Puma concolor (puma): 112852904 Help Entry 112852904         CDS       T08890                                  Symbol INSR Name (RefSeq) insulin receptor   KO K04527   insulin receptor [EC:2.7.10.1] Organism pcoo  Puma concolor (puma) Pathway pcoo04010   MAPK signaling pathway pcoo04014   Ras signaling pathway pcoo04015   Rap1 signaling pathway pcoo04022   cGMP-PKG signaling pathway pcoo04066   HIF-1 signaling pathway pcoo04068   FoxO signaling pathway pcoo04072   Phospholipase D signaling pathway pcoo04150   mTOR signaling pathway pcoo04151   PI3K-Akt signaling pathway pcoo04152   AMPK signaling pathway pcoo04211   Longevity regulating pathway pcoo04213   Longevity regulating pathway - multiple species pcoo04520   Adherens junction pcoo04910   Insulin signaling pathway pcoo04913   Ovarian steroidogenesis pcoo04923   Regulation of lipolysis in adipocytes pcoo04930   Type II diabetes mellitus pcoo04931   Insulin resistance pcoo04932   Non-alcoholic fatty liver disease pcoo04960   Aldosterone-regulated sodium reabsorption pcoo05010   Alzheimer disease pcoo05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:pcoo00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     112852904 (INSR)    04014 Ras signaling pathway     112852904 (INSR)    04015 Rap1 signaling pathway     112852904 (INSR)    04066 HIF-1 signaling pathway     112852904 (INSR)    04068 FoxO signaling pathway     112852904 (INSR)    04072 Phospholipase D signaling pathway     112852904 (INSR)    04022 cGMP-PKG signaling pathway     112852904 (INSR)    04151 PI3K-Akt signaling pathway     112852904 (INSR)    04152 AMPK signaling pathway     112852904 (INSR)    04150 mTOR signaling pathway     112852904 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     112852904 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     112852904 (INSR)    04923 Regulation of lipolysis in adipocytes     112852904 (INSR)    04913 Ovarian steroidogenesis     112852904 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     112852904 (INSR)   09149 Aging    04211 Longevity regulating pathway     112852904 (INSR)    04213 Longevity regulating pathway - multiple species     112852904 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     112852904 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     112852904 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     112852904 (INSR)    04932 Non-alcoholic fatty liver disease     112852904 (INSR)    04931 Insulin resistance     112852904 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pcoo01001]     112852904 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:pcoo04090]     112852904 (INSR) Enzymes [BR:pcoo01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      112852904 (INSR) Protein kinases [BR:pcoo01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    112852904 (INSR) CD molecules [BR:pcoo04090]  Proteins   112852904 (INSR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like B2 DUF4476 Motif Other DBs NCBI-GeneID:  112852904 NCBI-ProteinID:  XP_025772224 UniProt:  A0A6P6H936 LinkDB All DBs