Puma concolor (puma): 112850049 Help Entry 112850049         CDS       T08890                                  Symbol TGFBR2 Name (RefSeq) TGF-beta receptor type-2   KO K04388   TGF-beta receptor type-2 [EC:2.7.11.30] Organism pcoo  Puma concolor (puma) Pathway pcoo04010   MAPK signaling pathway pcoo04060   Cytokine-cytokine receptor interaction pcoo04068   FoxO signaling pathway pcoo04144   Endocytosis pcoo04218   Cellular senescence pcoo04350   TGF-beta signaling pathway pcoo04380   Osteoclast differentiation pcoo04390   Hippo signaling pathway pcoo04520   Adherens junction pcoo04659   Th17 cell differentiation pcoo04926   Relaxin signaling pathway pcoo04933   AGE-RAGE signaling pathway in diabetic complications pcoo05142   Chagas disease pcoo05161   Hepatitis B pcoo05166   Human T-cell leukemia virus 1 infection pcoo05200   Pathways in cancer pcoo05202   Transcriptional misregulation in cancer pcoo05210   Colorectal cancer pcoo05212   Pancreatic cancer pcoo05220   Chronic myeloid leukemia pcoo05225   Hepatocellular carcinoma pcoo05226   Gastric cancer pcoo05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:pcoo00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     112850049 (TGFBR2)    04350 TGF-beta signaling pathway     112850049 (TGFBR2)    04390 Hippo signaling pathway     112850049 (TGFBR2)    04068 FoxO signaling pathway     112850049 (TGFBR2)   09133 Signaling molecules and interaction    04060 Cytokine-cytokine receptor interaction     112850049 (TGFBR2)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     112850049 (TGFBR2)   09143 Cell growth and death    04218 Cellular senescence     112850049 (TGFBR2)   09144 Cellular community - eukaryotes    04520 Adherens junction     112850049 (TGFBR2)  09150 Organismal Systems   09151 Immune system    04659 Th17 cell differentiation     112850049 (TGFBR2)   09152 Endocrine system    04926 Relaxin signaling pathway     112850049 (TGFBR2)   09158 Development and regeneration    04380 Osteoclast differentiation     112850049 (TGFBR2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     112850049 (TGFBR2)    05202 Transcriptional misregulation in cancer     112850049 (TGFBR2)   09162 Cancer: specific types    05210 Colorectal cancer     112850049 (TGFBR2)    05212 Pancreatic cancer     112850049 (TGFBR2)    05225 Hepatocellular carcinoma     112850049 (TGFBR2)    05226 Gastric cancer     112850049 (TGFBR2)    05220 Chronic myeloid leukemia     112850049 (TGFBR2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     112850049 (TGFBR2)    05161 Hepatitis B     112850049 (TGFBR2)   09174 Infectious disease: parasitic    05142 Chagas disease     112850049 (TGFBR2)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     112850049 (TGFBR2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     112850049 (TGFBR2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pcoo01001]     112850049 (TGFBR2) Enzymes [BR:pcoo01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.30  receptor protein serine/threonine kinase      112850049 (TGFBR2) Protein kinases [BR:pcoo01001]  Receptor serine/threonine