KEGG   PATHWAY: tge03040
Entry
tge03040                    Pathway                                
Name
Spliceosome - Theropithecus gelada (gelada)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
tge03040  Spliceosome
tge03040

Other DBs
GO: 0005681
Organism
Theropithecus gelada (gelada) [GN:tge]
Gene
112614760  U1 spliceosomal RNA [KO:K14276]
112614721  U1 spliceosomal RNA [KO:K14276]
112633916  U1 spliceosomal RNA [KO:K14276]
112614755  U1 spliceosomal RNA [KO:K14276]
112614774  U1 spliceosomal RNA [KO:K14276]
112611776  U1 spliceosomal RNA [KO:K14276]
112614750  U1 spliceosomal RNA [KO:K14276]
112624030  U1 spliceosomal RNA [KO:K14276]
112614767  U1 spliceosomal RNA [KO:K14276]
112627308  U1 spliceosomal RNA [KO:K14276]
112630908  U1 spliceosomal RNA [KO:K14276]
112619978  U1 spliceosomal RNA [KO:K14276]
112635737  U1 spliceosomal RNA [KO:K14276]
112624033  U1 spliceosomal RNA [KO:K14276]
112625557  U1 spliceosomal RNA [KO:K14276]
112614799  U1 spliceosomal RNA [KO:K14276]
112614844  U1 spliceosomal RNA [KO:K14276]
112614885  U1 spliceosomal RNA [KO:K14276]
112630907  U1 spliceosomal RNA [KO:K14276]
112614715  U1 spliceosomal RNA [KO:K14276]
112635723  U1 spliceosomal RNA [KO:K14276]
112619982  U1 spliceosomal RNA [KO:K14276]
112616779  U1 spliceosomal RNA [KO:K14276]
112610455  U1 spliceosomal RNA [KO:K14276]
112614783  U1 spliceosomal RNA [KO:K14276]
112617674  U1 spliceosomal RNA [KO:K14276]
112611206  U1 spliceosomal RNA [KO:K14276]
112627309  U1 spliceosomal RNA [KO:K14276]
112607527  U1 spliceosomal RNA [KO:K14276]
112627312  U2 spliceosomal RNA [KO:K14277]
112616831  U2 spliceosomal RNA [KO:K14277]
112633921  U2 spliceosomal RNA [KO:K14277]
112627316  U2 spliceosomal RNA [KO:K14277]
112608791  U2 spliceosomal RNA [KO:K14277]
112617807  U2 spliceosomal RNA [KO:K14277]
112614896  U2 spliceosomal RNA [KO:K14277]
112624038  U2 spliceosomal RNA [KO:K14277]
112633923  U2 spliceosomal RNA [KO:K14277]
112625648  U2 spliceosomal RNA [KO:K14277]
112610512  U2 spliceosomal RNA [KO:K14277]
112607531  U2 spliceosomal RNA [KO:K14277]
112633922  U2 spliceosomal RNA [KO:K14277]
112635744  U4 spliceosomal RNA [KO:K14278]
112610531  U4 spliceosomal RNA [KO:K14278]
112635746  U4 spliceosomal RNA [KO:K14278]
112635745  U4 spliceosomal RNA [KO:K14278]
112620005  U4 spliceosomal RNA [KO:K14278]
112605519  U4 spliceosomal RNA [KO:K14278]
112630926  U4 spliceosomal RNA [KO:K14278]
112614913  U4 spliceosomal RNA [KO:K14278]
112608828  U4 spliceosomal RNA [KO:K14278]
112611219  U4 spliceosomal RNA [KO:K14278]
112622017  U4 spliceosomal RNA [KO:K14278]
112607542  U4 spliceosomal RNA [KO:K14278]
112605518  U4 spliceosomal RNA [KO:K14278]
112615069  U4 spliceosomal RNA [KO:K14278]
112616803  U4 spliceosomal RNA [KO:K14278]
112629643  U4 spliceosomal RNA [KO:K14278]
112622016  U4 spliceosomal RNA [KO:K14278]
112635748  U4 spliceosomal RNA [KO:K14278]
112629641  U4 spliceosomal RNA [KO:K14278]
112627332  U4 spliceosomal RNA [KO:K14278]
112624054  U4 spliceosomal RNA [KO:K14278]
112605517  U4 spliceosomal RNA [KO:K14278]
112615075  U4 spliceosomal RNA [KO:K14278]
112619794  U4 spliceosomal RNA [KO:K14278]
112615093  U5 spliceosomal RNA [KO:K14279]
112627333  U5 spliceosomal RNA [KO:K14279]
112628218  U5 spliceosomal RNA [KO:K14279]
112628219  U5 spliceosomal RNA [KO:K14279]
112616808  U5 spliceosomal RNA [KO:K14279]
112635758  U6 spliceosomal RNA [KO:K14280]
112608853  U6 spliceosomal RNA [KO:K14280]
112629645  U6 spliceosomal RNA [KO:K14280]
112623876  U6 spliceosomal RNA [KO:K14280]
112621851  U6 spliceosomal RNA [KO:K14280]
112616814  U6 spliceosomal RNA [KO:K14280]
112627336  U6 spliceosomal RNA [KO:K14280]
112605523  U6 spliceosomal RNA [KO:K14280]
112614920  U6 spliceosomal RNA [KO:K14280]
112633839  U6 spliceosomal RNA [KO:K14280]
112615511  U6 spliceosomal RNA [KO:K14280]
112625568  U6 spliceosomal RNA [KO:K14280]
112615527  U6 spliceosomal RNA [KO:K14280]
112629526  U6 spliceosomal RNA [KO:K14280]
112633940  U6 spliceosomal RNA [KO:K14280]
112629648  U6 spliceosomal RNA [KO:K14280]
112616668  U6 spliceosomal RNA [KO:K14280]
112610424  U6 spliceosomal RNA [KO:K14280]
112617669  U6 spliceosomal RNA [KO:K14280]
