KEGG   PATHWAY: tmu04714
Entry
tmu04714                    Pathway                                
Name
Thermogenesis - Trichechus manatus latirostris (Florida manatee)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
Pathway map
tmu04714  Thermogenesis
tmu04714

Other DBs
GO: 1990845
Organism
Trichechus manatus latirostris (Florida manatee) [GN:tmu]
Gene
101347777  beta-3 adrenergic receptor [KO:K04143]
101361837  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas [KO:K04632]
101348142  neuroendocrine secretory protein 55 [KO:K04632]
101354868  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101360334  adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101349290  adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101350438  adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
101346041  adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
101349243  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
101341715  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101350704  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101344705  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101355469  adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
101342638  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101348995  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101356881  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101355964  cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
101349137  cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
101344337  cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
101344076  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101352607  cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101345798  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
101347783  PR domain zinc finger protein 16 [KO:K22410] [EC:2.1.1.367]
101355646  zinc finger protein 516 [KO:K22411]
101347919  lysine-specific histone demethylase 1A [KO:K11450] [EC:1.14.99.66]
101342872  LOW QUALITY PROTEIN: mitochondrial brown fat uncoupling protein 1 [KO:K08769]
101359931  lysine-specific demethylase 3A isoform X1 [KO:K15601] [EC:1.14.11.65]
101359737  lysine-specific demethylase 3B isoform X2 [KO:K15601] [EC:1.14.11.65]
101351066  transcription activator BRG1 isoform X2 [KO:K11647] [EC:5.6.2.-]
101354166  probable global transcription activator SNF2L2 isoform X1 [KO:K11647] [EC:5.6.2.-]
101347788  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
101345666  SWI/SNF complex subunit SMARCC1 isoform X6 [KO:K11649]
101352375  SWI/SNF complex subunit SMARCC2 isoform X4 [KO:K11649]
101359413  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 isoform X4 [KO:K11650]
101359955  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 [KO:K11650]
101353479  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
101343007  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 [KO:K11651]
101358156  actin, cytoplasmic 1 [KO:K05692]
101344372  actin, cytoplasmic 2 [KO:K05692]
101347859  actin-like protein 6A isoform X1 [KO:K11340]
101344907  actin-like protein 6B isoform X1 [KO:K11652]
101344298  AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653]
101344508  AT-rich interactive domain-containing protein 1B isoform X1 [KO:K11653]
101344834  zinc finger protein DPF3 [KO:K22198]
101354128  zinc finger protein neuro-d4 isoform X2 [KO:K22198]
101356506  peroxisome proliferator-activated receptor gamma isoform X2 [KO:K08530]
101346612  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
101355711  dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101352466  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101347350  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101361614  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101361872  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101340445  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
101359884  cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
101340638  NAD-dependent protein deacetylase sirtuin-6 isoform X1 [KO:K11416] [EC:2.3.1.286]
101356236  fibroblast growth factor 21 [KO:K22429]
101349504  perilipin-1 [KO:K08768]
101361564  hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
101353614  patatin-like phospholipase domain-containing protein 2 [KO:K16816] [EC:3.1.1.3]
101348554  monoglyceride lipase isoform X2 [KO:K01054] [EC:3.1.1.23]
101346784  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
101360368  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
101356476  5'-AMP-activated protein kinase subunit beta-2 isoform X2 [KO:K07199]
101361359  5'-AMP-activated protein kinase subunit beta-1 isoform X2 [KO:K07199]
101341480  5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
101352672  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
101349182  5'-AMP-activated protein kinase subunit gamma-2 isoform X2 [KO:K07200]
101340703  glucagon [KO:K05259]
101361843  bone morphogenetic protein 8B [KO:K16622]
101340527  bone morphogenetic protein 8B [KO:K16622]
101348138  cannabinoid receptor 1 isoform X1 [KO:K04277]
101359460  natriuretic peptides A [KO:K12334]
101359197  natriuretic peptides B [KO:K12335]
101346019  atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
101346076  cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
101357068  beta-klotho isoform X1 [KO:K22404]
101342270  fibroblast growth factor receptor 1 isoform X2 [KO:K04362] [EC:2.7.10.1]
101350670  fibroblast growth factor receptor substrate 2 isoform X1 [KO:K12461]
101359012  growth factor receptor-bound protein 2 [KO:K04364]
101359592  son of sevenless homolog 1 isoform X1 [KO:K03099]
101347392  son of sevenless homolog 2 isoform X1 [KO:K03099]
101342804  GTPase HRas isoform X2 [KO:K02833]
101347525  GTPase KRas isoform X3 [KO:K07827]
101344230  GTPase NRas isoform X1 [KO:K07828]
101340600  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
101344716  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
101343514  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
101352388  ribosomal protein S6 kinase alpha-3 isoform X5 [KO:K04373] [EC:2.7.11.1]
101347417  hamartin isoform X1 [KO:K07206]
101358131  tuberin [KO:K07207]
101360739  GTP-binding protein Rheb isoform X2 [KO:K07208]
101343081  LOW QUALITY PROTEIN: regulatory-associated protein of mTOR [KO:K07204]
101343808  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101359268  target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
101345300  LOW QUALITY PROTEIN: proline-rich AKT1 substrate 1 [KO:K16184]
101343535  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
101354510  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101348417  40S ribosomal protein S6 [KO:K02991]
101344707  long-chain-fatty-acid--CoA ligase 5 isoform X1 [KO:K01897] [EC:6.2.1.3]
101357123  long-chain-fatty-acid--CoA ligase 3 isoform X1 [KO:K01897] [EC:6.2.1.3]
101358255  long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
101351601  long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
101353580  long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
101354085  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
101348326  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
101355560  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
101349133  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
101357778  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
101340730  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
101347171  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
101341003  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
101342189  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
101344328  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X2 [KO:K03943] [EC:7.1.1.2]
101352739  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X2 [KO:K03944]
