KEGG   PATHWAY: tsr00010
Entry
tsr00010                    Pathway                                
Name
Glycolysis / Gluconeogenesis - Thamnophis sirtalis (common garter snake)
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
tsr00010  Glycolysis / Gluconeogenesis
tsr00010

Module
tsr_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:tsr00010]
tsr_M00002  Glycolysis, core module involving three-carbon compounds [PATH:tsr00010]
tsr_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:tsr00010]
tsr_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:tsr00010]
Other DBs
GO: 0006096 0006094
Organism
Thamnophis sirtalis (common garter snake) [GN:tsr]
Gene
106551888  hexokinase-1 [KO:K00844] [EC:2.7.1.1]
106541043  hexokinase-2-like [KO:K00844] [EC:2.7.1.1]
106549297  hexokinase-3-like [KO:K00844] [EC:2.7.1.1]
106551319  HKDC1; putative hexokinase HKDC1 [KO:K00844] [EC:2.7.1.1]
106539501  putative hexokinase HKDC1 [KO:K00844] [EC:2.7.1.1]
106547695  GCK; LOW QUALITY PROTEIN: glucokinase [KO:K12407] [EC:2.7.1.2]
106557345  GPI; LOW QUALITY PROTEIN: glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
106552271  PFKM; ATP-dependent 6-phosphofructokinase, muscle type [KO:K00850] [EC:2.7.1.11]
106543787  PFKP; ATP-dependent 6-phosphofructokinase, platelet type [KO:K00850] [EC:2.7.1.11]
106537603  PFKL; ATP-dependent 6-phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]
106550964  fructose-1,6-bisphosphatase 1-like [KO:K03841] [EC:3.1.3.11]
106550965  fructose-1,6-bisphosphatase isozyme 2-like [KO:K03841] [EC:3.1.3.11]
106556343  fructose-bisphosphate aldolase C [KO:K01623] [EC:4.1.2.13]
106546547  uncharacterized protein LOC106546547 [KO:K01623] [EC:4.1.2.13]
106552645  fructose-bisphosphate aldolase B [KO:K01623] [EC:4.1.2.13]
106552425  TPI1; triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
106549842  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
106551772  glyceraldehyde-3-phosphate dehydrogenase 2 [KO:K10705] [EC:1.2.1.12]
106544469  PGK1; phosphoglycerate kinase 1 [KO:K00927] [EC:2.7.2.3]
106549041  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
106555509  phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
106556629  ENO3; beta-enolase [KO:K01689] [EC:4.2.1.11]
106555232  gamma-enolase-like [KO:K01689] [EC:4.2.1.11]
106541942  ENO4; enolase-like protein ENO4 isoform X1 [KO:K27394] [EC:4.2.1.11]
106538728  pyruvate kinase PKM [KO:K00873] [EC:2.7.1.40]
106544312  pyruvate kinase PKLR-like [KO:K12406] [EC:2.7.1.40]
106554165  PDHA1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial [KO:K00161] [EC:1.2.4.1]
106550844  PDHB; pyruvate dehydrogenase E1 component subunit beta, mitochondrial [KO:K00162] [EC:1.2.4.1]
106552462  DLAT; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial [KO:K00627] [EC:2.3.1.12]
106553094  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
106546355  L-lactate dehydrogenase A chain [KO:K00016] [EC:1.1.1.27]
106549810  L-lactate dehydrogenase B chain [KO:K00016] [EC:1.1.1.27]
106549700  alcohol dehydrogenase 1 [KO:K13951] [EC:1.1.1.1]
106540716  alcohol dehydrogenase 1-like [KO:K13951] [EC:1.1.1.1]
106540717  alcohol dehydrogenase 1-like isoform X1 [KO:K13951] [EC:1.1.1.1]
106540718  alcohol dehydrogenase 1A-like isoform X1 [KO:K13951] [EC:1.1.1.1]
106556012  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
106546846  AKR1A1; alcohol dehydrogenase [NADP(+)] [KO:K00002] [EC:1.1.1.2]
106552564  ALDH3A2; fatty aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
106553610  aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
106538714  ALDH16A1; aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
106537542  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
106553466  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
106538896  aldehyde dehydrogenase family 3 member B1-like [KO:K00129] [EC:1.2.1.5]
106538897  ALDH3B1; aldehyde dehydrogenase family 3 member B1 [KO:K00129] [EC:1.2.1.5]
106548577  acetyl-coenzyme A synthetase 2-like, mitochondrial [KO:K01895] [EC:6.2.1.1]
106554617  ACSS2; acetyl-coenzyme A synthetase, cytoplasmic [KO:K01895] [EC:6.2.1.1]
106543261  acetyl-coenzyme A synthetase 2-like, mitochondrial isoform X1 [KO:K01895] [EC:6.2.1.1]
106546379  PGM1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
106554452  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
106540287  glucose-6-phosphatase-like [KO:K01084] [EC:3.1.3.9]
106540289  glucose-6-phosphatase-like [KO:K01084] [EC:3.1.3.9]
106552367  G6PC3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
106551694  ADPGK; ADP-dependent glucokinase [KO:K08074] [EC:2.7.1.147]
106545025  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
106551602  MINPP1; multiple inositol polyphosphate phosphatase 1 [KO:K03103] [EC:3.1.3.62 3.1.3.80]
106540961  phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [KO:K01596] [EC:4.1.1.32]
106551437  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00085  D-Fructose 6-phosphate
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00354  D-Fructose 1,6-bisphosphate
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
tsr00020  Citrate cycle (TCA cycle)
tsr00030  Pentose phosphate pathway
tsr00500  Starch and sucrose metabolism
tsr00620  Pyruvate metabolism
tsr00640  Propanoate metabolism
KO pathway
ko00010   
LinkDB

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