KEGG   PATHWAY: srz00260
Entry
srz00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Serratia rubidaea
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
srz00260  Glycine, serine and threonine metabolism
srz00260

Module
srz_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:srz00260]
srz_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:srz00260]
srz_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:srz00260]
srz_M00555  Betaine biosynthesis, choline => betaine [PATH:srz00260]
srz_M00621  Glycine cleavage system [PATH:srz00260]
srz_M00919  Ectoine degradation, ectoine => aspartate [PATH:srz00260]
srz_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:srz00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Serratia rubidaea [GN:srz]
Gene
AXX16_0927  Aspartokinase [KO:K00928] [EC:2.7.2.4]
AXX16_4480  Aspartokinase / Homoserine dehydrogenase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
AXX16_0680  Aspartokinase / Homoserine dehydrogenase [KO:K12525] [EC:2.7.2.4 1.1.1.3]
AXX16_0769  Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AXX16_4479  Homoserine kinase [KO:K00872] [EC:2.7.1.39]
AXX16_4478  Threonine synthase [KO:K01733] [EC:4.2.3.1]
AXX16_3518  Low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
AXX16_2041  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AXX16_1676  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AXX16_2569  D-3-phosphoglycerate dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
AXX16_0509  2-ketogluconate 6-phosphate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
AXX16_4352  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
AXX16_4036  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
AXX16_3876  Phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
AXX16_4485  Phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
AXX16_0431  Phosphoglycerate mutase family [KO:K15634] [EC:5.4.2.11]
AXX16_0647  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
AXX16_3566  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AXX16_1425  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AXX16_3485  Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
AXX16_4496  Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
AXX16_2774  3-hydroxypropionate dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
AXX16_0643  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
AXX16_0644  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
AXX16_1434  Glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
AXX16_1432  Aminomethyltransferase (glycine cleavage system T protein) [KO:K00605] [EC:2.1.2.10]
AXX16_1340  Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex [KO:K00382] [EC:1.8.1.4]
AXX16_1433  Glycine cleavage system H protein [KO:K02437]
AXX16_1592  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
AXX16_3659  Choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
AXX16_3660  Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AXX16_2056  GbcA Glycine betaine demethylase subunit A [KO:K00479] [EC:1.14.13.251]
AXX16_2058  GbcB Glycine betaine demethylase subunit B [KO:K21832] [EC:1.14.13.251]
AXX16_2052  DgcA Dimethylglycine demethylase subunit A [KO:K21833] [EC:1.5.7.3]
AXX16_2053  putative L-lactate dehydrogenase, Iron-sulfur cluster-binding subunit YkgF [KO:K21834]
AXX16_2054  Electron transfer flavoprotein, alpha subunit [KO:K25960]
AXX16_2055  Electron transfer flavoprotein, beta subunit [KO:K25961]
AXX16_2038  Sarcosine oxidase alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
AXX16_2040  Sarcosine oxidase beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
AXX16_2037  Sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
AXX16_2039  Sarcosine oxidase delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
AXX16_3555  Cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
AXX16_3556  Cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
AXX16_2421  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
AXX16_2046  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
AXX16_3553  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
AXX16_0714  Threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]
AXX16_0517  Threonine dehydratase, catabolic [KO:K01754] [EC:4.3.1.19]
AXX16_2862  Threonine dehydratase, catabolic [KO:K01754] [EC:4.3.1.19]
AXX16_2929  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
AXX16_2131  low-specificity D-threonine aldolase [KO:K01753] [EC:4.3.1.18]
AXX16_1879  Aspartate racemase [KO:K25316] [EC:5.1.1.10]
AXX16_2702  Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
AXX16_2703  Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
AXX16_2930  Siderophore biosynthesis diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
AXX16_2855  Diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
AXX16_2856  L-2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
AXX16_2864  Xaa-Pro aminopeptidase [KO:K15783] [EC:3.5.4.44]
AXX16_2865  succinate dehydrogenase subunit [KO:K15784] [EC:3.5.1.125]
AXX16_2861  Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase [KO:K15785] [EC:2.6.1.76]
AXX16_2860  Succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
srz00010  Glycolysis / Gluconeogenesis
srz00020  Citrate cycle (TCA cycle)
srz00230  Purine metabolism
srz00250  Alanine, aspartate and glutamate metabolism
srz00270  Cysteine and methionine metabolism
srz00290  Valine, leucine and isoleucine biosynthesis
srz00300  Lysine biosynthesis
srz00330  Arginine and proline metabolism
srz00460  Cyanoamino acid metabolism
srz00470  D-Amino acid metabolism
srz00564  Glycerophospholipid metabolism
srz00600  Sphingolipid metabolism
srz00620  Pyruvate metabolism
srz00630  Glyoxylate and dicarboxylate metabolism
srz00640  Propanoate metabolism
srz00680  Methane metabolism
srz00860  Porphyrin metabolism
srz00920  Sulfur metabolism
KO pathway
ko00260   
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