KEGG PATHWAY: tmu00260

PATHWAY: tmu00260

Entry

tmu00260                    Pathway

Name

Glycine, serine and threonine metabolism - Trichechus manatus latirostris (Florida manatee)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

tmu00260

Glycine, serine and threonine metabolism

Module

tmu_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:tmu00260]

tmu_M00047

Creatine pathway [PATH:tmu00260]

tmu_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:tmu00260]

tmu_M00555

Betaine biosynthesis, choline => betaine [PATH:tmu00260]

tmu_M00621

Glycine cleavage system [PATH:tmu00260]

tmu_M00974

Betaine metabolism, animals, betaine => glycine [PATH:tmu00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Trichechus manatus latirostris (Florida manatee) [GN:tmu]

Gene

101347411

probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]

101341921

serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]

101340384

serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]

101340497

serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

101344280

glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

101352487

glycerate kinase isoform X2 [KO:K11529] [EC:2.7.1.165]

101353017

phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]

101345827

phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]

101360256

bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]

101357813

D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

101346511

phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

105756530

LOW QUALITY PROTEIN: phosphoserine aminotransferase-like [KO:K00831] [EC:2.6.1.52]

101348368

phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

101359271

2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]

101361374

LOW QUALITY PROTEIN: L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]

101351282

5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]

101342212

5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]

101360324

amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]

101351235

amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]

101358556

membrane primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]

101358986

membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]

101351829

LOW QUALITY PROTEIN: retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]

101357455

glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]

101357508

aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]

101351699

dihydrolipoyl dehydrogenase, mitochondrial isoform X1 [KO:K00382] [EC:1.8.1.4]

101345456

glycine cleavage system H protein, mitochondrial [KO:K02437]

101352892

D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]

101347029

alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]

101346149

glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]

101353747

guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]

101357842

choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]

101361542

alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

101354749

betaine--homocysteine S-methyltransferase 1 isoform X1 [KO:K00544] [EC:2.1.1.5]

101355257

dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]

101354539

peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

101344177

sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]

101355018

glycine N-methyltransferase isoform X2 [KO:K00552] [EC:2.1.1.20]

101347618

LOW QUALITY PROTEIN: cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]

101354471

cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

101343009

serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

101345461

L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]

101360579

serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721