Position Unknown AA seq 1456 aa AA seqDB search MANSALNHSWPALSKRWLKRWAFKRENKCINHGPPKALSGTQILMKFHPLLASPPSPSSC PGTLRLIHRLAGSEPKPCVRPFDSEAAAAAAGSSGGPWRPGRPDFPTMEDEQAGCTRVAL RALARGATGPWTPRNVKLPGHSRRGPPVETLTHPLPVCPGMDIRNNLTRLHELANCSVIE GHLQILLMFKTRPEDFRDLSFPKLVMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFN YALVIFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD DNEECGDICPGTAKGKTNCPATVINGQFVERCWTHGHCQKVCPTICKSHGCTADGLCCHS ECLGNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCRDLHNKCKNSR RQGCHQYVIHNNRCIPECPSGYTMNSSNLMCTPCLGPCPKVCHILEGEKTIDSVTSAQEL RGCTVVNGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRG ETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKG RQERNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWEPYWPPDFRDLLGFMLFYKEA PYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLV TFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLV FWERQAEDSELYELDYCLKGLKLPSRTWSPPFESEGSQKHNQSEYEESAGECCSCPKTDS QILKELEESSFRKTFEDYLHNVVFVPRPSRKRRALADAGNVTAAVPTVPGFPNTSSSVPT SPEEHKPFEKVVNKESLVISGLRHFTGYRIELQACNQDAPEERCSVAAYVSARTMPEDFY VIGFFALYQELHLCVSRRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSWTEATYFYVT DYYVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVF PCSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKTVNESASLR ERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMVHGDLKSYLRSLRPEAENNP GRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYE TDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVL KFVMDGGYLDQPDNCPERVTDLMHMCWQFNPKMRPTFLEIVDLLKDDLHPSFPEVSFFHS EENKAPESEELEMEFEDMESVPLDRASHSQREEAGGRDGVSSLGLKRNYEDHIPYTHMNG GKKNGRILTLPRSNPS NT seq 4371 nt NT seq  +upstreamnt  +downstreamnt atggctaactcagcgctcaaccactcctggccagccctctccaagcggtggctgaagcgg tgggccttcaagagagagaacaagtgcatcaaccatggacccccgaaggccctgtctggg acccagatccttatgaagttccacccgctcctggcctctccgcccagcccatcttcctgc ccaggcacattgagactgattcacaggctggcaggttctgagcccaagccatgtgtccgg ccctttgactctgaagcagcagcagcagcggccgggagcagcggcggcccctggaggcct gggcgcccagactttcccaccatggaggatgagcaggcaggctgcacacgtgtggctctg cgggcgctcgcacggggcgcaacaggcccgtggacccctagaaacgtgaagctgccggga cacagccggagagggccacccgtggagacactcacacacccgttgccagtctgccctggc atggatatccggaacaacctgacgaggctgcacgaactggccaactgctcggtcattgaa ggtcatttgcagatactgctcatgttcaaaacgaggcccgaggacttccgagacctcagt ttccccaaactcgtcatgatcactgattacctgctgctcttccgggtgtacgggctggag agcctgaaggacctcttccccaacctcacggtcatccggggctcgcgcctcttcttcaac tacgcgctggtcatcttcgagatggtgcacctgaaggagcttggcctctacagcttgatg aacattacccggggctccgtccgcatcgagaagaataatgagctgtgctacctggccacc atcgactggtcgcgcatcctggattcggtggaggataattacattgtgttgaacaaagac gacaacgaggagtgtggggacatttgtccaggcactgcaaagggcaagaccaactgccct gccactgtcatcaacgggcagtttgtggagcgttgttggacacacggccattgccagaaa gtttgtccgaccatctgcaagtcgcacggctgcacggccgacggcctctgctgccacagc gagtgtttgggcaactgctccgagcccgacgaccccaccaagtgcgtggcctgtcgcaac ttctacctggacggcaggtgcgtggagacctgcccgcccccctactaccacttccaagac tggcgctgcgtgaacttcagcttctgccgggacctgcacaataaatgcaagaactcccgg agacagggttgccaccagtatgtcattcacaacaacaggtgcatccctgagtgcccctcg gggtacacgatgaattccagcaacctgatgtgtactccctgcctgggcccctgtcccaag