112625539  U6 spliceosomal RNA [KO:K14280]
112616656  U6 spliceosomal RNA [KO:K14280]
112635644  U6 spliceosomal RNA [KO:K14280]
112611241  U6 spliceosomal RNA [KO:K14280]
112628240  U6 spliceosomal RNA [KO:K14280]
112625582  U6 spliceosomal RNA [KO:K14280]
112632332  U6 spliceosomal RNA [KO:K14280]
112616812  U6 spliceosomal RNA [KO:K14280]
112611793  U6 spliceosomal RNA [KO:K14280]
112615159  U6 spliceosomal RNA [KO:K14280]
112607551  U6 spliceosomal RNA [KO:K14280]
112628222  U6 spliceosomal RNA [KO:K14280]
112611806  U6 spliceosomal RNA [KO:K14280]
112627337  U6 spliceosomal RNA [KO:K14280]
112613635  U6 spliceosomal RNA [KO:K14280]
112616643  U6 spliceosomal RNA [KO:K14280]
112635604  U6 spliceosomal RNA [KO:K14280]
112630938  U6 spliceosomal RNA [KO:K14280]
112608835  U6 spliceosomal RNA [KO:K14280]
112619801  U6 spliceosomal RNA [KO:K14280]
112623891  U6 spliceosomal RNA [KO:K14280]
112605528  U6 spliceosomal RNA [KO:K14280]
112619811  U6 spliceosomal RNA [KO:K14280]
112615182  U6 spliceosomal RNA [KO:K14280]
112607554  U6 spliceosomal RNA [KO:K14280]
112619804  U6 spliceosomal RNA [KO:K14280]
112632333  U6 spliceosomal RNA [KO:K14280]
112635760  U6 spliceosomal RNA [KO:K14280]
112635761  U6 spliceosomal RNA [KO:K14280]
112632337  U6 spliceosomal RNA [KO:K14280]
112636875  U6 spliceosomal RNA [KO:K14280]
112636872  U6 spliceosomal RNA [KO:K14280]
112635759  U6 spliceosomal RNA [KO:K14280]
112626316  DDX46; probable ATP-dependent RNA helicase DDX46 isoform X1 [KO:K12811] [EC:5.6.2.7]
112623648  DDX39B; spliceosome RNA helicase DDX39B isoform X1 [KO:K12812] [EC:5.6.2.7]
112622359  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1 [KO:K12813] [EC:5.6.2.6]
112623029  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1 [KO:K12813] [EC:5.6.2.6]
112614424  DHX38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
112622342  CDC40; pre-mRNA-processing factor 17 [KO:K12816]
112631194  PRPF18; pre-mRNA-splicing factor 18 [KO:K12817]
112609069  DHX8; ATP-dependent RNA helicase DHX8 isoform X1 [KO:K12818] [EC:5.6.2.6]
112626350  SLU7; pre-mRNA-splicing factor SLU7 [KO:K12819]
112624449  DHX15; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
112633574  SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 [KO:K11086]
112611461  SNRPD1; small nuclear ribonucleoprotein Sm D1 isoform X1 [KO:K11087]
112612580  SNRPD2; small nuclear ribonucleoprotein Sm D2 isoform X1 [KO:K11096]
112633759  SNRPD3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
112618833  small nuclear ribonucleoprotein E [KO:K11097]
112627789  SNRPE; small nuclear ribonucleoprotein E isoform X1 [KO:K11097]
112634636  SNRPF; small nuclear ribonucleoprotein F [KO:K11098]
112634803  small nuclear ribonucleoprotein F-like [KO:K11098]
112607225  putative small nuclear ribonucleoprotein G-like protein 15 [KO:K11099]
112607957  small nuclear ribonucleoprotein G [KO:K11099]
112605331  SNRPG; small nuclear ribonucleoprotein G isoform X1 [KO:K11099]
112613422  SNRNP70; U1 small nuclear ribonucleoprotein 70 kDa isoform X1 [KO:K11093]
112612419  SNRPA; U1 small nuclear ribonucleoprotein A isoform X1 [KO:K11091]
112622941  SNRPC; U1 small nuclear ribonucleoprotein C [KO:K11095]
112635956  PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821]
112634747  PRPF40B; pre-mRNA-processing factor 40 homolog B isoform X1 [KO:K12821]
112628470  RBM25; RNA-binding protein 25 [KO:K12822]
112609675  DDX5; probable ATP-dependent RNA helicase DDX5 isoform X1 [KO:K12823] [EC:5.6.2.7]
112626172  TCERG1; transcription elongation regulator 1 isoform X1 [KO:K12824]
112613693  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
112628899  SNRPA1; U2 small nuclear ribonucleoprotein A' isoform X1 [KO:K11092]
112633230  SNRPB2; U2 small nuclear ribonucleoprotein B'' [KO:K11094]
112632567  SF3A1; splicing factor 3A subunit 1 [KO:K12825]
112612266  SF3A2; splicing factor 3A subunit 2 [KO:K12826]
112623404  SF3A3; splicing factor 3A subunit 3 isoform X1 [KO:K12827]
112635936  SF3B1; splicing factor 3B subunit 1 isoform X1 [KO:K12828]
112605734  SF3B2; splicing factor 3B subunit 2 isoform X1 [KO:K12829]
112613765  SF3B3; splicing factor 3B subunit 3 [KO:K12830]
