KEGG   PATHWAY: pau00230
Entry
pau00230                    Pathway                                
Name
Purine metabolism - Pseudomonas aeruginosa UCBPP-PA14
Class
Metabolism; Nucleotide metabolism
Pathway map
pau00230  Purine metabolism
pau00230

Module
pau_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:pau00230]
pau_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:pau00230]
pau_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:pau00230]
pau_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:pau00230]
pau_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:pau00230]
pau_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:pau00230]
pau_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:pau00230]
Other DBs
GO: 0006163 0042278
Organism
Pseudomonas aeruginosa UCBPP-PA14 [GN:pau]
Gene
PA14_65710  aspP; adenosine diphosphate sugar pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
PA14_68380  nudE; putative DP compound hydrolase [KO:K08312] [EC:3.6.1.-]
PA14_70270  algC; phosphomannomutase AlgC [KO:K15778] [EC:5.4.2.8 5.4.2.2]
PA14_61770  prs; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
PA14_23920  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
PA14_64220  purD; phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
PA14_52050  purN; phosphoribosylaminoimidazole synthetase [KO:K11175] [EC:2.1.2.2]
PA14_15890  purT; phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
PA14_15740  purL; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
PA14_52040  purM; phosphoribosylaminoimidazole synthetase [KO:K01933] [EC:6.3.3.1]
PA14_71600  purK; phosphoribosylaminoimidazole carboxylase [KO:K01589] [EC:6.3.4.18]
PA14_71620  purE; phosphoribosylaminoimidazole carboxylase, catalytic subunit [KO:K01588] [EC:5.4.99.18]
PA14_51240  purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
PA14_30110  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
PA14_18830  putative lyase [KO:K01756] [EC:4.3.2.2]
PA14_18850  putative lyase [KO:K01756] [EC:4.3.2.2]
PA14_64200  purH; phosphoribosylaminoimidazolecarboxamide transferase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
PA14_44500  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
PA14_17450  surE; putative stationary-phase survival protein SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
PA14_68390  putative hydrolase [KO:K20881] [EC:3.1.3.-]
PA14_44140  yaiE; conserved hypothetical protein [KO:K09913] [EC:2.4.2.1 2.4.2.2]
PA14_45440  conserved hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
PA14_60200  conserved hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
PA14_61460  hpt; putative hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
PA14_15310  guaB; inosine-5-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
PA14_14820  ndk; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
PA14_05050  putative Ham1 protein [KO:K01519] [EC:3.6.1.66]
PA14_69940  xpt; xanthine phosphoribosyltransferase [KO:K03816] [EC:2.4.2.22]
PA14_44710  xdhA; xanthine dehydrogenase [KO:K13481] [EC:1.17.1.4]
PA14_44740  xdhB; xanthine dehydrogenase [KO:K13482] [EC:1.17.1.4]
PA14_39520  putative hydroxylase large subunit [KO:K11177] [EC:1.17.1.4]
PA14_39530  putative hydroxylase molybdopterin-containing subunit [KO:K11178] [EC:1.17.1.4]
PA14_39540  putative ferredoxin [KO:K13483]
PA14_15340  guaA; GMP synthase [KO:K01951] [EC:6.3.5.2]
PA14_44770  gda1; probable guanine deaminase [KO:K01487] [EC:3.5.4.3]
PA14_01660  guaD; putative guanine deaminase [KO:K01487] [EC:3.5.4.3]
PA14_32340  putative deaminase [KO:K01487] [EC:3.5.4.3]
PA14_70440  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
PA14_72540  putative ribonucleotide reductase [KO:K00525] [EC:1.17.4.1]
PA14_49460  nrdA; ribonucleoside reductase, large chain [KO:K00525] [EC:1.17.4.1]
PA14_49470  nrdB; ribonucleoside reductase, small chain [KO:K00526] [EC:1.17.4.1]
PA14_39690  nrdD; putative ribonucleotide reductase [KO:K21636] [EC:1.1.98.6]
PA14_49840  dgt; deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
PA14_24730  putative deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
PA14_70470  spoT; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
PA14_69220  ppx; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
PA14_52180  relA; GTP pyrophosphokinase [KO:K00951] [EC:2.7.6.5]
PA14_22620  cyaB; CyaB [KO:K01768] [EC:4.6.1.1]
PA14_69610  cyaA; adenylate cyclase [KO:K05851] [EC:4.6.1.1]
PA14_65230  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
PA14_12490  AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
PA14_10730  putative decarboxylase family protein [KO:K06966] [EC:3.2.2.10 3.2.2.-]
PA14_01830  add; putative adenosine deaminase [KO:K21053] [EC:3.5.4.2]
PA14_16700  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
PA14_52160  mazG; conserved hypothetical protein [KO:K04765] [EC:3.6.1.9]
PA14_65690  icc; putative phosphohydrolases [KO:K03651] [EC:3.1.4.53]
PA14_07700  apaH; bis(5'-nucleosyl)-tetraphosphatase [KO:K01525] [EC:3.6.1.41]
PA14_57710  cysN; ATP sulfurylase GTP-binding subunit/APS kinase [KO:K00955] [EC:2.7.7.4 2.7.1.25]
PA14_57720  cysD; ATP sulfurylase small subunit [KO:K00957] [EC:2.7.7.4]
PA14_44820  putative transthyretin family protein [KO:K07127] [EC:3.5.2.17]
PA14_44840  conserved hypothetical protein [KO:K13485] [EC:4.1.1.97]
PA14_44830  putative polysaccharide deacetylase [KO:K16842] [EC:3.5.2.5]
PA14_44850  alc; allantoicase [KO:K01477] [EC:3.5.3.4]
PA14_49650  ylbA; conserved hypothetical protein [KO:K14977] [EC:3.5.3.26]
PA14_44860  allA; ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
PA14_64390  ureC; urease alpha subunit [KO:K01428] [EC:3.5.1.5]
PA14_64370  ureB; urease beta subunit [KO:K01429] [EC:3.5.1.5]
PA14_64350  ureA; urease gamma subunit [KO:K01430] [EC:3.5.1.5]
PA14_68350  arcC; carbamate kinase [KO:K00926] [EC:2.7.2.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
pau00030  Pentose phosphate pathway
pau00220  Arginine biosynthesis
pau00250  Alanine, aspartate and glutamate metabolism
pau00260  Glycine, serine and threonine metabolism
pau00340  Histidine metabolism
pau00630  Glyoxylate and dicarboxylate metabolism
pau00730  Thiamine metabolism
pau00740  Riboflavin metabolism
pau00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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