111821539  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
111821167  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
101347434  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
101356399  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
101341663  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
101356177  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101362071  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
101342417  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
101351585  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
101352289  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
101347207  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
101355425  acyl carrier protein, mitochondrial [KO:K03955]
101353746  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
101343020  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
111822042  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
101361940  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
101345814  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
101343512  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
101348161  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
101347019  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
101361585  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
101350430  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
101342802  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
101348157  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
101356612  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
101355955  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
101346167  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
101345302  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
101353065  complex I intermediate-associated protein 30, mitochondrial [KO:K18159]
111820203  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 [KO:K18160]
101353094  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 isoform X2 [KO:K09008]
101347650  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161]
101349023  LOW QUALITY PROTEIN: arginine-hydroxylase NDUFAF5, mitochondrial [KO:K18162] [EC:2.1.1.-]
101360901  NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 isoform X1 [KO:K18163]
101341878  protein arginine methyltransferase NDUFAF7, mitochondrial isoform X1 [KO:K18164]
101344620  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 [KO:K24726]
101357812  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X2 [KO:K00234] [EC:1.3.5.1]
101353562  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
101346550  succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
101348027  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
101349349  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
101359231  cytochrome c1, heme protein, mitochondrial [KO:K00413]
101350351  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
101350954  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
101349519  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
101359862  cytochrome b-c1 complex subunit 7 [KO:K00417]
101353511  cytochrome b-c1 complex subunit 8 [KO:K00418]
101358587  cytochrome b-c1 complex subunit 9 [KO:K00419]
101352977  cytochrome b-c1 complex subunit 10 [KO:K00420]
101346963  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
101351241  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
101357118  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
101343047  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
101358698  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
101358762  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
101357728  cytochrome c oxidase subunit 6B2 [KO:K02267]
101349067  cytochrome c oxidase subunit 6B1 [KO:K02267]
101354643  cytochrome c oxidase subunit 6C [KO:K02268]
101355564  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
101346028  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
101353725  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
101355622  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
101347679  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
111821449  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
101345533  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
111821885  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
101355500  LOW QUALITY PROTEIN: protoheme IX farnesyltransferase, mitochondrial-like [KO:K02257] [EC:2.5.1.141]
101348940  protoheme IX farnesyltransferase, mitochondrial [KO:K02257] [EC:2.5.1.141]
101346394  cytochrome c oxidase assembly protein COX11, mitochondrial isoform X1 [KO:K02258]
101360280  cytochrome c oxidase assembly protein COX14 [KO:K18181]
101361313  cytochrome c oxidase assembly protein COX15 homolog isoform X1 [KO:K02259] [EC:1.17.99.9]
105755970  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial [KO:K18182]
101350126  cytochrome c oxidase copper chaperone [KO:K02260]
101359911  LOW QUALITY PROTEIN: mitochondrial inner membrane protein COX18 [KO:K17797]
101343374  cytochrome c oxidase assembly protein COX19 [KO:K18183]
101354255  cytochrome c oxidase protein 20 homolog isoform X2 [KO:K18184]
101358867  cytochrome c oxidase assembly factor 1 homolog [KO:K18173]
101352336  cytochrome c oxidase assembly factor 3 homolog, mitochondrial [KO:K18175]
101355283  cytochrome c oxidase assembly factor 4 homolog, mitochondrial [KO:K18177]
101341125  cytochrome c oxidase assembly factor 5 [KO:K18178]
101348249  cytochrome c oxidase assembly factor 6 homolog isoform X1 [KO:K18179]
101357021  cytochrome c oxidase assembly factor 7 [KO:K18180]
101357898  ATP synthase subunit alpha, mitochondrial [KO:K02132]
101346922  ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
101354520  ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
101354265  ATP synthase subunit delta, mitochondrial [KO:K02134]
111822811  ATP synthase subunit epsilon, mitochondrial [KO:K02135]
101340662  ATP synthase subunit O, mitochondrial isoform X2 [KO:K02137]
101353320  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
101361354  ATP synthase F(0) complex subunit C1, mitochondrial isoform X2 [KO:K02128]
101359449  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
101356865  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
101355087  ATP synthase subunit d, mitochondrial [KO:K02138]
101353332  ATP synthase subunit e, mitochondrial [KO:K02129]
101346150  ATP synthase subunit f, mitochondrial isoform X1 [KO:K02130]
101359345  ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
101352222  ATP synthase subunit g, mitochondrial [KO:K02140]
101355326  carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
101351898  mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109]
101352788  mitochondrial basic amino acids transporter [KO:K15109]
101360516  carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
101354017  carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
101347610  carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
Compound
C00002  ATP
C00004  NADH
C00008  ADP
C00010  CoA
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00080  H+
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00318  L-Carnitine
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01352  FADH2
C01885  1-Acylglycerol
C02301  O-Acylcarnitine
C02465  Triiodothyronine
C11695  Anandamide
C13856  2-Arachidonoylglycerol
Reference
PMID:27251423
  Authors
Inagaki T, Sakai J, Kajimura S
  Title
Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
  Journal
Nat Rev Mol Cell Biol 17:480-95 (2016)
DOI:10.1038/nrm.2016.62
Reference
PMID:24100998
  Authors
Harms M, Seale P
  Title
Brown and beige fat: development, function and therapeutic potential.
