KEGG   PATHWAY: sspn00260
Entry
sspn00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Streptomyces spinosirectus
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sspn00260  Glycine, serine and threonine metabolism
sspn00260

Module
sspn_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sspn00260]
sspn_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sspn00260]
sspn_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:sspn00260]
sspn_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:sspn00260]
sspn_M00555  Betaine biosynthesis, choline => betaine [PATH:sspn00260]
sspn_M00621  Glycine cleavage system [PATH:sspn00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptomyces spinosirectus [GN:sspn]
Gene
LXH13_19530  aspartate kinase [KO:K00928] [EC:2.7.2.4]
LXH13_14770  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
LXH13_19525  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
LXH13_27040  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
LXH13_27050  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
LXH13_22690  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
LXH13_27045  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
LXH13_04300  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
LXH13_16695  glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
LXH13_27095  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
LXH13_27660  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
LXH13_05215  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
LXH13_31635  glycerate kinase [KO:K00865] [EC:2.7.1.165]
LXH13_22390  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
LXH13_02875  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
LXH13_14685  2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LXH13_27915  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LXH13_22920  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
LXH13_09315  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
LXH13_20755  HAD-IB family phosphatase [KO:K01079] [EC:3.1.3.3]
LXH13_33555  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
LXH13_33550  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
LXH13_23210  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
LXH13_03530  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
LXH13_30715  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
LXH13_06760  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
LXH13_27670  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
LXH13_11450  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
LXH13_30690  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
LXH13_39230  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
LXH13_27665  gcvH; glycine cleavage system protein GcvH [KO:K02437]
LXH13_31670  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
LXH13_05260  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
LXH13_16755  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
LXH13_28575  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
LXH13_28675  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
LXH13_03535  aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
LXH13_05245  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
LXH13_05225  FAD-dependent oxidoreductase [KO:K00309] [EC:1.5.3.10]
LXH13_05205  sarcosine oxidase subunit delta family protein [KO:K00302] [EC:1.5.3.24 1.5.3.1]
LXH13_05210  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
LXH13_05200  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
LXH13_24300  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
LXH13_20770  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
LXH13_27655  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
LXH13_16030  ilvA; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
LXH13_37160  pyridoxal-phosphate dependent enzyme [KO:K01754] [EC:4.3.1.19]
LXH13_02410  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
LXH13_10725  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
LXH13_10730  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
LXH13_09625  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
LXH13_29220  aminotransferase class III-fold pyridoxal phosphate-dependent enzyme [KO:K00836] [EC:2.6.1.76]
LXH13_09620  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
LXH13_09630  ectoine synthase [KO:K06720] [EC:4.2.1.108]
LXH13_09635  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
LXH13_15500  desA; lysine decarboxylase DesA [KO:K13745] [EC:4.1.1.86]
LXH13_10560  aminotransferase class V-fold PLP-dependent enzyme [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sspn00010  Glycolysis / Gluconeogenesis
sspn00020  Citrate cycle (TCA cycle)
sspn00230  Purine metabolism
sspn00250  Alanine, aspartate and glutamate metabolism
sspn00270  Cysteine and methionine metabolism
sspn00290  Valine, leucine and isoleucine biosynthesis
sspn00300  Lysine biosynthesis
sspn00330  Arginine and proline metabolism
sspn00460  Cyanoamino acid metabolism
sspn00470  D-Amino acid metabolism
sspn00564  Glycerophospholipid metabolism
sspn00600  Sphingolipid metabolism
sspn00620  Pyruvate metabolism
sspn00630  Glyoxylate and dicarboxylate metabolism
sspn00640  Propanoate metabolism
sspn00680  Methane metabolism
sspn00860  Porphyrin metabolism
sspn00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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