Physeter catodon (sperm whale): 102992191
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Entry
102992191 CDS
T06011
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
KO
K04368
mitogen-activated protein kinase kinase 1 [EC:
2.7.12.2
]
Organism
pcad
Physeter catodon (sperm whale)
Pathway
pcad01521
EGFR tyrosine kinase inhibitor resistance
pcad01522
Endocrine resistance
pcad04010
MAPK signaling pathway
pcad04012
ErbB signaling pathway
pcad04014
Ras signaling pathway
pcad04015
Rap1 signaling pathway
pcad04022
cGMP-PKG signaling pathway
pcad04024
cAMP signaling pathway
pcad04062
Chemokine signaling pathway
pcad04066
HIF-1 signaling pathway
pcad04068
FoxO signaling pathway
pcad04071
Sphingolipid signaling pathway
pcad04072
Phospholipase D signaling pathway
pcad04114
Oocyte meiosis
pcad04140
Autophagy - animal
pcad04148
Efferocytosis
pcad04150
mTOR signaling pathway
pcad04151
PI3K-Akt signaling pathway
pcad04210
Apoptosis
pcad04218
Cellular senescence
pcad04270
Vascular smooth muscle contraction
pcad04370
VEGF signaling pathway
pcad04371
Apelin signaling pathway
pcad04380
Osteoclast differentiation
pcad04510
Focal adhesion
pcad04540
Gap junction
pcad04550
Signaling pathways regulating pluripotency of stem cells
pcad04613
Neutrophil extracellular trap formation
pcad04620
Toll-like receptor signaling pathway
pcad04650
Natural killer cell mediated cytotoxicity
pcad04660
T cell receptor signaling pathway
pcad04662
B cell receptor signaling pathway
pcad04664
Fc epsilon RI signaling pathway
pcad04666
Fc gamma R-mediated phagocytosis
pcad04668
TNF signaling pathway
pcad04720
Long-term potentiation
pcad04722
Neurotrophin signaling pathway
pcad04725
Cholinergic synapse
pcad04726
Serotonergic synapse
pcad04730
Long-term depression
pcad04810
Regulation of actin cytoskeleton
pcad04910
Insulin signaling pathway
pcad04912
GnRH signaling pathway
pcad04914
Progesterone-mediated oocyte maturation
pcad04915
Estrogen signaling pathway
pcad04916
Melanogenesis
pcad04917
Prolactin signaling pathway
pcad04919
Thyroid hormone signaling pathway
pcad04921
Oxytocin signaling pathway
pcad04926
Relaxin signaling pathway
pcad04928
Parathyroid hormone synthesis, secretion and action
pcad04929
GnRH secretion
pcad04934
Cushing syndrome
pcad04935
Growth hormone synthesis, secretion and action
pcad05010
Alzheimer disease
pcad05022
Pathways of neurodegeneration - multiple diseases
pcad05034
Alcoholism
pcad05132
Salmonella infection
pcad05135
Yersinia infection
pcad05160
Hepatitis C
pcad05161
Hepatitis B
pcad05163
Human cytomegalovirus infection
pcad05164
Influenza A
pcad05165
Human papillomavirus infection
pcad05166
Human T-cell leukemia virus 1 infection
pcad05167
Kaposi sarcoma-associated herpesvirus infection
pcad05170
Human immunodeficiency virus 1 infection
pcad05200
Pathways in cancer
pcad05205
Proteoglycans in cancer
pcad05206
MicroRNAs in cancer
pcad05207
Chemical carcinogenesis - receptor activation
pcad05208
Chemical carcinogenesis - reactive oxygen species
pcad05210
Colorectal cancer
pcad05211
Renal cell carcinoma
pcad05212
Pancreatic cancer
pcad05213
Endometrial cancer
pcad05214
Glioma
pcad05215
Prostate cancer
pcad05216
Thyroid cancer
pcad05218
Melanoma
pcad05219
Bladder cancer
pcad05220
Chronic myeloid leukemia
pcad05221
Acute myeloid leukemia
pcad05223
Non-small cell lung cancer
pcad05224
Breast cancer
pcad05225
Hepatocellular carcinoma
pcad05226
Gastric cancer
