KEGG   PATHWAY: tfs04371
Entry
tfs04371                    Pathway                                
Name
Apelin signaling pathway - Takifugu flavidus (sansaifugu)
Description
Apelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various tissues and organ systems. They are implicated in different key physiological processes such as angiogenesis, cardiovascular functions, cell proliferation and energy metabolism regulation. On the other hand, this ligand receptor couple is also involved in several pathologies including diabetes, obesity, cardiovascular disease and cancer.
Class
Environmental Information Processing; Signal transduction
Pathway map
tfs04371  Apelin signaling pathway
tfs04371

Other DBs
GO: 0060183
Organism
Takifugu flavidus (sansaifugu) [GN:tfs]
Gene
130529086  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
130538675  adcy1a; LOW QUALITY PROTEIN: adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
130532478  adcy2a; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
130518647  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
130515968  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
130532052  adcy3a; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
130524813  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
130529878  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
130530663  adenylate cyclase type 6-like isoform X1 [KO:K08046] [EC:4.6.1.1]
130521879  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
130523019  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
130516250  si:dkey-206f10.1; LOW QUALITY PROTEIN: adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
130538837  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
130527581  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
130515478  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
130527227  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
130539508  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
130528158  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
130519744  lipeb; LOW QUALITY PROTEIN: hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
130517918  lipea; lipase, hormone-sensitive a [KO:K07188] [EC:3.1.1.79]
130531202  apln; apelin isoform X1 [KO:K05225]
130528009  apela; apelin receptor early endogenous ligand [KO:K25355]
130536613  aplnr2; apelin receptor 2 [KO:K04174]
130517566  apelin receptor B-like [KO:K04174]
130525850  apelin receptor A [KO:K04174]
130519142  gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
130529859  gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
130523857  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
130536358  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
130525027  gnai2b; guanine nucleotide-binding protein G(i) subunit alpha-2b [KO:K04630]
130530190  gnb1a; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
130524226  gnb1b; guanine nucleotide binding protein (G protein), beta polypeptide 1b [KO:K04536]
130537895  gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
130528053  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3-like [KO:K07825]
130533009  gnb3a; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3a [KO:K07825]
130528204  guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
130520163  gnb5b; guanine nucleotide-binding protein subunit beta-5b [KO:K04539]
130535904  gnb5a; guanine nucleotide-binding protein subunit beta-5a [KO:K04539]
130539937  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
130537591  gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
130534002  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
130515513  si:dkey-204f11.64; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
130539078  gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
130512958  gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
130537145  gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
130517372  gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
130527681  si:ch211-286b5.5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
130515592  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
130538636  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347]
130528087  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13-like [KO:K04547]
130515514  gng13b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13b [KO:K04547]
130518160  gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
130539746  gngt2b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2b [KO:K04549]
130516731  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
130525942  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
130513289  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
130534177  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
130522240  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
130516591  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
130516593  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
130524771  itpr1a; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
130524856  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
130536793  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
130530401  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
130534577  ryr1b; ryanodine receptor 1b isoform X1 [KO:K04961]
130538094  ryanodine receptor 1-like isoform X1 [KO:K04961]
130534091  ryanodine receptor 2-like isoform X1 [KO:K04962]
130525700  ryr2a; ryanodine receptor 2 isoform X1 [KO:K04962]
130540053  ryanodine receptor 3-like isoform X1 [KO:K04963]
130516554  ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
130534050  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
130521917  calml4a; calmodulin-like protein 4a [KO:K02183]
130535037  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
130515741  calmodulin-1 [KO:K02183]
130536611  calml4b; calmodulin-like protein 4 [KO:K02183]
130525474  nos1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
130533229  prkcea; LOW QUALITY PROTEIN: protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
130534076  protein kinase C epsilon type-like [KO:K18050] [EC:2.7.11.13]
130517808  Na(+)/H(+) exchanger beta-like isoform X1 [KO:K05742]
130532884  slc9a1a; Na(+)/H(+) exchanger beta isoform X1 [KO:K05742]
130533453  slc8a1b; sodium/calcium exchanger 1b isoform X1 [KO:K05849]
130527416  slc8a1a; sodium/calcium exchanger 1a isoform X1 [KO:K05849]
130539861  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
130534586  slc8a2b; sodium/calcium exchanger 2b [KO:K05849]
