KEGG   PATHWAY: yps00260
Entry
yps00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Yersinia pseudotuberculosis IP 32953 (serotype I)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
yps00260  Glycine, serine and threonine metabolism
yps00260

Module
yps_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:yps00260]
yps_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:yps00260]
yps_M00555  Betaine biosynthesis, choline => betaine [PATH:yps00260]
yps_M00621  Glycine cleavage system [PATH:yps00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Yersinia pseudotuberculosis IP 32953 (serotype I) [GN:yps]
Gene
YPTB3650  lysC; lysine-sensitive aspartokinase III [KO:K00928] [EC:2.7.2.4]
YPTB0602  thrA; bifunctional ThrA; aspartokinase I and homoserine dehydrogenase I (C-terminal) [KO:K12524] [EC:2.7.2.4 1.1.1.3]
YPTB0106  metM; bifunctional aspartokinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
YPTB3790  asd; aspartate semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
YPTB0603  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
YPTB0604  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
YPTB1383  ltaA; L-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
YPTB2869  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
YPTB3910  putative D-isomer specific 2-hydroxyacid dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
YPTB3821  glxK; putative glycerate kinase [KO:K00865] [EC:2.7.1.165]
YPTB1166  gpmA; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
YPTB0598  gpmB; putative phosphoglycerate mutase 2 [KO:K15634] [EC:5.4.2.11]
YPTB0060  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
YPTB1320  putative D-isomer specific 2-hydroxyacid dehydrogenase family... [KO:K00058] [EC:1.1.1.95 1.1.1.399]
YPTB3189  serA; D-3-phosphoglycerate dehydrogenase (PGDH) [KO:K00058] [EC:1.1.1.95 1.1.1.399]
YPTB1414  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
YPTB0586  serB; 3-phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
YPTB2195  ydfG; probable oxidoreductase in dcp-nohA intergenic region [KO:K16066] [EC:1.1.1.381 1.1.1.-]
YPTB0056  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
YPTB0057  tdh; threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
YPTB3180  gcvP; Glycine cleavage system P-protein. [KO:K00281] [EC:1.4.4.2]
YPTB3182  gcvT; Glycine cleavage system T-protein [KO:K00605] [EC:2.1.2.10]
YPTB0118  putative pyridine nucleotide-disulphide oxidoreductase [KO:K00382] [EC:1.8.1.4]
YPTB0715  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
YPTB3181  gcsH; glycine cleavage system H protein. [KO:K02437]
YPTB0850  pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
YPTB1195  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
YPTB1196  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
YPTB1647  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
YPTB0138  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
YPTB3901  pyridoxal-phosphate dependent enzyme [KO:K01754] [EC:4.3.1.19]
YPTB2625  putative aspartate/glutamate racemase [KO:K25316] [EC:5.1.1.10]
YPTB2392  putative alanine racemase [KO:K25317] [EC:5.1.1.10]
YPTB2125  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
YPTB2126  trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
YPTB1541  putative decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
yps00010  Glycolysis / Gluconeogenesis
yps00020  Citrate cycle (TCA cycle)
yps00230  Purine metabolism
yps00250  Alanine, aspartate and glutamate metabolism
yps00270  Cysteine and methionine metabolism
yps00290  Valine, leucine and isoleucine biosynthesis
yps00300  Lysine biosynthesis
yps00330  Arginine and proline metabolism
yps00460  Cyanoamino acid metabolism
yps00470  D-Amino acid metabolism
yps00564  Glycerophospholipid metabolism
yps00600  Sphingolipid metabolism
yps00620  Pyruvate metabolism
yps00630  Glyoxylate and dicarboxylate metabolism
yps00640  Propanoate metabolism
yps00680  Methane metabolism
yps00860  Porphyrin metabolism
yps00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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