kinases (RSTK): TKL group   TGFBR2 family [OT]    112850049 (TGFBR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  ecTbetaR2 PK_Tyr_Ser-Thr Pkinase ABC1 Haspin_kinase Pkinase_fungal Motif Other DBs NCBI-GeneID:  112850049 NCBI-ProteinID:  XP_025769433 UniProt:  A0A6P6H1K5 LinkDB All DBs Position Unknown AA seq 651 aa AA seqDB search MAAVCQMVASVSDSEMPTAIKNLLSENKSFNSGPICLPPQHVNQRHQQNLGTVSVSTCNA QFNEYLARLQGPALQSNINPGVAVEVRRLTAVSCLTYSVSSELANTLLYRTTLLHFNNGM MVTDNNGIIKFPQLCKFCDVRSSTCDSQKSCLSNCSITSICERPHEVCLAVWRKNDENIT LETLCHDPKVTYHGIALEDSASPKCIMKEKKVLGETFFMCSCSTDECNDYIIFSEEYATN NPDLLLVIFQVTGVSLLPPLGIAIAVIIIFYCYRVHRQQKLSPSWDTSKPRKLMEFSEHL AIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAV KIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEY LTRHVISWEDLRTLGSSLARGIAHLHSDHTLCGRPKMPIVHRDLKSSNILVKNDLTCCLC DFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWE MTSRCNAVGEVKEYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSSWLNHQGIQMVCET LTECWDHDPEARLTAQCVAERFSELQHLDRLSGRSCSEEKIPEDGSLNTTK NT seq 1956 nt NT seq  +upstreamnt  +downstreamnt atggcggctgtctgccagatggtcgcctcagtgtctgactccgaaatgccaactgcaatt aaaaaccttctttcagagaacaagtctttcaattctgggcccatatgccttcctcctcaa catgtgaaccagcggcatcagcagaatctgggaacggtctccgtttctacctgtaatgct cagtttaatgagtacttggctaggttacagggcccagctcttcaatcaaacattaacccg ggtgttgctgtggaggtgaggagactgacggcagtgtcctgcctcacctacagtgtctcc tctgagttggccaacacgcttttgtaccgcacaactctgctccattttaacaatggcatg atggtcaccgacaacaatggtatcatcaagtttccgcaattgtgcaaattttgtgatgtg agatcttccacctgtgacagccagaaatcctgcctgagcaactgcagcatcacgtctatc tgcgagaggccacacgaagtctgtctggccgtctggagaaagaacgatgagaacataacc ctagagacgctttgccatgaccccaaggttacctaccatggaattgctcttgaagactct gcttctcccaagtgtattatgaaggaaaaaaaggtgttgggcgagactttctttatgtgt tcctgtagcaccgatgaatgcaatgactacatcatcttctcagaagaatacgccaccaac aaccctgacctgttgttagtcatattccaagtgacaggcgtcagcctcctgccccccctg gggatcgccatagccgtcatcatcatcttctactgctaccgtgttcaccggcagcagaag ctgagcccatcctgggataccagcaagccacgaaagctcatggagttcagcgagcacctt gccatcattctggaagacgaccgctctgacatcagctctacctgcgccaacaacatcaac cacaacacagagctgctgcccattgagctggacaccctggtggggaaaggccgcttcgcc gaggtctacaaggccaagctgaagcagaacacttctgaacagttcgagaccgtggcggtc aagatcttcccttacgaggagtacgcctcctggaagacggagaaggacattttctcagac atcaacctgaagcacgagaacatactgcagttcctgacagccgaggagcgcaagacggag ctggggaagcagtactggctgatcacggccttccacgccaagggcaacctgcaggagtac ctgacgcggcacgtcatcagctgggaggacctgcgcacgctgggcagctccctcgcccgg ggcattgcccacctgcacagcgaccacaccctgtgcgggaggcccaagatgcccatcgtg cacagggacctcaagagctccaatatcctcgtcaagaatgatctgacctgctgcctgtgt gactttgggctttccctgcgtctggacccgaccctgtctgtggatgacctggccaacagc gggcaggtgggaactgcaagatacatggctccagaagtcctagagtccaggatgaatttg gagaatgttgagtcctttaagcagacggacgtctactccatggctctggtcctctgggaa atgacatctcgctgtaatgcggtgggagaggtgaaagagtacgagcctccatttggttcc aaggtgcgggagcatccctgtgttgagagcatgaaggacaatgtgctgagagaccgagga cgaccagaaattcccagctcctggctcaaccaccagggcatccagatggtgtgcgagact ctgaccgagtgctgggaccatgacccggaggcccggctcacggcccagtgcgtggcagag cgcttcagtgaactgcagcacctggacaggctctcggggaggagctgctccgaggagaag attcccgaagatggctcgttgaacactaccaaatag

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