:K23187]
SPA2144  fepC; ferric enterobactin transport ATP-binding protein FepC [KO:K23188] [EC:7.2.2.17 7.2.2.-]
SPA0199  fhuD; ferrichrome-binding periplasmic protein precursor [KO:K23227]
SPA0200  fhuB; ferrichrome transport protein FhuB precursor [KO:K23228]
SPA0198  fhuC; ferrichrome transport ATP-binding protein FhuC [KO:K10829] [EC:7.2.2.16]
SPA0212  btuF; cobalamin periplasmic binding protein [KO:K06858]
SPA1503  btuC; vitamin B12 transport system permease [KO:K06073]
SPA1501  btuD; vitamin B12 ABC transport ATP-binding protein [KO:K06074] [EC:7.6.2.8]
SPA0978  yebL; high-affinity zinc uptake system periplasmic binding protein [KO:K09815]
SPA0976  yebI; high-affinity zinc uptake system membrane protein [KO:K09816]
SPA0977  znuC; high-affinity zinc uptake system ATP-binding protein [KO:K09817] [EC:7.2.2.20]
SPA2719  sitA; Iron transport protein, periplasmic-binding protein [KO:K11604]
SPA2721  sitC; Iron transport protein, inner membrane component [KO:K11605]
SPA2722  sitD; Iron transport protein, inner membrane component [KO:K11606]
SPA2720  sitB; Iron transport protein, ATP-binding component [KO:K11607]
SPA0849  cbiN; putative cobalt transport protein CbiN [KO:K02009]
SPA0848  cbiM; synthesis of vitamin B12 adenosyl cobalamide precursor [KO:K02007]
SPA0850  cbiQ; putative cobalt transport protein CbiQ [KO:K02008]
SPA0851  cbiO; putative cobalt transport ATP-binding protein CbiO [KO:K02006]
SPA2944  putative membrane protein [KO:K16785]
SPA2945  possible ABC-transport protein, ATP-binding component [KO:K16786] [EC:7.-.-.-]
SPA2946  possible ABC-transport protein, ATP-binding component [KO:K16787] [EC:7.-.-.-]
SPA3920  yneA; putative ABC transport protein, solute-binding component [KO:K10555]
SPA3918  ydeY; putative ABC transporter permease protein [KO:K10556]
SPA3919  ydeZ; putative ABC transporter, membrane component [KO:K10557]
SPA3917  ego; putative ABC transporter ATP-binding protein [KO:K10558]
SPA2020  putative polysaccharide export ABC transporter ATP-binding protein [KO:K09691] [EC:7.5.2.14]
SPA1633  ycfU; ABC transporter integral membrane subunit [KO:K09808]
SPA1631  ycfW; ABC transporter integral membrane subunit [KO:K09808]
SPA1632  ycfV; ABC transporter ATP-binding subunit [KO:K09810] [EC:7.6.2.-]
SPA0613  ccmD; heme exporter protein D1 [KO:K02196]
SPA3666  ccmD; heme exporter protein D1 [KO:K02196]
SPA0612  ccmC; heme exporter protein C1 [KO:K02195]
SPA3667  ccmC; heme exporter protein C1 [KO:K02195]
SPA0611  ccmB; heme exporter protein B1 [KO:K02194]
SPA3668  ccmB; heme exporter protein B1 [KO:K02194]
SPA0610  ccmA; heme exporter protein A1 [KO:K02193] [EC:7.6.2.5]
SPA3669  ccmA; heme exporter protein A1 [KO:K02193] [EC:7.6.2.5]
SPA4279  yjgP; putative inner membrane protein [KO:K07091]
SPA4280  yjgQ; putative inner membrane protein [KO:K11720]
SPA3186  yhbG; probable ABC transport protein, ATP-binding component [KO:K06861] [EC:7.5.2.5]
SPA3420  ftsX; cell division protein [KO:K09811]
SPA3421  ftsE; cell division ATP-binding protein FtsE [KO:K09812]
SPA1814  msbA; probable transport ATP-binding protein MsbA [KO:K11085] [EC:7.5.2.6]
SPA2262  mdlA; putative ABC transporter ATP-binding membrane protein [KO:K18889]
SPA2261  mdlB; putative ABC transporter ATP-binding membrane protein [KO:K18890]
SPA2630  iroC; putative ABC transporter protein [KO:K18895]
SPA2550  putative type I secretion protein, ATP-binding protein [KO:K12541]
SPA4078  putative type-1 secretion protein [KO:K12541]
SPA1842  cydC; transport ATP-binding protein CydC [KO:K16012]
SPA1841  cydD; transport ATP-binding protein CydD [KO:K16013]
SPA1857  ybjZ; conserved hypothetical ABC transporter [KO:K05685] [EC:7.6.2.-]
SPA0601  yojI; putative ABC transporter ATP-binding protein [KO:K06159]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
LinkDB

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