Puma concolor (puma): 112871853 Help Entry 112871853         CDS       T08890                                  Symbol LCK Name (RefSeq) tyrosine-protein kinase Lck   KO K05856   lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2] Organism pcoo  Puma concolor (puma) Pathway pcoo04064   NF-kappa B signaling pathway pcoo04380   Osteoclast differentiation pcoo04650   Natural killer cell mediated cytotoxicity pcoo04658   Th1 and Th2 cell differentiation pcoo04659   Th17 cell differentiation pcoo04660   T cell receptor signaling pathway pcoo05135   Yersinia infection pcoo05166   Human T-cell leukemia virus 1 infection pcoo05235   PD-L1 expression and PD-1 checkpoint pathway in cancer pcoo05340   Primary immunodeficiency Brite KEGG Orthology (KO) [BR:pcoo00001]  09130 Environmental Information Processing   09132 Signal transduction    04064 NF-kappa B signaling pathway     112871853 (LCK)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     112871853 (LCK)    04660 T cell receptor signaling pathway     112871853 (LCK)    04658 Th1 and Th2 cell differentiation     112871853 (LCK)    04659 Th17 cell differentiation     112871853 (LCK)   09158 Development and regeneration    04380 Osteoclast differentiation     112871853 (LCK)  09160 Human Diseases   09161 Cancer: overview    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     112871853 (LCK)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     112871853 (LCK)   09171 Infectious disease: bacterial    05135 Yersinia infection     112871853 (LCK)   09163 Immune disease    05340 Primary immunodeficiency     112871853 (LCK)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pcoo01001]     112871853 (LCK)   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:pcoo03036]     112871853 (LCK) Enzymes [BR:pcoo01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      112871853 (LCK) Protein kinases [BR:pcoo01001]  Non-receptor tyrosine kinases   SRC family    112871853 (LCK) Chromosome and associated proteins [BR:pcoo03036]  Eukaryotic type   Centrosome formation proteins    Kinases and associated factors     112871853 (LCK) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase SH2 SH3_1 SH3_2 SH3_9 ABC1 Haspin_kinase SH3_16 SH3_3 Motif Other DBs NCBI-GeneID:  112871853 NCBI-ProteinID:  XP_025790713 UniProt:  A0A6P6IUY9 LinkDB All DBs Position Unknown AA seq 509 aa AA seqDB search MGCSCSSNPEDDWMENIDVCENCHYPIVPLDGKATLPMRNGSDVRDPLVTYEGSNPPASP LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH YKIRNLDKGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL VRLYAVVTQEPIYIITEYMENGSLVDFLKTPPGIKLTINKLLDMAAQIAEGMAFIEERNY IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKER PEERPTFDYLRSVLEDFFTATEGQYQAQP NT seq 1530 nt NT seq  +upstreamnt  +downstreamnt atgggctgtagctgcagctcaaaccctgaagatgactggatggaaaacatcgatgtgtgt gagaactgccattacccgatagtcccactggatggcaaggccacgctgcccatgcggaat ggctctgatgtgagggatccactagttacctacgaaggctccaatcccccagcctcacca ttgcaagacaacctggttatcgctctgcacagctatgagccctctcacgatggagacctg ggcttcgagaagggtgaacagctccgtatcctggagcagagcggcgagtggtggaaggcg cagtccctgaccacgggccaggaaggtttcatccccttcaacttcgtggccaaagcgaac agcctggagcccgaaccctggttcttcaagaacctgagccgcaaggacgcggaacggcag ctcctggcgcccgggaacacgcacggctccttcctgatccgggagagcgagagcaccgcg ggatcgttttcactgtccgtgcgggacttcgaccagaaccagggagaggtggtgaaacat tacaagatccgtaacctggacaaaggcggcttctacatctccccccgcatcacttttcct ggcctgcacgagctggtccgccattacaccaatgcttcggacgggctgtgcacgcggttg agtcgcccctgccagacccagaagccccagaagccttggtgggaggacgagtgggaggtt cccagggagacgctgaagctggtggagcggctgggggctggccagttcggggaggtgtgg atggggtactacaacgggcacacaaaggtggcagtgaagagtctgaagcagggcagcatg tcccccgacgccttcctggccgaggccaacctcatgaagcagctacaacaccagaggctg gtccggctctacgcggtggtcacccaggagcccatctacatcatcacggaatacatggag aatgggagcctggtggatttcctcaagacccctccgggcatcaagttgaccatcaacaaa ctcttggacatggcagcccaaattgcagagggcatggcattcattgaagaacggaattac atccaccgtgacctgagggctgccaacatcctggtgtcggacaccctgagctgcaagatt gcagactttggcctagcacgcctcattgaggacaatgagtacacagccagggagggggcc aagtttccaattaagtggacagcaccagaagccattaactacgggacattcaccatcaag tcggacgtgtggtcttttgggatcctactgacggagattgtcacccatggccgcatccct tacccagggatgaccaatcctgaggtgattcagaacctggagcgaggctaccgcatggtg cgacctgacaactgcccagaggagctataccacctcatgatgctgtgctggaaggagcgg ccagaggaacggcccacctttgactacctgcgcagcgtgctggaggacttcttcacggcc acagagggccagtaccaggcccagccctga

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