KEGG   PATHWAY: ypc00260
Entry
ypc00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Yersinia pseudotuberculosis 1
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ypc00260  Glycine, serine and threonine metabolism
ypc00260

Module
ypc_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ypc00260]
ypc_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ypc00260]
ypc_M00555  Betaine biosynthesis, choline => betaine [PATH:ypc00260]
ypc_M00621  Glycine cleavage system [PATH:ypc00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Yersinia pseudotuberculosis 1 [GN:ypc]
Gene
BZ23_3259  aspartate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]
BZ23_79  aspartate kinase domain protein [KO:K12524] [EC:2.7.2.4 1.1.1.3]
BZ23_3721  aspartate kinase domain protein [KO:K12525] [EC:2.7.2.4 1.1.1.3]
BZ23_3415  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BZ23_80  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
BZ23_81  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
BZ23_993  ltaE; low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
BZ23_2452  beta-eliminating lyase family protein [KO:K00600] [EC:2.1.2.1]
BZ23_3560  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BZ23_3447  glycerate kinase family protein [KO:K00865] [EC:2.7.1.165]
BZ23_758  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
BZ23_74  putative phosphoglycerate mutase gpmB [KO:K15634] [EC:5.4.2.11]
BZ23_3676  gpmI; phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
BZ23_926  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BZ23_2753  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BZ23_1025  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
BZ23_61  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
BZ23_1763  ydfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
BZ23_3672  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
BZ23_3673  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BZ23_2744  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
BZ23_2746  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
BZ23_192  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BZ23_3736  glucose inhibited division A family protein [KO:K00382] [EC:1.8.1.4]
BZ23_2745  gcvH; glycine cleavage system H protein [KO:K02437]
BZ23_373  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
BZ23_789  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BZ23_790  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BZ23_1275  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BZ23_3763  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
BZ23_3570  pyridoxal-phosphate dependent enzyme family protein [KO:K01754] [EC:4.3.1.19]
BZ23_2205  aspartate racemase family protein [KO:K25316] [EC:5.1.1.10]
BZ23_1967  alr; alanine racemase [KO:K25317] [EC:5.1.1.10]
BZ23_1690  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
BZ23_1691  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
BZ23_1158  beta-eliminating lyase family protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ypc00010  Glycolysis / Gluconeogenesis
ypc00020  Citrate cycle (TCA cycle)
ypc00230  Purine metabolism
ypc00250  Alanine, aspartate and glutamate metabolism
ypc00270  Cysteine and methionine metabolism
ypc00290  Valine, leucine and isoleucine biosynthesis
ypc00300  Lysine biosynthesis
ypc00330  Arginine and proline metabolism
ypc00460  Cyanoamino acid metabolism
ypc00470  D-Amino acid metabolism
ypc00564  Glycerophospholipid metabolism
ypc00600  Sphingolipid metabolism
ypc00620  Pyruvate metabolism
ypc00630  Glyoxylate and dicarboxylate metabolism
ypc00640  Propanoate metabolism
ypc00680  Methane metabolism
ypc00860  Porphyrin metabolism
ypc00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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