130522241  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
130537537  slc8a4a; solute carrier family 8 member 4a [KO:K05849]
130521763  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
130528397  mylk4b; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
130514969  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
130539264  mylk4a; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
130524329  myl2a; myosin regulatory light chain 2a [KO:K10351]
130525264  myl2b; myosin, light chain 2b, regulatory, cardiac, slow isoform X1 [KO:K10351]
130538335  myl13; myosin, light chain 13 isoform X1 [KO:K12749]
130517139  cmlc1; cardiac myosin light chain-1 [KO:K12750]
130536738  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
130514432  zgc:55558; GTPase KRas [KO:K07827]
130536798  kras; GTPase KRas isoform X1 [KO:K07827]
130521458  rras2; ras-related protein R-Ras2 [KO:K07830]
130523374  rras; ras-related protein R-Ras isoform X1 [KO:K07830]
130528816  ras-related protein M-Ras [KO:K07831]
130529511  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
130535835  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
130528688  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
130515150  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
130526022  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
130535301  rps6kb1b; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
130537411  rps6kb1a; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
130526789  ribosomal protein S6 kinase beta-2-like isoform X1 [KO:K04688] [EC:2.7.11.1]
130526667  rps6; 40S ribosomal protein S6 [KO:K02991]
130519295  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
130529987  si:rp71-17i16.5; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
130527606  pik3r5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
130527609  phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
130527459  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
130513171  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
130534218  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
130535619  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
130538213  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
130529749  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
130537398  early growth response protein 1-B-like [KO:K09203]
130531306  egr1; early growth response protein 1 [KO:K09203]
130533362  jag1b; protein jagged-1b [KO:K06052]
130535202  protein jagged-1b isoform X1 [KO:K06052]
130514388  notch3; neurogenic locus notch homolog protein 3 [KO:K20995]
130536034  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
130521036  pde3b; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
130523156  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
130532166  pik3r4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
130522995  becn1; beclin-1 [KO:K08334]
130527544  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
130536462  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B isoform X1 [KO:K10435]
130530806  map1lc3cl; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
130524950  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
130529127  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
130516785  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
130517193  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a [KO:K07199]
130538327  prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
130526063  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b [KO:K07199]
130513696  uncharacterized protein LOC130513696 isoform X1 [KO:K07200]
130534319  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b isoform X1 [KO:K07200]
130522265  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
130524094  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
130539422  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
130522066  ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
130519001  nrf1; nuclear respiratory factor 1 isoform X1 [KO:K11831]
130526309  tfam; transcription factor A, mitochondrial [KO:K11830]
130529328  Krueppel-like factor 2 isoform X1 [KO:K17845]
130538467  klf2b; Krueppel-like factor 2b [KO:K17845]
130514634  sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
130532917  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
130514840  gna13b; guanine nucleotide-binding protein subunit alpha-13b [KO:K04639]
130530704  guanine nucleotide-binding protein subunit alpha-13-like [KO:K04639]
130528791  si:ch73-60h1.1; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
130514645  hdac5; histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
130522216  histone deacetylase 4-like isoform X1 [KO:K11406] [EC:3.5.1.98]
130522627  hdac4; histone deacetylase 4 isoform X1 [KO:K11406] [EC:3.5.1.98]
130535721  mef2aa; myocyte enhancer factor 2aa isoform X1 [KO:K09260]
130528600  mef2b; myocyte-specific enhancer factor 2B [KO:K09261]
130525245  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
130517225  myocyte-specific enhancer factor 2C-like isoform X1 [KO:K04454]
130532121  mef2d; myocyte-specific enhancer factor 2D [KO:K09262]
130518574  myocyte-specific enhancer factor 2D homolog isoform X1 [KO:K09262]
130513567  tgfbr1b; TGF-beta receptor type-1b isoform X1 [KO:K04674] [EC:2.7.11.30]
130525690  mothers against decapentaplegic homolog 2 [KO:K04500]
130517732  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
130517159  smad4a; mothers against decapentaplegic homolog 4a [KO:K04501]
130525278  mothers against decapentaplegic homolog 4-like [KO:K04501]
130518262  smad10a; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
130540373  acta2; actin, aortic smooth muscle isoform X1 [KO:K12313]
130533542  cdh31; B-cadherin isoform X1 [KO:K05689]
130536803  cadherin-1-like [KO:K05689]
130516095  ccn2a; CCN family member 2a [KO:K06827]
130514085  LOW QUALITY PROTEIN: type-1 angiotensin II receptor-like [KO:K04166]
130523039  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
130526361  plat; tissue-type plasminogen activator isoform X1 [KO:K01343] [EC:3.4.21.68]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00290  Fibrin
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
Reference
PMID:26143239
  Authors
Yang P, Maguire JJ, Davenport AP
  Title
Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system.
  Journal
Trends Pharmacol Sci 36:560-7 (2015)
DOI:10.1016/j.tips.2015.06.002
Reference
PMID:22140623
  Authors
Andersen CU, Hilberg O, Mellemkjaer S, Nielsen-Kudsk JE, Simonsen U
  Title
Apelin and pulmonary hypertension.
