KEGG   PATHWAY: zne04150
Entry
zne04150                    Pathway                                
Name
mTOR signaling pathway - Zootermopsis nevadensis (dampwood termite)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
zne04150  mTOR signaling pathway
zne04150

Organism
Zootermopsis nevadensis (dampwood termite) [GN:zne]
Gene
110837060  Y+L amino acid transporter 2 [KO:K13780]
110837056  large neutral amino acids transporter small subunit 1 [KO:K13780]
110833433  sodium-coupled neutral amino acid transporter 9-like [KO:K14995]
110826824  V-type proton ATPase catalytic subunit A isoform X1 [KO:K02145] [EC:7.1.2.2]
110839292  V-type proton ATPase subunit B [KO:K02147]
110837855  V-type proton ATPase subunit C [KO:K02148]
110835641  V-type proton ATPase subunit D 1 [KO:K02149]
110833370  V-type proton ATPase subunit E isoform X1 [KO:K02150]
110840220  V-type proton ATPase subunit F [KO:K02151]
110836920  V-type proton ATPase subunit G [KO:K02152]
110836185  V-type proton ATPase subunit H isoform X1 [KO:K02144]
110832260  ragulator complex protein LAMTOR1 isoform X1 [KO:K20397]
110830270  ragulator complex protein LAMTOR2 homolog [KO:K20398]
110831046  ragulator complex protein LAMTOR3 [KO:K04370]
110827279  ragulator complex protein LAMTOR4 homolog [KO:K20399]
110831376  ragulator complex protein LAMTOR5-like [KO:K16344]
110834022  folliculin isoform X1 [KO:K09594]
110835981  uncharacterized protein LOC110835981 [KO:K20401]
110837558  ras-related GTP-binding protein A [KO:K16185]
110832680  ras-related GTP-binding protein C isoform X1 [KO:K16186]
110832854  GATOR complex protein MIOS [KO:K20407]
110837463  nucleoporin SEH1 isoform X1 [KO:K14299]
110832855  GATOR complex protein WDR24 isoform X1 [KO:K20408]
110833675  GATOR complex protein WDR59-like isoform X1 [KO:K20409]
110831431  protein SEC13 homolog [KO:K14004]
110833291  GATOR complex protein DEPDC5 [KO:K20404]
110833435  GATOR complex protein NPRL2 [KO:K20405]
110839250  GATOR complex protein NPRL2-like isoform X1 [KO:K20405]
110839466  GATOR complex protein NPRL3 isoform X1 [KO:K20406]
110828413  S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
110832472  regulatory-associated protein of mTOR [KO:K07204]
110840625  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
110840894  target of rapamycin complex subunit lst8 isoform X1 [KO:K08266]
110828803  TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
110827481  CAP-Gly domain-containing linker protein 1-like [KO:K10421]
110832662  phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
110840817  serine/threonine-protein kinase unc-51 [KO:K08269] [EC:2.7.11.1]
110837313  eukaryotic translation initiation factor 4E-like [KO:K03259]
110838411  eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
110838355  ribosomal protein S6 kinase beta-2-like isoform X1 [KO:K04688] [EC:2.7.11.1]
110840646  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
110834750  40S ribosomal protein S6 [KO:K02991]
110828360  STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
110832701  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
110829804  protein Mo25 [KO:K08272]
110828230  5'-AMP-activated protein kinase catalytic subunit alpha-2-like [KO:K07198] [EC:2.7.11.31]
110828006  hamartin [KO:K07206]
110832471  tuberin [KO:K07207]
110838749  TBC1 domain family member 7 [KO:K20396]
110836908  GTP-binding protein Rheb homolog [KO:K07208]
110828860  LOW QUALITY PROTEIN: protein wingless [KO:K03209]
110832362  protein Wnt-1-like isoform X1 [KO:K00408]
110837886  protein Wnt-5b-like isoform X1 [KO:K00444]
110828845  protein Wnt-6-like [KO:K00445]
110840788  LOW QUALITY PROTEIN: protein Wnt-2-like [KO:K00572]
110828857  protein Wnt-4-like [KO:K01064]
110828861  protein Wnt-10a [KO:K01357]
110827247  protein Wnt-11b-2-like [KO:K01384]
110832567  protein Wnt-16-like [KO:K01558]
110839804  frizzled-2 [KO:K02432]
110839656  frizzled-4-like [KO:K02354]
110827592  LOW QUALITY PROTEIN: frizzled-2-like [KO:K02375]
110839641  frizzled-10-like [KO:K02842]
110839428  low-density lipoprotein receptor-related protein 6 [KO:K03068]
110827516  segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
110828127  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
110829699  LIRP-like [KO:K04526]
110832106  LIRP-like [KO:K04526]
110832107  LIRP-like [KO:K04526]
110832108  LIRP-like [KO:K04526]
110835119  insulin-like receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
110836794  protein enhancer of sevenless 2B [KO:K04364]
110832971  LOW QUALITY PROTEIN: protein son of sevenless-like [KO:K03099]
110839079  GTPase HRas [KO:K07827]
110839080  GTPase HRas [KO:K07827]
110839890  GTPase HRas [KO:K07827]
110836363  raf homolog serine/threonine-protein kinase phl [KO:K04365] [EC:2.7.11.1]
110829818  dual specificity mitogen-activated protein kinase kinase dSOR1 isoform X1 [KO:K04368] [EC:2.7.12.2]
110827503  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110838866  ribosomal protein S6 kinase 2 beta isoform X1 [KO:K04373] [EC:2.7.11.1]
110835233  insulin receptor substrate 2 isoform X1 [KO:K16172]
110831146  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
110834562  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
110828562  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
110831106  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
110834503  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
110839136  RAC serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110838212  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
110831173  target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
110826541  rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
110833926  proline-rich protein 5-like [KO:K20411]
110838820  ras-like GTP-binding protein Rho1 [KO:K04513]
110834942  ras-like GTP-binding protein Rho1 [KO:K04513]
110835611  protein kinase C, brain isozyme-like isoform X1 [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
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KO pathway
ko04150   
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