Entry
Name
Spliceosome - Theropithecus gelada (gelada)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Theropithecus gelada (gelada) [GN:
tge ]
Gene
112633574 SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 [KO:K11086 ]
112611461 SNRPD1; small nuclear ribonucleoprotein Sm D1 isoform X1 [KO:K11087 ]
112612580 SNRPD2; small nuclear ribonucleoprotein Sm D2 isoform X1 [KO:K11096 ]
112607225 putative small nuclear ribonucleoprotein G-like protein 15 [KO:K11099 ]
112613422 SNRNP70; U1 small nuclear ribonucleoprotein 70 kDa isoform X1 [KO:K11093 ]
112612419 SNRPA; U1 small nuclear ribonucleoprotein A isoform X1 [KO:K11091 ]
112635956 PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821 ]
112634747 PRPF40B; pre-mRNA-processing factor 40 homolog B isoform X1 [KO:K12821 ]
112626172 TCERG1; transcription elongation regulator 1 isoform X1 [KO:K12824 ]
112628899 SNRPA1; U2 small nuclear ribonucleoprotein A' isoform X1 [KO:K11092 ]
112632982 PHF5A; PHD finger-like domain-containing protein 5A isoform X1 [KO:K12834 ]
112613463 U2AF1L4; splicing factor U2AF 26 kDa subunit isoform X1 [KO:K12836 ]
112612634 U2AF2; splicing factor U2AF 65 kDa subunit isoform X1 [KO:K12837 ]
112630024 PUF60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838 ]
112631389 SMNDC1; survival of motor neuron-related-splicing factor 30 [KO:K12839 ]
112612086 CHERP; calcium homeostasis endoplasmic reticulum protein [KO:K12841 ]
112618445 U2SURP; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842 ]
112612407 LSM4; U6 snRNA-associated Sm-like protein LSm4 isoform X1 [KO:K12623 ]
112620473 LSM5; U6 snRNA-associated Sm-like protein LSm5 isoform X1 [KO:K12624 ]
112630912 PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843 ]
112608476 PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 isoform X1 [KO:K12662 ]
112613074 PRPF31; U4/U6 small nuclear ribonucleoprotein Prp31 isoform X1 [KO:K12844 ]
112604594 SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein isoform X1 [KO:K12846 ]
112605103 USP39; U4/U6.U5 tri-snRNP-associated protein 2 isoform X1 [KO:K12847 ]
112610363 EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component isoform X1 [KO:K12852 ]
112620710 SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein isoform X1 [KO:K12857 ]
112609472 HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283 ]
112618826 CCDC12; coiled-coil domain-containing protein 12 isoform X1 [KO:K12871 ]
112628264 ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875 ]
112607596 NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882 ]
112618141 NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883 ]
112607668 heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741 ]
112629418 heterogeneous nuclear ribonucleoprotein A1-like isoform X1 [KO:K12741 ]
112636619 HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741 ]
112625264 heterogeneous nuclear ribonucleoprotein A1-like isoform X1 [KO:K12741 ]
112610857 HNRNPA1L2; LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like 2 [KO:K12741 ]
112633969 HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741 ]
112618306 heterogeneous nuclear ribonucleoprotein A3-like isoform X1 [KO:K12741 ]
112629010 HNRNPC; heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [KO:K12884 ]
112604874 HNRNPCL1; heterogeneous nuclear ribonucleoprotein C-like 1 [KO:K12884 ]
112615040 RBMX; RNA-binding motif protein, X chromosome isoform X1 [KO:K12885 ]
112618202 RNA-binding motif protein, X chromosome-like isoform X1 [KO:K12885 ]
112608494 HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886 ]
112612275 HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887 ]
112631794 HNRNPU; heterogeneous nuclear ribonucleoprotein U isoform X1 [KO:K12888 ]
112606576 serine/arginine-rich splicing factor 8-like isoform X1 [KO:K12891 ]
112606748 SRSF8; serine/arginine-rich splicing factor 8 isoform X1 [KO:K12891 ]
112610349 SRSF2; serine/arginine-rich splicing factor 2 isoform X1 [KO:K12891 ]
112629273 SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893 ]
112632811 SRSF6; serine/arginine-rich splicing factor 6 isoform X1 [KO:K12893 ]
112636915 SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896 ]
112635523 SRSF9; serine/arginine-rich splicing factor 9 isoform X1 [KO:K21123 ]
112620727 TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897 ]
112618130 TRA2B; LOW QUALITY PROTEIN: transformer-2 protein homolog beta [KO:K12897 ]
112622913 SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900 ]
Reference
Authors
Wahl MC, Will CL, Luhrmann R
Title
The spliceosome: design principles of a dynamic RNP machine.
Journal
Reference
Authors
Morris DP, Greenleaf AL
Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
Journal
Reference
Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
Journal
Reference
Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
Title
Spliceosome structure: piece by piece.
Journal
KO pathway
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