pcad05230
Central carbon metabolism in cancer
pcad05231
Choline metabolism in cancer
pcad05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
pcad00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
102992191 (MAP2K1)
04012 ErbB signaling pathway
102992191 (MAP2K1)
04014 Ras signaling pathway
102992191 (MAP2K1)
04015 Rap1 signaling pathway
102992191 (MAP2K1)
04370 VEGF signaling pathway
102992191 (MAP2K1)
04371 Apelin signaling pathway
102992191 (MAP2K1)
04668 TNF signaling pathway
102992191 (MAP2K1)
04066 HIF-1 signaling pathway
102992191 (MAP2K1)
04068 FoxO signaling pathway
102992191 (MAP2K1)
04072 Phospholipase D signaling pathway
102992191 (MAP2K1)
04071 Sphingolipid signaling pathway
102992191 (MAP2K1)
04024 cAMP signaling pathway
102992191 (MAP2K1)
04022 cGMP-PKG signaling pathway
102992191 (MAP2K1)
04151 PI3K-Akt signaling pathway
102992191 (MAP2K1)
04150 mTOR signaling pathway
102992191 (MAP2K1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
102992191 (MAP2K1)
04148 Efferocytosis
102992191 (MAP2K1)
09143 Cell growth and death
04114 Oocyte meiosis
102992191 (MAP2K1)
04210 Apoptosis
102992191 (MAP2K1)
04218 Cellular senescence
102992191 (MAP2K1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
102992191 (MAP2K1)
04540 Gap junction
102992191 (MAP2K1)
04550 Signaling pathways regulating pluripotency of stem cells
102992191 (MAP2K1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
102992191 (MAP2K1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
102992191 (MAP2K1)
04620 Toll-like receptor signaling pathway
102992191 (MAP2K1)
04650 Natural killer cell mediated cytotoxicity
102992191 (MAP2K1)
04660 T cell receptor signaling pathway
102992191 (MAP2K1)
04662 B cell receptor signaling pathway
102992191 (MAP2K1)
04664 Fc epsilon RI signaling pathway
102992191 (MAP2K1)
04666 Fc gamma R-mediated phagocytosis
102992191 (MAP2K1)
04062 Chemokine signaling pathway
102992191 (MAP2K1)
09152 Endocrine system
04910 Insulin signaling pathway
102992191 (MAP2K1)
04929 GnRH secretion
102992191 (MAP2K1)
04912 GnRH signaling pathway
102992191 (MAP2K1)
04915 Estrogen signaling pathway
102992191 (MAP2K1)
04914 Progesterone-mediated oocyte maturation
102992191 (MAP2K1)
04917 Prolactin signaling pathway
102992191 (MAP2K1)
04921 Oxytocin signaling pathway
102992191 (MAP2K1)
04926 Relaxin signaling pathway
102992191 (MAP2K1)
04935 Growth hormone synthesis, secretion and action
102992191 (MAP2K1)
04919 Thyroid hormone signaling pathway
102992191 (MAP2K1)
04928 Parathyroid hormone synthesis, secretion and action
102992191 (MAP2K1)
04916 Melanogenesis
102992191 (MAP2K1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
102992191 (MAP2K1)
09156 Nervous system
04725 Cholinergic synapse
102992191 (MAP2K1)
04726 Serotonergic synapse
102992191 (MAP2K1)
04720 Long-term potentiation
102992191 (MAP2K1)
04730 Long-term depression
102992191 (MAP2K1)
04722 Neurotrophin signaling pathway
102992191 (MAP2K1)
09158 Development and regeneration
04380 Osteoclast differentiation
102992191 (MAP2K1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
102992191 (MAP2K1)
05206 MicroRNAs in cancer
102992191 (MAP2K1)
05205 Proteoglycans in cancer
102992191 (MAP2K1)
05207 Chemical carcinogenesis - receptor activation
102992191 (MAP2K1)
05208 Chemical carcinogenesis - reactive oxygen species
102992191 (MAP2K1)
05230 Central carbon metabolism in cancer
102992191 (MAP2K1)