gtctgccacatcctggaaggcgagaagaccatcgactcggtgacatctgcccaggagctc cgaggctgcaccgtcgtcaacggaagcctaatcatcaacattcgagggggcaacaacctg gcagctgagctggaggccaacctcggactcattgaagaaatttccgggtatctgaagatc cggagatcctatgctcttgtgtcactttcctttttccggaagttacggctgattcgggga gagaccttggaaatcgggaactactctttctatgccttggacaaccagaacctgaggcag ctatgggactggagcaaacacaacctcaccatcactcaggggaaactcttcttccactat aatcccaaactctgcttgtcggaaattcacaagatggaggaggtttcaggaaccaagggg cgccaggagcggaacgacattgccctgaagaccaatggggaccaggcgtcttgtgaaaac gaactacttaaattttcttacattcggacatcttacgacaagatcttgctgaaatgggag ccgtactggccgcctgacttccgagacctccttggcttcatgctcttctacaaagaggcc ccttatcagaatgtgaccgagttcgacgggcaggacgcgtgtggctccaacagctggacg gtggtggacattgacccgcctctgaggtccaatgaccccaagtcgcagaaccacccaggg tggctgatgcggggtctcaagccctggacccagtatgccatctttgtcaagaccttggtc accttttctgatgagcgccgcacgtatggggccaagagtgacatcatctatgtccagacc gatgccaccaacccttccgtccccctggatcctatctcggtttcgaattcctcctctcag atcattctgaagtggaagcctccctcggaccccaatggcaacatcacgcactacctggtg ttctgggagaggcaggcggaggacagcgagctgtatgagttggattattgcctcaaaggg ttgaagctgccttcccggacctggtccccgccgttcgagtccgagggctcccagaagcac aatcagagtgagtacgaggagtccgctggcgaatgctgctcgtgtcccaaaaccgactct cagatcctgaaggagctggaggagtcctctttcaggaagacgttcgaggattacctgcac aatgtggttttcgtgcccaggccgtcgcggaagcgcagggccctcgccgacgctgggaac gtgacggccgccgtgcccacggtgcctggtttccccaacacttccagcagcgtgcccacg agcccggaagagcacaagcccttcgagaaggtggtgaacaaagagtcgctggtcatctcc ggcctgcgtcacttcaccggctaccgcatcgagctgcaggcttgcaaccaagatgccccc gaggagaggtgcagcgtggctgcctacgtcagcgccaggaccatgcccgaagacttttac gtcattggcttctttgctctttatcaggagctgcacctctgtgtctcccgtagacacttt gctctggagcggggctgcaggctgcgagggctgccgccggggaattacagtgtgcgagtt cgggccacctccctggcgggcaacggctcctggacagaagccacttatttctatgtgaca gactattatgtcccatcgaacattgcaaaaattatcatcgggcctctcatctttgtcttt ctcttcagtgttgtgattggaagtatttatctattcctgagaaagaggcagccggatggc ccactggggccgctgtatgcttcttcaaaccctgagtacctcagtgccagtgatgtgttt ccctgctctgtgtatgtgccggacgagtgggaggtgcctcgggagaagatcactctcctg cgcgagctggggcagggctccttcggcatggtgtacgagggcaatgccagggacatcgtc aagggcgaggcggagacccgcgtcgcggtgaagacggtcaacgagtccgccagtctgcga gagaggatcgagtttctcaacgaggcctcagtcatgaagggcttcacctgtcatcacgtg gtccgcctcctgggggtggtgtccaaaggccagccgacgctggtggtgatggagctgatg gttcacggagacctgaagagctacctccgctccctgcggccggaggctgagaataaccct ggccgccctccccctactctgcaagagatgattcagatggcggcggagatcgccgacggg atggcgtacctgaatgccaagaagtttgtgcaccgggatctcgcagctcgaaattgcatg gtggcccacgacttcaccgtcaaaattggagacttcggaatgaccagagacatctatgaa acggattactaccggaaaggaggcaagggtctgctccccgtgcggtggatggcaccggaa tccctgaaggacggggtcttcaccacttcttctgacatgtggtcctttggtgtggtcctt tgggaaatcaccagcttggcggaacaaccttaccaaggcctgtctaatgaacaggtgttg aaatttgtcatggacggaggatatttggaccaacctgataactgtccggagagagtcacc gacctgatgcacatgtgctggcagttcaatcccaagatgcggcccaccttcctggagatc gttgacctgctcaaggacgacctgcaccccagctttccggaagtttccttcttccacagc gaggagaacaaggcgcctgagagtgaggagttggaaatggagtttgaggacatggagagt gtccccctggatcgggcctcacactcacagagggaagaggccgggggccgggatggagtg tcctcgctgggcctcaagcggaactacgaggaccacatcccttacacccacatgaacggg ggcaagaaaaacggacggattctgaccctgccgaggtcgaatccttcctaa

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