KEGG   PATHWAY: uah03420
Entry
uah03420                    Pathway                                
Name
Nucleotide excision repair - Ursus arctos horribilis (North American brown bear)
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
uah03420  Nucleotide excision repair
uah03420

Other DBs
GO: 0006289
Organism
Ursus arctos horribilis (North American brown bear) [GN:uah]
Gene
113241739  RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 [KO:K03868] [EC:2.3.2.32]
113270912  CUL4B; cullin-4B isoform X1 [KO:K10609]
113247585  CUL4A; cullin-4A isoform X1 [KO:K10609]
113249012  cullin-4B-like [KO:K10609]
113246913  DDB1; DNA damage-binding protein 1 [KO:K10610]
113264969  DDB2; DNA damage-binding protein 2 [KO:K10140]
113257224  XPC; DNA repair protein complementing XP-C cells [KO:K10838]
113260344  RAD23B; UV excision repair protein RAD23 homolog B isoform X1 [KO:K10839]
113247209  RAD23A; UV excision repair protein RAD23 homolog A isoform X1 [KO:K10839]
113246812  CETN2; centrin-2 isoform X1 [KO:K10840]
113255300  ERCC8; DNA excision repair protein ERCC-8 isoform X1 [KO:K10570]
113243113  ERCC6; DNA excision repair protein ERCC-6 isoform X1 [KO:K10841]
113245730  UVSSA; UV-stimulated scaffold protein A isoform X1 [KO:K23720]
113271138  POLR2A; DNA-directed RNA polymerase II subunit RPB1 [KO:K03006] [EC:2.7.7.6]
113262531  POLR2B; DNA-directed RNA polymerase II subunit RPB2 [KO:K03010] [EC:2.7.7.6]
113252287  POLR2C; DNA-directed RNA polymerase II subunit RPB3 [KO:K03011]
113263493  POLR2D; DNA-directed RNA polymerase II subunit RPB4 [KO:K03012]
113242719  POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1 [KO:K03013]
113241794  POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 [KO:K03014]
113246998  POLR2G; DNA-directed RNA polymerase II subunit RPB7 [KO:K03015]
113254312  POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 [KO:K03016]
113244837  POLR2I; DNA-directed RNA polymerase II subunit RPB9 isoform X1 [KO:K03017]
113249366  DNA-directed RNA polymerases I, II, and III subunit RPABC5 [KO:K03007]
113249372  DNA-directed RNA polymerases I, II, and III subunit RPABC5 [KO:K03007]
113252878  POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4 isoform X1 [KO:K03009]
113267821  POLR2J; DNA-directed RNA polymerase II subunit RPB11-a [KO:K03008]
113269673  POLR2M; protein GRINL1A [KO:K21987]
113255256  CDK7; cyclin-dependent kinase 7 isoform X1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
113242407  MNAT1; CDK-activating kinase assembly factor MAT1 isoform X1 [KO:K10842]
113255129  CCNH; cyclin-H isoform X1 [KO:K06634]
113263481  ERCC3; general transcription and DNA repair factor IIH helicase subunit XPB [KO:K10843] [EC:5.6.2.4]
113243432  ERCC2; general transcription and DNA repair factor IIH helicase subunit XPD [KO:K10844] [EC:5.6.2.3]
113259602  GTF2H5; general transcription factor IIH subunit 5 [KO:K10845]
113265128  GTF2H1; general transcription factor IIH subunit 1 isoform X1 [KO:K03141]
113255248  general transcription factor IIH subunit 2 [KO:K03142]
113266889  GTF2H3; general transcription factor IIH subunit 3 isoform X1 [KO:K03143]
113264346  GTF2H4; general transcription factor IIH subunit 4 [KO:K03144]
113251518  DNA repair protein complementing XP-G cells isoform X1 [KO:K10846]
113260427  XPA; DNA repair protein complementing XP-A cells [KO:K10847]
113269132  RPA1; replication protein A 70 kDa DNA-binding subunit isoform X1 [KO:K07466]
113268426  RPA2; replication protein A 32 kDa subunit [KO:K10739]
113260519  RPA3; replication protein A 14 kDa subunit [KO:K10740]
113244285  RPA4; replication protein A 30 kDa subunit [KO:K10741]
113270777  ERCC4; DNA repair endonuclease XPF [KO:K10848] [EC:3.1.-.-]
113243429  ERCC1; DNA excision repair protein ERCC-1 isoform X1 [KO:K10849]
113247242  POLD1; DNA polymerase delta catalytic subunit isoform X1 [KO:K02327] [EC:2.7.7.7]
113257896  POLD2; DNA polymerase delta subunit 2 [KO:K02328]
113269314  POLD3; DNA polymerase delta subunit 3 isoform X1 [KO:K03504]
113244035  POLD4; DNA polymerase delta subunit 4 [KO:K03505]
113266839  POLE; DNA polymerase epsilon catalytic subunit A [KO:K02324] [EC:2.7.7.7]
113266191  POLE2; DNA polymerase epsilon subunit 2 isoform X1 [KO:K02325] [EC:2.7.7.7]
113266321  POLE3; DNA polymerase epsilon subunit 3 [KO:K02326] [EC:2.7.7.7]
113243417  POLE4; DNA polymerase epsilon subunit 4 isoform X1 [KO:K03506] [EC:2.7.7.7]
113258365  PCNA; proliferating cell nuclear antigen [KO:K04802]
113262419  RFC1; replication factor C subunit 1 isoform X1 [KO:K10754]
113267778  RFC2; replication factor C subunit 2 [KO:K10755]
113253907  RFC4; replication factor C subunit 4 [KO:K10755]
113251252  RFC3; replication factor C subunit 3 [KO:K10756]
113267017  RFC5; replication factor C subunit 5 isoform X1 [KO:K10756]
113243358  LIG1; DNA ligase 1 isoform X1 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
uah03020  RNA polymerase
uah04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   
LinkDB

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