KEGG   PATHWAY: stee00260
Entry
stee00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Streptomyces tendae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
stee00260  Glycine, serine and threonine metabolism
stee00260

Module
stee_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:stee00260]
stee_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:stee00260]
stee_M00621  Glycine cleavage system [PATH:stee00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptomyces tendae [GN:stee]
Gene
F3L20_26625  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
F3L20_01285  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
F3L20_06065  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
F3L20_30020  threonine synthase [KO:K01733] [EC:4.2.3.1]
F3L20_06070  threonine synthase [KO:K01733] [EC:4.2.3.1]
F3L20_22595  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
F3L20_04000  glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
F3L20_06580  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
F3L20_30225  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
F3L20_06805  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
F3L20_29730  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
F3L20_08795  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
F3L20_15180  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
F3L20_15175  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
F3L20_10980  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
F3L20_06590  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
F3L20_24450  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
F3L20_06585  gcvH; glycine cleavage system protein GcvH [KO:K02437]
F3L20_14925  FAD-binding oxidoreductase [KO:K00273] [EC:1.4.3.3]
F3L20_13705  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
F3L20_03955  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
F3L20_07455  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
F3L20_07490  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
F3L20_14475  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
F3L20_28655  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
F3L20_31460  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
F3L20_06575  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
F3L20_04550  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
F3L20_21635  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
F3L20_23745  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
F3L20_23750  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
F3L20_08460  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
F3L20_08465  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
F3L20_08455  ectoine synthase [KO:K06720] [EC:4.2.1.108]
F3L20_08450  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
F3L20_27250  desA; lysine decarboxylase DesA [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
stee00010  Glycolysis / Gluconeogenesis
stee00020  Citrate cycle (TCA cycle)
stee00230  Purine metabolism
stee00250  Alanine, aspartate and glutamate metabolism
stee00270  Cysteine and methionine metabolism
stee00290  Valine, leucine and isoleucine biosynthesis
stee00300  Lysine biosynthesis
stee00330  Arginine and proline metabolism
stee00460  Cyanoamino acid metabolism
stee00470  D-Amino acid metabolism
stee00564  Glycerophospholipid metabolism
stee00600  Sphingolipid metabolism
stee00620  Pyruvate metabolism
stee00630  Glyoxylate and dicarboxylate metabolism
stee00640  Propanoate metabolism
stee00680  Methane metabolism
stee00860  Porphyrin metabolism
stee00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system