112633070  SF3B4; splicing factor 3B subunit 4 [KO:K12831]
112622890  SF3B5; splicing factor 3B subunit 5 [KO:K12832]
112604628  SF3B6; splicing factor 3B subunit 6 isoform X1 [KO:K12833]
112632982  PHF5A; PHD finger-like domain-containing protein 5A isoform X1 [KO:K12834]
112608886  DDX42; ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
112620866  splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836]
112613463  U2AF1L4; splicing factor U2AF 26 kDa subunit isoform X1 [KO:K12836]
112621519  splicing factor U2AF 26 kDa subunit isoform X1 [KO:K12836]
112612634  U2AF2; splicing factor U2AF 65 kDa subunit isoform X1 [KO:K12837]
112630024  PUF60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838]
112631389  SMNDC1; survival of motor neuron-related-splicing factor 30 [KO:K12839]
112631588  RBM17; splicing factor 45 isoform X1 [KO:K12840]
112612086  CHERP; calcium homeostasis endoplasmic reticulum protein [KO:K12841]
112618445  U2SURP; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
112620471  retinitis pigmentosa 9 protein [KO:K19604]
112617522  LSM2; U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
112618360  LSM3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
112612407  LSM4; U6 snRNA-associated Sm-like protein LSm4 isoform X1 [KO:K12623]
112620473  LSM5; U6 snRNA-associated Sm-like protein LSm5 isoform X1 [KO:K12624]
112624626  LSM6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
112612270  LSM7; U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
112620783  LSM8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
112630912  PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
112608476  PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 isoform X1 [KO:K12662]
112622823  PPIH; peptidyl-prolyl cis-trans isomerase H isoform X1 [KO:K09567] [EC:5.2.1.8]
112613074  PRPF31; U4/U6 small nuclear ribonucleoprotein Prp31 isoform X1 [KO:K12844]
112633412  SNU13; NHP2-like protein 1 isoform X1 [KO:K12845]
112604594  SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein isoform X1 [KO:K12846]
112605103  USP39; U4/U6.U5 tri-snRNP-associated protein 2 isoform X1 [KO:K12847]
112617001  U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
112617342  U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
112627084  ZMAT2; zinc finger matrin-type protein 2 [KO:K12848]
112624862  PRPF38A; pre-mRNA-splicing factor 38A [KO:K12849]
112604658  PRPF38B; pre-mRNA-splicing factor 38B [KO:K12850]
112610363  EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component isoform X1 [KO:K12852]
112636949  SNRNP200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
112632719  PRPF6; pre-mRNA-processing factor 6 isoform X1 [KO:K12855]
112609043  PRPF8; pre-mRNA-processing-splicing factor 8 [KO:K12856]
112620710  SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein isoform X1 [KO:K12857]
112634096  DDX23; probable ATP-dependent RNA helicase DDX23 isoform X1 [KO:K12858] [EC:5.6.2.7]
112611496  TXNL4A; thioredoxin-like protein 4A isoform X1 [KO:K12859]
112607301  PRPF19; pre-mRNA-processing factor 19 isoform X1 [KO:K10599] [EC:2.3.2.27]
112622762  CDC5L; cell division cycle 5-like protein [KO:K12860]
112608894  BCAS2; pre-mRNA-splicing factor SPF27 isoform X1 [KO:K12861]
112624514  PLRG1; pleiotropic regulator 1 isoform X1 [KO:K12862]
112606733  CWC15; spliceosome-associated protein CWC15 homolog [KO:K12863]
112632857  CTNNBL1; beta-catenin-like protein 1 [KO:K12864]
112636485  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
112608124  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
112623761  HSPA1B; heat shock 70 kDa protein 1B isoform X1 [KO:K03283]
112623762  heat shock 70 kDa protein 1-like [KO:K03283]
112609472  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
112605795  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
112615440  PQBP1; polyglutamine-binding protein 1 isoform X1 [KO:K12865]
112634660  WBP11; WW domain-binding protein 11 [KO:K12866]
112628628  SNW1; SNW domain-containing protein 1 isoform X1 [KO:K06063]
112613420  XAB2; pre-mRNA-splicing factor SYF1 [KO:K12867]
112606052  SYF2; pre-mRNA-splicing factor SYF2 isoform X1 [KO:K12868]
