KEGG   PATHWAY: zce04150
Entry
zce04150                    Pathway                                
Name
mTOR signaling pathway - Zerene cesonia (dogface butterfly)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
zce04150  mTOR signaling pathway
zce04150

Organism
Zerene cesonia (dogface butterfly) [GN:zce]
Gene
119840692  large neutral amino acids transporter small subunit 2 [KO:K13780]
119835640  Y+L amino acid transporter 2 [KO:K13780]
119840083  large neutral amino acids transporter small subunit 1 [KO:K13780]
119828406  uncharacterized protein LOC119828406 isoform X1 [KO:K06519]
119840154  sodium-coupled neutral amino acid transporter 9 homolog [KO:K14995]
119833081  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
119837925  V-type proton ATPase subunit B [KO:K02147]
119836670  V-type proton ATPase subunit C [KO:K02148]
119832886  V-type proton ATPase subunit D [KO:K02149]
119839692  V-type proton ATPase subunit D-like [KO:K02149]
119829125  V-type proton ATPase subunit E [KO:K02150]
119838380  V-type proton ATPase subunit F [KO:K02151]
119836968  V-type proton ATPase subunit G [KO:K02152]
119839854  V-type proton ATPase subunit H isoform X1 [KO:K02144]
119832558  ragulator complex protein LAMTOR2 homolog [KO:K20398]
119840014  ragulator complex protein LAMTOR3 homolog [KO:K04370]
119830674  ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
119840450  ragulator complex protein LAMTOR5 [KO:K16344]
119840862  folliculin [KO:K09594]
119831131  folliculin-interacting protein 2 isoform X1 [KO:K20401]
119830269  ras-related GTP-binding protein A [KO:K16185]
119829709  ras-related GTP-binding protein C [KO:K16186]
119838737  GATOR complex protein MIOS-B [KO:K20407]
119832025  nucleoporin SEH1 [KO:K14299]
119838629  GATOR complex protein WDR24 [KO:K20408]
119830626  GATOR complex protein WDR59 [KO:K20409]
119828853  protein SEC13 homolog [KO:K14004]
119834795  GATOR complex protein Iml1 isoform X1 [KO:K20404]
119835873  GATOR complex protein NPRL2-like isoform X1 [KO:K20405]
119838709  GATOR complex protein NPRL2-like [KO:K20405]
119832910  GATOR complex protein NPRL3 [KO:K20406]
119839245  S-phase kinase-associated protein 2-like isoform X1 [KO:K03875]
119832407  protein raptor homolog [KO:K07204]
119839901  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
119840316  serine/threonine-protein kinase Tor-like [KO:K07203] [EC:2.7.11.1]
119838749  target of rapamycin complex subunit lst8 [KO:K08266]
119837865  TELO2-interacting protein 1 homolog [KO:K20403]
119834909  CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
119829282  phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
119830688  serine/threonine-protein kinase unc-51 isoform X1 [KO:K08269] [EC:2.7.11.1]
119831071  eukaryotic translation initiation factor 4E1-like [KO:K03259]
119838648  eukaryotic translation initiation factor 4E type 2 [KO:K03259]
119835168  ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
119838333  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
119839554  40S ribosomal protein S6 [KO:K02991]
119834608  STE20-related kinase adapter protein alpha-like [KO:K08271]
119834687  STE20-related kinase adapter protein alpha-like [KO:K08271]
119831145  serine/threonine-protein kinase stk11 isoform X1 [KO:K07298] [EC:2.7.11.1]
119829924  protein Mo25 [KO:K08272]
119835105  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
119832406  tuberin [KO:K07207]
119837946  TBC1 domain family member 7 [KO:K20396]
119831331  GTP-binding protein Rheb homolog [KO:K07208]
119831883  protein Wnt-1 [KO:K03209]
119836640  protein Wnt-4-like [KO:K00408]
119836673  protein Wnt-5b-like [KO:K00444]
119831404  protein Wnt-6 [KO:K00445]
119836743  protein Wnt-7b-like isoform X1 [KO:K00572]
119830612  protein Wnt-4 [KO:K01064]
119836757  protein Wnt-10a [KO:K01357]
119836858  protein Wnt-10a-like [KO:K01357]
119830465  protein Wnt-11-like [KO:K01384]
119840505  frizzled-7-B [KO:K02432]
119839954  frizzled-4 [KO:K02354]
119840744  frizzled-2 [KO:K02375]
119839934  frizzled-10-like [KO:K02842]
119833337  low-density lipoprotein receptor-related protein 5 [KO:K03068]
119838872  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
119832823  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
119840923  bombyxin A-1 homolog [KO:K04526]
119830987  bombyxin A-3 homolog [KO:K04526]
119838279  bombyxin G-1 [KO:K04526]
119838563  uncharacterized protein LOC119838563 [KO:K04526]
119833516  bombyxin A-2 homolog [KO:K04526]
119832984  insulin-like growth factor 1 receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
119829235  insulin-like growth factor 1 receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
119832686  growth factor receptor-bound protein 2 [KO:K04364]
119838099  protein son of sevenless [KO:K03099]
119839147  GTPase HRas [KO:K07827]
119830135  raf homolog serine/threonine-protein kinase Raf isoform X1 [KO:K04365] [EC:2.7.11.1]
119839600  dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]
119835138  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119833750  ribosomal protein S6 kinase 2 beta [KO:K04373] [EC:2.7.11.1]
119840245  insulin receptor substrate 1 isoform X1 [KO:K16172]
119834537  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
119834797  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
119840251  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119840677  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
119828358  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
119832809  RAC serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
119832980  RAC serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
119830378  stress-activated map kinase-interacting protein 1 [KO:K20410]
119831289  rapamycin-insensitive companion of mTOR-like [KO:K08267]
119832103  ras-like GTP-binding protein Rho1 isoform X1 [KO:K04513]
119830985  protein kinase C, brain isozyme [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
zce00561  Glycerolipid metabolism
zce04140  Autophagy - animal
KO pathway
ko04150   
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