  Journal
Pulm Circ 1:334-46 (2011)
DOI:10.4103/2045-8932.87299
Reference
PMID:25275559
  Authors
Chapman NA, Dupre DJ, Rainey JK
  Title
The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR.
  Journal
Biochem Cell Biol 92:431-40 (2014)
DOI:10.1139/bcb-2014-0072
Reference
PMID:18272138
  Authors
Japp AG, Newby DE
  Title
The apelin-APJ system in heart failure: pathophysiologic relevance and therapeutic potential.
  Journal
Biochem Pharmacol 75:1882-92 (2008)
DOI:10.1016/j.bcp.2007.12.015
Reference
PMID:25652330
  Authors
Folino A, Montarolo PG, Samaja M, Rastaldo R
  Title
Effects of apelin on the cardiovascular system.
  Journal
Heart Fail Rev 20:505-18 (2015)
DOI:10.1007/s10741-015-9475-x
Reference
PMID:23943882
  Authors
O'Carroll AM, Lolait SJ, Harris LE, Pope GR
  Title
The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis.
  Journal
J Endocrinol 219:R13-35 (2013)
DOI:10.1530/JOE-13-0227
Reference
PMID:23973488
  Authors
Liu QF, Yu HW, You L, Liu MX, Li KY, Tao GZ
  Title
Apelin-13-induced proliferation and migration induced of rat vascular smooth muscle cells is mediated by the upregulation of Egr-1.
  Journal
Biochem Biophys Res Commun 439:235-40 (2013)
DOI:10.1016/j.bbrc.2013.08.051
Reference
PMID:26254105
  Authors
Novakova V, Sandhu GS, Dragomir-Daescu D, Klabusay M
  Title
Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia.
  Journal
Vascul Pharmacol 76:1-10 (2016)
DOI:10.1016/j.vph.2015.08.005
Reference
PMID:21725702
  Authors
Castan-Laurell I, Dray C, Attane C, Duparc T, Knauf C, Valet P
  Title
Apelin, diabetes, and obesity.
  Journal
Endocrine 40:1-9 (2011)
DOI:10.1007/s12020-011-9507-9
Reference
PMID:23924696
  Authors
Li L, Li L, Xie F, Zhang Z, Guo Y, Tang G, Lv D, Lu Q, Chen L, Li J
  Title
Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation.
  Journal
Acta Biochim Biophys Sin (Shanghai) 45:875-81 (2013)
DOI:10.1093/abbs/gmt085
Reference
PMID:24990699
  Authors
Wu D, He L, Chen L
  Title
Apelin/APJ system: a promising therapy target for hypertension.
  Journal
Mol Biol Rep 41:6691-703 (2014)
DOI:10.1007/s11033-014-3552-4
Reference
PMID:20539939
  Authors
Liu C, Su T, Li F, Li L, Qin X, Pan W, Feng F, Chen F, Liao D, Chen L
  Title
PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13.
  Journal
Acta Biochim Biophys Sin (Shanghai) 42:396-402 (2010)
DOI:10.1093/abbs/gmq035
Reference
PMID:26607438
  Authors
Xie F, Liu W, Feng F, Li X, He L, Lv D, Qin X, Li L, Li L, Chen L
  Title
Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy.
  Journal
Acta Biochim Biophys Sin (Shanghai) 47:969-80 (2015)
DOI:10.1093/abbs/gmv111
Reference
PMID:27979574
  Authors
Lu L, Wu D, Li L, Chen L
  Title
Apelin/APJ system: A bifunctional target for cardiac hypertrophy.
  Journal
Int J Cardiol 230:164-170 (2017)
DOI:10.1016/j.ijcard.2016.11.215
Reference
PMID:16182514
  Authors
Carmen GY, Victor SM
  Title
Signalling mechanisms regulating lipolysis.
  Journal
Cell Signal 18:401-8 (2006)
DOI:10.1016/j.cellsig.2005.08.009
Reference
PMID:27650065
  Authors
Hu H, He L, Li L, Chen L
  Title
Apelin/APJ system as a therapeutic target in diabetes and its complications.
  Journal
Mol Genet Metab 119:20-7 (2016)
DOI:10.1016/j.ymgme.2016.07.012
Reference
PMID:25914650
  Authors
Bertrand C, Valet P, Castan-Laurell I
  Title
Apelin and energy metabolism.
