KEGG T08746: 105824322

Propithecus coquereli (Coquerel's sifaka): 105824322

Entry

105824322         CDS       T08746

Name

(RefSeq) steroid 17-alpha-hydroxylase/17,20 lyase

K00512

steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]

Organism

pcoq Propithecus coquereli (Coquerel's sifaka)

Pathway

pcoq00140

Steroid hormone biosynthesis

pcoq01100

Metabolic pathways

pcoq04913

Ovarian steroidogenesis

pcoq04917

Prolactin signaling pathway

pcoq04927

Cortisol synthesis and secretion

pcoq04934

Cushing syndrome

Module

pcoq_M00110

C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone

pcoq_M00976

C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone

pcoq_M00977

C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone

Brite

KEGG Orthology (KO) [BR:pcoq00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    105824322
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    105824322
   04917 Prolactin signaling pathway
    105824322
   04927 Cortisol synthesis and secretion
    105824322
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    105824322
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:pcoq00199]
    105824322
Enzymes [BR:pcoq01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.19  steroid 17alpha-monooxygenase
     105824322
    1.14.14.32  17alpha-hydroxyprogesterone deacetylase
     105824322
Cytochrome P450 [BR:pcoq00199]
Cytochrome P450, animal type
  CYP17 family
   105824322

SSDB

Motif

Pfam:

p450

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

Ensembl:

VGNC:

UniProt:

LinkDB

Position

Unknown

AA seq 508 aa
MWELVALLLLTLAYFFWPKVRCPGAKYPKSLPSLPLVGSLPFLPRHGHQHVNFFKLQKKY
GPIYSVRMGPKTLVIVGHYQLAKEVLVKKGKDFSGRPQVASLDILSDNQKGIAFADYGTH
WQLHRKLVQATFALFKDGNQKLGKIICQEVSVLCDMLVTHDGQSIDISLPVFLAITNIIC
LICFNNSYKYGDPELTVIQKYNEGILENLGNSSLVDTFPWLQIFPNKSLEMLRKCVRMRN
ELLKGIMEKYKEKFRSNSTTNMLDVMIQAKMNSDNNNSDPDQDSKKLSDKHILATVGDIF
GAGVETTASVVKWIVAFLLHNPQLKKKIHEEIDQNIGFSRTPTISDRSHLILLEATIREV
LRIRPVAPLLIPHKANNDSSIGEFAIDKGTEVVINLWALHHNEKEWHQPDQFMPERFLDS
TGTQLISPSLSYLPFGAGPRSCVGEVLARQELFLFMSWLLQRFELEVPDDGQLPSLEGNP
KMVFLIDPFKVKIKVRQAWREAQAEAST

NT seq 1527 nt +upstreamnt +downstreamnt
atgtgggaactcgtggctctcttgctgctcaccctagcctatttcttttggcccaaggta
aggtgccctggtgccaagtatcccaagagcctcccgtctctgcccctggtgggcagcctg
ccgttcctccccagacatggccatcaacatgtcaacttcttcaagctgcagaaaaaatac
ggccccatctattctgttcgtatgggtcccaagactctagtgattgtcggccactaccag
ctggccaaggaggtgcttgttaagaagggcaaggatttctctgggcggccccaagtggcc
tctctagacatcctgtcagacaaccaaaagggcatcgccttcgctgactacggcacccac
tggcagctgcatcggaagctggtgcaggccacttttgccctgttcaaagatggcaaccag
aagctagggaagatcatatgtcaggaagtcagtgtattatgtgatatgctggtcacccat
gacggacagtccatagatatttccttgcctgtcttcctggcaataaccaacataatctgc
ttgatctgcttcaacaactcctacaagtacggggaccccgagctgacagtgatacagaag
tataacgaaggcatcctggagaatctgggcaacagcagtctggtagacacattcccctgg
ctgcagattttccccaacaaaagcctggaaatgttgaggaagtgtgttaggatgcgaaat
gagctgctgaaaggaataatggaaaagtacaaggagaaattcaggagcaactctaccacc
aacatgctggacgttatgatccaagccaagatgaactcagataataacaacagtgaccca
gaccaggattcaaagaagctttcagataaacacattcttgccactgtaggggacatcttt
ggggccggtgtggagaccactgcctctgtggtaaagtggattgtggcctttctgctgcac
aatcctcagttgaagaagaagatccatgaggagattgaccagaatataggtttcagccgt
acaccaactatcagcgaccggagccatctcatcctgctggaggccaccatccgagaggtg
cttcgcatcaggcccgtggcccctctgctcatcccccacaaggctaacaatgactccagc
attggcgagtttgccattgacaagggcacagaggttgtcatcaatttgtgggcactgcat
cacaatgagaaggagtggcaccagccagaccagttcatgcctgagcgcttcttggattca
acggggacccagctcatctcaccatcgttgagctacttgcccttcggagcgggaccccgc
tcctgcgtaggtgaagtcctggcccgccaggagctcttcctcttcatgtcctggttgctg
cagaggttcgaactggaggtgccagatgatgggcagctgccctccctggaaggcaacccc
aagatggtctttctgatcgatcctttcaaagtgaagatcaaggtgcgccaggcctggagg
gaagcccaggctgaggctagcacctaa

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