  Journal
Nat Med 19:1252-63 (2013)
DOI:10.1038/nm.3361
Reference
PMID:25154875
  Authors
Boon MR, Kooijman S, van Dam AD, Pelgrom LR, Berbee JF, Visseren CA, van Aggele RC, van den Hoek AM, Sips HC, Lombes M, Havekes LM, Tamsma JT, Guigas B, Meijer OC, Jukema JW, Rensen PC
  Title
Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
  Journal
FASEB J 28:5361-75 (2014)
DOI:10.1096/fj.13-247643
Reference
PMID:26201764
  Authors
Merlin J, Evans BA, Dehvari N, Sato M, Bengtsson T, Hutchinson DS
  Title
Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis.
  Journal
Mol Nutr Food Res 60:18-42 (2016)
DOI:10.1002/mnfr.201500251
Reference
PMID:26271143
  Authors
van Dam AD, Kooijman S, Schilperoort M, Rensen PC, Boon MR
  Title
Regulation of brown fat by AMP-activated protein kinase.
  Journal
Trends Mol Med 21:571-9 (2015)
DOI:10.1016/j.molmed.2015.07.003
Reference
PMID:26482876
  Authors
Kooijman S, van den Heuvel JK, Rensen PC
  Title
Neuronal Control of Brown Fat Activity.
  Journal
Trends Endocrinol Metab 26:657-68 (2015)
DOI:10.1016/j.tem.2015.09.008
Reference
PMID:28448947
  Authors
Contreras C, Nogueiras R, Dieguez C, Rahmouni K, Lopez M
  Title
Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.
  Journal
Redox Biol 12:854-863 (2017)
DOI:10.1016/j.redox.2017.04.019
Reference
PMID:24872083
  Authors
Fruhbeck G, Mendez-Gimenez L, Fernandez-Formoso JA, Fernandez S, Rodriguez A
  Title
Regulation of adipocyte lipolysis.
  Journal
Nutr Res Rev 27:63-93 (2014)
DOI:10.1017/S095442241400002X
Reference
PMID:15545214
  Authors
Tansey JT, Sztalryd C, Hlavin EM, Kimmel AR, Londos C
  Title
The central role of perilipin a in lipid metabolism and adipocyte lipolysis.
  Journal
IUBMB Life 56:379-85 (2004)
DOI:10.1080/15216540400009968
Reference
PMID:20935662
  Authors
Collins S, Yehuda-Shnaidman E, Wang H
  Title
Positive and negative control of Ucp1 gene transcription and the role of beta-adrenergic signaling networks.
  Journal
Int J Obes (Lond) 34 Suppl 1:S28-33 (2010)
DOI:10.1038/ijo.2010.180
Reference
PMID:15964803
  Authors
Robidoux J, Cao W, Quan H, Daniel KW, Moukdar F, Bai X, Floering LM, Collins S
  Title
Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
  Journal
Mol Cell Biol 25:5466-79 (2005)
DOI:10.1128/MCB.25.13.5466-5479.2005
Reference
PMID:27045525
  Authors
Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, Ichijo H
  Title
ASK1 signalling regulates brown and beige adipocyte function.
  Journal
Nat Commun 7:11158 (2016)
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Related
pathway
tmu00020  Citrate cycle (TCA cycle)
tmu00190  Oxidative phosphorylation
tmu04010  MAPK signaling pathway
tmu04022  cGMP-PKG signaling pathway
tmu04024  cAMP signaling pathway
tmu04150  mTOR signaling pathway
tmu04923  Regulation of lipolysis in adipocytes
KO pathway
ko04714   
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