  Journal
Front Physiol 6:115 (2015)
DOI:10.3389/fphys.2015.00115
Reference
PMID:26385179
  Authors
Yao F, Lv YC, Zhang M, Xie W, Tan YL, Gong D, Cheng HP, Liu D, Li L, Liu XY, Zheng XL, Tang CK
  Title
Apelin-13 impedes foam cell formation by activating Class III PI3K/Beclin-1-mediated autophagic pathway.
  Journal
Biochem Biophys Res Commun 466:637-43 (2015)
DOI:10.1016/j.bbrc.2015.09.045
Reference
PMID:22842084
  Authors
Than A, Cheng Y, Foh LC, Leow MK, Lim SC, Chuah YJ, Kang Y, Chen P
  Title
Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways.
  Journal
Mol Cell Endocrinol 362:227-41 (2012)
DOI:10.1016/j.mce.2012.07.002
Reference
PMID:24055369
  Authors
Yu XH, Tang ZB, Liu LJ, Qian H, Tang SL, Zhang DW, Tian GP, Tang CK
  Title
Apelin and its receptor APJ in cardiovascular diseases.
  Journal
Clin Chim Acta 428:1-8 (2014)
DOI:10.1016/j.cca.2013.09.001
Reference
PMID:25931124
  Authors
Than A, He HL, Chua SH, Xu D, Sun L, Leow MK, Chen P
  Title
Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes.
  Journal
J Biol Chem 290:14679-91 (2015)
DOI:10.1074/jbc.M115.643817
Reference
PMID:25139773
  Authors
Fu J, Li Z, Zhang H, Mao Y, Wang A, Wang X, Zou Z, Zhang X
  Title
Molecular pathways regulating the formation of brown-like adipocytes in white adipose tissue.
  Journal
Diabetes Metab Res Rev 31:433-52 (2015)
DOI:10.1002/dmrr.2600
Reference
PMID:21464822
  Authors
Aharoni-Simon M, Hann-Obercyger M, Pen S, Madar Z, Tirosh O
  Title
Fatty liver is associated with impaired activity of PPARgamma-coactivator 1alpha (PGC1alpha) and mitochondrial biogenesis in mice.
  Journal
Lab Invest 91:1018-28 (2011)
DOI:10.1038/labinvest.2011.55
Reference
PMID:22995518
  Authors
McLean DL, Kim J, Kang Y, Shi H, Atkins GB, Jain MK, Chun HJ
  Title
Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report.
  Journal
Arterioscler Thromb Vasc Biol 32:2640-3 (2012)
DOI:10.1161/ATVBAHA.112.300317
Reference
PMID:22028387
  Authors
Pchejetski D, Foussal C, Alfarano C, Lairez O, Calise D, Guilbeau-Frugier C, Schaak S, Seguelas MH, Wanecq E, Valet P, Parini A, Kunduzova O
  Title
Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1.
  Journal
Eur Heart J 33:2360-9 (2012)
DOI:10.1093/eurheartj/ehr389
Reference
PMID:26944568
  Authors
Huang S, Chen L, Lu L, Li L
  Title
The apelin-APJ axis: A novel potential therapeutic target for organ fibrosis.
  Journal
Clin Chim Acta 456:81-8 (2016)
DOI:10.1016/j.cca.2016.02.025
Reference
PMID:19093215
  Authors
Liu G, Han J, Profirovic J, Strekalova E, Voyno-Yasenetskaya TA
  Title
Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis.
  Journal
Angiogenesis 12:1-15 (2009)
DOI:10.1007/s10456-008-9123-3
Reference
PMID:23603510
  Authors
Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ
  Title
Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.
  Journal
Circ Res 113:22-31 (2013)
DOI:10.1161/CIRCRESAHA.113.301324
Reference
PMID:25164121
  Authors
Wang LY, Diao ZL, Zhang DL, Zheng JF, Zhang QD, Ding JX, Liu WH
  Title
The regulatory peptide apelin: a novel inhibitor of renal interstitial fibrosis.
  Journal
Amino Acids 46:2693-704 (2014)
DOI:10.1007/s00726-014-1826-8
Reference
PMID:26756969
  Authors
Zhou Y, Deng L, Zhao D, Chen L, Yao Z, Guo X, Liu X, Lv L, Leng B, Xu W, Qiao G, Shan H
  Title
MicroRNA-503 promotes angiotensin II-induced cardiac fibrosis by targeting Apelin-13.
  Journal
J Cell Mol Med 20:495-505 (2016)
DOI:10.1111/jcmm.12754
Reference
PMID:27825851
  Authors
Zhong JC, Zhang ZZ, Wang W, McKinnie SM, Vederas JC, Oudit GY
  Title
Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases.
  Journal
Biochim Biophys Acta 1863:1942-1950 (2017)
DOI:10.1016/j.bbadis.2016.11.007
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pathway
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