KEGG   PATHWAY: tpal04150
Entry
tpal04150                   Pathway                                
Name
mTOR signaling pathway - Thrips palmi (melon thrips)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
tpal04150  mTOR signaling pathway
tpal04150

Organism
Thrips palmi (melon thrips) [GN:tpal]
Gene
117641107  Y+L amino acid transporter 2-like [KO:K13780]
117641368  large neutral amino acids transporter small subunit 1-like [KO:K13780]
117641487  large neutral amino acids transporter small subunit 2-like isoform X1 [KO:K13780]
117649299  Y+L amino acid transporter 2-like [KO:K13780]
117640544  sodium-coupled neutral amino acid transporter 9 homolog isoform X1 [KO:K14995]
117643615  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
117642283  V-type proton ATPase subunit B [KO:K02147]
117648604  V-type proton ATPase subunit C isoform X1 [KO:K02148]
117653948  LOW QUALITY PROTEIN: V-type proton ATPase subunit D-like [KO:K02149]
117649045  V-type proton ATPase subunit E [KO:K02150]
117641603  V-type proton ATPase subunit F [KO:K02151]
117650699  V-type proton ATPase subunit G [KO:K02152]
117654451  V-type proton ATPase subunit H isoform X1 [KO:K02144]
117647576  ragulator complex protein LAMTOR1 [KO:K20397]
117646066  ragulator complex protein LAMTOR2 [KO:K20398]
117647105  ragulator complex protein LAMTOR3 [KO:K04370]
117643683  ragulator complex protein LAMTOR4 homolog [KO:K20399]
117653407  ragulator complex protein LAMTOR5 homolog [KO:K16344]
117650637  folliculin [KO:K09594]
117650208  folliculin-interacting protein 2 [KO:K20401]
117644129  ras-related GTP-binding protein A [KO:K16185]
117652418  ras-related GTP-binding protein C [KO:K16186]
117649279  GATOR complex protein MIOS-A isoform X1 [KO:K20407]
117648292  nucleoporin SEH1 [KO:K14299]
117649226  GATOR complex protein WDR24 [KO:K20408]
117642205  GATOR complex protein WDR59 isoform X1 [KO:K20409]
117643509  protein SEC13 homolog [KO:K14004]
117644818  GATOR complex protein Iml1 isoform X1 [KO:K20404]
117654195  GATOR complex protein NPRL2 [KO:K20405]
117650567  GATOR complex protein NPRL3 [KO:K20406]
117651666  uncharacterized protein LOC117651666 [KO:K03875]
117651711  uncharacterized protein LOC117651711 [KO:K03875]
117646904  S-phase kinase-associated protein 2-like [KO:K03875]
117652804  uncharacterized protein LOC117652804 [KO:K03875]
117652821  uncharacterized protein LOC117652821 isoform X1 [KO:K03875]
117640645  uncharacterized protein LOC117640645 isoform X1 [KO:K03875]
117647115  S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
117647171  uncharacterized protein LOC117647171 isoform X1 [KO:K03875]
117647967  uncharacterized protein LOC117647967 isoform X1 [KO:K03875]
117648092  uncharacterized protein LOC117648092 [KO:K03875]
117648336  uncharacterized protein LOC117648336 isoform X1 [KO:K03875]
117643161  uncharacterized protein LOC117643161 [KO:K03875]
117649402  uncharacterized protein LOC117649402 [KO:K03875]
117649484  uncharacterized protein LOC117649484 [KO:K03875]
117649901  uncharacterized protein LOC117649901 [KO:K03875]
117644960  uncharacterized protein LOC117644960 [KO:K03875]
117649274  regulatory-associated protein of mTOR isoform X1 [KO:K07204]
117646869  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
117652067  target of rapamycin complex subunit lst8 [KO:K08266]
117639947  TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
117639262  LOW QUALITY PROTEIN: CAP-Gly domain-containing linker protein 1-like [KO:K10421]
117648742  uncharacterized protein LOC117648742 isoform X1 [KO:K10421]
117645670  growth factor receptor-bound protein 14-like [KO:K20064]
117652251  phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
117644815  serine/threonine-protein kinase unc-51 isoform X1 [KO:K08269] [EC:2.7.11.1]
117640829  eukaryotic translation initiation factor 4E-1A-like [KO:K03259]
117648013  eukaryotic translation initiation factor 4E type 2-like isoform X1 [KO:K03259]
117643279  eukaryotic translation initiation factor 4E-like [KO:K03259]
117644318  ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
117641886  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
117645398  40S ribosomal protein S6 [KO:K02991]
117646373  STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
117644392  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
117642784  protein Mo25 [KO:K08272]
117644378  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
117654007  hamartin [KO:K07206]
117649120  tuberin [KO:K07207]
117651512  TBC1 domain family member 7 [KO:K20396]
117646802  GTP-binding protein Rheb homolog isoform X1 [KO:K07208]
117642971  protein wingless-like [KO:K03209]
117643946  protein Wnt-11b-2-like [KO:K00182]
117648618  protein Wnt-4-like isoform X1 [KO:K00408]
117642187  protein Wnt-5b-like [KO:K00444]
117642951  protein Wnt-7b-like [KO:K00572]
117654129  protein Wnt-8a-like isoform X1 [KO:K00714]
117642972  protein Wnt-10b-like [KO:K01357]
117645150  protein Wnt-16-like [KO:K01558]
117639435  frizzled-2 [KO:K02432]
117638956  frizzled-4-like [KO:K02354]
117650645  frizzled-5 [KO:K02375]
117648086  low-density lipoprotein receptor-related protein 6 [KO:K03068]
117643584  segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
117643604  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K07209] [EC:2.7.11.10]
117650332  LIRP [KO:K04526]
117650333  LIRP-like isoform X1 [KO:K04526]
117650445  uncharacterized protein LOC117650445 [KO:K05459]
117651912  insulin-like growth factor 1 receptor [KO:K04527] [EC:2.7.10.1]
117644255  LOW QUALITY PROTEIN: insulin receptor-like [KO:K04527] [EC:2.7.10.1]
117641970  uncharacterized protein LOC117641970 [KO:K05087] [EC:2.7.10.1]
117646031  protein enhancer of sevenless 2B [KO:K04364]
117641737  protein son of sevenless [KO:K03099]
117642186  ras-like protein [KO:K07827]
117648016  GTPase HRas [KO:K07827]
117641560  raf homolog serine/threonine-protein kinase Raf [KO:K04365] [EC:2.7.11.1]
117645021  dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]
117649831  ribosomal protein S6 kinase 2 beta-like isoform X1 [KO:K04373] [EC:2.7.11.1]
117647689  mucin-12 isoform X1 [KO:K16172]
117651645  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117649659  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
117654422  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117651310  3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
117640730  RAC serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117640962  target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
117645968  rapamycin-insensitive companion of mTOR [KO:K08267]
117639766  ras-like GTP-binding protein Rho1 isoform X1 [KO:K04513]
117651929  protein kinase C, brain isozyme isoform X1 [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
tpal00561  Glycerolipid metabolism
tpal04140  Autophagy - animal
KO pathway
ko04150   
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