112633039  CRNKL1; crooked neck-like protein 1 [KO:K12869]
112618500  ISY1; pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
112623451  PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 isoform X1 [KO:K12733] [EC:5.2.1.8]
112629040  PPIE; peptidyl-prolyl cis-trans isomerase E isoform X1 [KO:K09564] [EC:5.2.1.8]
112618826  CCDC12; coiled-coil domain-containing protein 12 isoform X1 [KO:K12871]
112626166  RBM22; pre-mRNA-splicing factor RBM22 [KO:K12872]
112621205  BUD31; protein BUD31 homolog [KO:K12873]
112627790  AQR; RNA helicase aquarius [KO:K12874]
112628264  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
112609311  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
112618669  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
112629254  protein mago nashi homolog 2-like [KO:K12877]
112619331  MAGOH; protein mago nashi homolog isoform X1 [KO:K12877]
112634580  MAGOHB; protein mago nashi homolog 2 isoform X1 [KO:K12877]
112611302  THOC1; THO complex subunit 1 [KO:K12878]
112615724  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
112626057  THOC3; THO complex subunit 3 isoform X1 [KO:K12880]
112609424  ALYREF; THO complex subunit 4 [KO:K12881]
112607596  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
112616441  NCBP2L; nuclear cap-binding protein subunit 2-like [KO:K12883]
112618141  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
112606582  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
112607668  heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
112629418  heterogeneous nuclear ribonucleoprotein A1-like isoform X1 [KO:K12741]
112636619  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
112623143  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
112623367  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
112616054  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
112625264  heterogeneous nuclear ribonucleoprotein A1-like isoform X1 [KO:K12741]
112610809  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
112610857  HNRNPA1L2; LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like 2 [KO:K12741]
112633969  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
112619187  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
112634477  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
112605575  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
112618306  heterogeneous nuclear ribonucleoprotein A3-like isoform X1 [KO:K12741]
112629010  HNRNPC; heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [KO:K12884]
112604874  HNRNPCL1; heterogeneous nuclear ribonucleoprotein C-like 1 [KO:K12884]
112615040  RBMX; RNA-binding motif protein, X chromosome isoform X1 [KO:K12885]
112618202  RNA-binding motif protein, X chromosome-like isoform X1 [KO:K12885]
112608494  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
112612275  HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887]
112631794  HNRNPU; heterogeneous nuclear ribonucleoprotein U isoform X1 [KO:K12888]
112604553  PCBP1; poly(rC)-binding protein 1 isoform X1 [KO:K12889]
112608943  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
112606576  serine/arginine-rich splicing factor 8-like isoform X1 [KO:K12891]
112606748  SRSF8; serine/arginine-rich splicing factor 8 isoform X1 [KO:K12891]
112610349  SRSF2; serine/arginine-rich splicing factor 2 isoform X1 [KO:K12891]
112623310  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
112629273  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
112617438  serine/arginine-rich splicing factor 4 [KO:K12893]
112632811  SRSF6; serine/arginine-rich splicing factor 6 isoform X1 [KO:K12893]
112610706  serine/arginine-rich splicing factor 4-like [KO:K12893]
112636915  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
112635523  SRSF9; serine/arginine-rich splicing factor 9 isoform X1 [KO:K21123]
112620727  TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897]
112618130  TRA2B; LOW QUALITY PROTEIN: transformer-2 protein homolog beta [KO:K12897]
112622913  SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900]
Reference
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

DBGET integrated database retrieval system