05231 Choline metabolism in cancer
102992191 (MAP2K1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
102992191 (MAP2K1)
09162 Cancer: specific types
05210 Colorectal cancer
102992191 (MAP2K1)
05212 Pancreatic cancer
102992191 (MAP2K1)
05225 Hepatocellular carcinoma
102992191 (MAP2K1)
05226 Gastric cancer
102992191 (MAP2K1)
05214 Glioma
102992191 (MAP2K1)
05216 Thyroid cancer
102992191 (MAP2K1)
05221 Acute myeloid leukemia
102992191 (MAP2K1)
05220 Chronic myeloid leukemia
102992191 (MAP2K1)
05218 Melanoma
102992191 (MAP2K1)
05211 Renal cell carcinoma
102992191 (MAP2K1)
05219 Bladder cancer
102992191 (MAP2K1)
05215 Prostate cancer
102992191 (MAP2K1)
05213 Endometrial cancer
102992191 (MAP2K1)
05224 Breast cancer
102992191 (MAP2K1)
05223 Non-small cell lung cancer
102992191 (MAP2K1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
102992191 (MAP2K1)
05170 Human immunodeficiency virus 1 infection
102992191 (MAP2K1)
05161 Hepatitis B
102992191 (MAP2K1)
05160 Hepatitis C
102992191 (MAP2K1)
05164 Influenza A
102992191 (MAP2K1)
05163 Human cytomegalovirus infection
102992191 (MAP2K1)
05167 Kaposi sarcoma-associated herpesvirus infection
102992191 (MAP2K1)
05165 Human papillomavirus infection
102992191 (MAP2K1)
09171 Infectious disease: bacterial
05132 Salmonella infection
102992191 (MAP2K1)
05135 Yersinia infection
102992191 (MAP2K1)
09164 Neurodegenerative disease
05010 Alzheimer disease
102992191 (MAP2K1)
05022 Pathways of neurodegeneration - multiple diseases
102992191 (MAP2K1)
09165 Substance dependence
05034 Alcoholism
102992191 (MAP2K1)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
102992191 (MAP2K1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
102992191 (MAP2K1)
01522 Endocrine resistance
102992191 (MAP2K1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
pcad01001
]
102992191 (MAP2K1)
Enzymes [BR:
pcad01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
102992191 (MAP2K1)
Protein kinases [BR:
pcad01001
]
Serine/threonine kinases: STE group
STE7 family
102992191 (MAP2K1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Seadorna_VP7
Haspin_kinase
Motif
Other DBs
NCBI-GeneID:
102992191
NCBI-ProteinID:
XP_007127906
Ensembl:
ENSPCTG00005017538
UniProt:
A0A2Y9FRV8
LinkDB
All DBs
Position
11:58978893..59061940
Genome browser
AA seq
393 aa
AA seq
DB search
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGI
NT seq
1182 nt
NT seq
+upstream
nt +downstream
nt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcaaaagaagctggaggagctg
gagctcgatgaacagcagcggaagcgccttgaagccttccttacccagaagcagaaggtg
ggagaactgaaggatgacgactttgagaagatcagtgagctgggtgctggcaatggaggt
gtggtgttcaaggtctcccacaagccgtccggtctggttatggccagaaagctaattcac
ctggagatcaaacctgcaatccggaaccagatcatacgggagctgcaggttctccatgag
tgcaactccccttacattgtgggcttctacggtgcattctacagtgatggcgagatcagt
atctgcatggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaagggctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccttccaacatcctagtgaactcc
cgtggggagatcaagctctgtgactttggggtcagtgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tcggtgcagtcggacatctggagcatggggctctctctggttgagatggcggtcgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagacaccaccccggccgaggactcccggaaggcccctcagctcttat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaatgag
cctcctccaaagttgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacacccacccacgcggctggcatctaa
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