KEGG PATHWAY: tgu00260

PATHWAY: tgu00260

Entry

tgu00260                    Pathway

Name

Glycine, serine and threonine metabolism - Taeniopygia guttata (zebra finch)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

tgu00260

Glycine, serine and threonine metabolism

Module

tgu_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:tgu00260]

tgu_M00047

Creatine pathway [PATH:tgu00260]

tgu_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:tgu00260]

tgu_M00555

Betaine biosynthesis, choline => betaine [PATH:tgu00260]

tgu_M00621

Glycine cleavage system [PATH:tgu00260]

tgu_M00974

Betaine metabolism, animals, betaine => glycine [PATH:tgu00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Taeniopygia guttata (zebra finch) [GN:tgu]

Gene

115497647

LOW QUALITY PROTEIN: probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]

100228021

SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]

100228756

SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]

100232024

AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

100229871

GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

101233932

PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]

100221163

BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]

115496299

PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

100217791

PSAT1; phosphoserine aminotransferase isoform X2 [KO:K00831] [EC:2.6.1.52]

100225069

PSPH; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]

100230135

GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]

101234062

L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]

100231674

ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]

100223232

amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]

100221249

amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]

101234248

membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]

101233846

membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]

105758909

membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]

100231195

GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]

100223031

AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]

100230199

DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]

100226063

GCSH; glycine cleavage system H protein, mitochondrial isoform X1 [KO:K02437]

100227661

DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]

100230972

prolactin receptor isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]

100224553

GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]

100218458

GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]

100224032

CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]

100223716

ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

100221623

betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

100231246

DMGDH; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]

101233715

PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

100221431

SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]

100231507

GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

100225076

cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]

100222166

cystathionine beta-synthase-like protein [KO:K01697] [EC:4.2.1.22]

115496138

CTH; cystathionine gamma-lyase isoform X2 [KO:K01758] [EC:4.4.1.1]

100227087

L-threonine ammonia-lyase-like isoform X5 [KO:K01754] [EC:4.3.1.19]

115497373

SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

100219482

SRR; serine racemase isoform X2 [KO:K12235] [EC:5.1.1.18]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721