KEGG   PATHWAY: ypd00260
Entry
ypd00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Yersinia pestis D106004
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ypd00260  Glycine, serine and threonine metabolism
ypd00260

Module
ypd_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ypd00260]
ypd_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ypd00260]
ypd_M00555  Betaine biosynthesis, choline => betaine [PATH:ypd00260]
ypd_M00621  Glycine cleavage system [PATH:ypd00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Yersinia pestis D106004 [GN:ypd]
Gene
YPD4_3271  lysC; aspartate kinase III [KO:K00928] [EC:2.7.2.4]
YPD4_0398  bifunctional aspartokinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
YPD4_0100  metL; bifunctional aspartate kinase II/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
YPD4_3473  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
YPD4_0400  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
YPD4_0401  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
YPD4_1202  ltaA; L-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
YPD4_2288  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
YPD4_3590  2-hydroxyacid dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
YPD4_3501  glxK; putative glycerate kinase [KO:K00865] [EC:2.7.1.165]
YPD4_0986  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
YPD4_0394  gpmB; phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
YPD4_0060  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
YPD4_0767  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
YPD4_1138  D-isomer specific 2-hydroxyacid dehydrogenase family protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
YPD4_1233  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
YPD4_0381  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
YPD4_0055  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
YPD4_0056  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
YPD4_0776  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
YPD4_0774  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
YPD4_3001  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
YPD4_3451  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
YPD4_0775  gcsH; glycine cleavage system protein H [KO:K02437]
YPD4_2865  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
YPD4_1014  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
YPD4_1015  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
YPD4_1569  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
YPD4_3432  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
YPD4_3600  hypothetical protein [KO:K01754] [EC:4.3.1.19]
YPD4_2531  resistance protein [KO:K25316] [EC:5.1.1.10]
YPD4_2054  alr; alanine racemase [KO:K25317] [EC:5.1.1.10]
YPD4_1937  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
YPD4_1938  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
YPD4_1360  putative decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ypd00010  Glycolysis / Gluconeogenesis
ypd00020  Citrate cycle (TCA cycle)
ypd00230  Purine metabolism
ypd00250  Alanine, aspartate and glutamate metabolism
ypd00270  Cysteine and methionine metabolism
ypd00290  Valine, leucine and isoleucine biosynthesis
ypd00300  Lysine biosynthesis
ypd00330  Arginine and proline metabolism
ypd00460  Cyanoamino acid metabolism
ypd00470  D-Amino acid metabolism
ypd00564  Glycerophospholipid metabolism
ypd00600  Sphingolipid metabolism
ypd00620  Pyruvate metabolism
ypd00630  Glyoxylate and dicarboxylate metabolism
ypd00640  Propanoate metabolism
ypd00680  Methane metabolism
ypd00860  Porphyrin metabolism
ypd00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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