Entry
Name
Regulation of lipolysis in adipocytes - Vulpes lagopus (Arctic fox)
Description
Lipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs as energy substrates, is a unique function of white adipose tissue. Lipolysis is under tight hormonal control. During fasting, catecholamines, by binding to Gs-coupled-adrenergic receptors (-AR), activate adenylate cyclase (AC) to increase cAMP and activate protein kinase A (PKA). PKA phosphorylates target protein such as hormone-sensitive lipase (HSL) and perilipin 1 (PLIN). PLIN phosphorylation is a key event in the sequential activation of TAG hydrolysis involving adipose triglyceride lipase (ATGL), HSL, and monoglyceride lipase (MGL). During the fed state, insulin, through activation of phosphodiesterase-3B (PDE-3B), inhibits catecholamine-induced lipolysis via the degradation of cAMP.
Class
Organismal Systems; Endocrine system
BRITE hierarchy
Pathway map
vlg04923 Regulation of lipolysis in adipocytes
Ortholog table
Other DBs
Organism
Vulpes lagopus (Arctic fox) [GN:
vlg ]
Gene
121477898 guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632 ]
121477352 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
121478805 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
121499678 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
121481416 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
121496480 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
121494738 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
121488334 PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260 ]
121471255 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
121487463 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
121495419 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
Compound
Reference
Authors
Ahmadian M, Wang Y, Sul HS
Title
Lipolysis in adipocytes.
Journal
Reference
Authors
Ahmadian M, Duncan RE, Sul HS
Title
The skinny on fat: lipolysis and fatty acid utilization in adipocytes.
Journal
Reference
Authors
Wang S, Soni KG, Semache M, Casavant S, Fortier M, Pan L, Mitchell GA
Title
Lipolysis and the integrated physiology of lipid energy metabolism.
Journal
Reference
Authors
Lafontan M
Title
Historical perspectives in fat cell biology: the fat cell as a model for the investigation of hormonal and metabolic pathways.
Journal
Reference
Authors
Fruhbeck G, Mendez-Gimenez L, Fernandez-Formoso JA, Fernandez S, Rodriguez A
Title
Regulation of adipocyte lipolysis.
Journal
Reference
Authors
Proenca AR, Sertie RA, Oliveira AC, Campana AB, Caminhotto RO, Chimin P, Lima FB
Title
New concepts in white adipose tissue physiology.
Journal
Reference
Authors
Duncan RE, Ahmadian M, Jaworski K, Sarkadi-Nagy E, Sul HS
Title
Regulation of lipolysis in adipocytes.
Journal
Reference
Authors
Lafontan M
Title
Advances in adipose tissue metabolism.
Journal
Reference
Authors
Jaworski K, Sarkadi-Nagy E, Duncan RE, Ahmadian M, Sul HS
Title
Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue.
Journal
Reference
Authors
Thompson D, Karpe F, Lafontan M, Frayn K
Title
Physical activity and exercise in the regulation of human adipose tissue physiology.
Journal
Reference
Authors
Lafontan M, Langin D
Title
Lipolysis and lipid mobilization in human adipose tissue.
Journal
Reference
Authors
Arner P, Langin D
Title
Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance.
Journal
Reference
Authors
Brasaemle DL
Title
Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis.
Journal
Reference
Authors
Lampidonis AD, Rogdakis E, Voutsinas GE, Stravopodis DJ
Title
The resurgence of Hormone-Sensitive Lipase (HSL) in mammalian lipolysis.
Journal
Reference
Authors
Bickel PE, Tansey JT, Welte MA
Title
PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores.
Journal
Reference
Authors
Grahn THM, Kaur R, Yin J, Schweiger M, Sharma VM, Lee MJ, Ido Y, Smas CM, Zechner R, Lass A, Puri V
Title
Fat-specific protein 27 (FSP27) interacts with adipose triglyceride lipase (ATGL) to regulate lipolysis and insulin sensitivity in human adipocytes.
Journal
Related pathway
KO pathway
LinkDB
All DBs