Phascolarctos cinereus (koala): 110203364 Help Entry 110203364         CDS       T05867                                  Symbol INSR Name (RefSeq) insulin receptor isoform X1   KO K04527   insulin receptor [EC:2.7.10.1] Organism pcw  Phascolarctos cinereus (koala) Pathway pcw04010   MAPK signaling pathway pcw04014   Ras signaling pathway pcw04015   Rap1 signaling pathway pcw04022   cGMP-PKG signaling pathway pcw04066   HIF-1 signaling pathway pcw04068   FoxO signaling pathway pcw04072   Phospholipase D signaling pathway pcw04150   mTOR signaling pathway pcw04151   PI3K-Akt signaling pathway pcw04152   AMPK signaling pathway pcw04211   Longevity regulating pathway pcw04213   Longevity regulating pathway - multiple species pcw04520   Adherens junction pcw04910   Insulin signaling pathway pcw04913   Ovarian steroidogenesis pcw04923   Regulation of lipolysis in adipocytes pcw04930   Type II diabetes mellitus pcw04931   Insulin resistance pcw04932   Non-alcoholic fatty liver disease pcw04960   Aldosterone-regulated sodium reabsorption pcw05010   Alzheimer disease pcw05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:pcw00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     110203364 (INSR)    04014 Ras signaling pathway     110203364 (INSR)    04015 Rap1 signaling pathway     110203364 (INSR)    04066 HIF-1 signaling pathway     110203364 (INSR)    04068 FoxO signaling pathway     110203364 (INSR)    04072 Phospholipase D signaling pathway     110203364 (INSR)    04022 cGMP-PKG signaling pathway     110203364 (INSR)    04151 PI3K-Akt signaling pathway     110203364 (INSR)    04152 AMPK signaling pathway     110203364 (INSR)    04150 mTOR signaling pathway     110203364 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     110203364 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     110203364 (INSR)    04923 Regulation of lipolysis in adipocytes     110203364 (INSR)    04913 Ovarian steroidogenesis     110203364 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     110203364 (INSR)   09149 Aging    04211 Longevity regulating pathway     110203364 (INSR)    04213 Longevity regulating pathway - multiple species     110203364 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     110203364 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     110203364 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     110203364 (INSR)    04932 Non-alcoholic fatty liver disease     110203364 (INSR)    04931 Insulin resistance     110203364 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pcw01001]     110203364 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:pcw04090]     110203364 (INSR) Enzymes [BR:pcw01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      110203364 (INSR) Protein kinases [BR:pcw01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    110203364 (INSR) CD molecules [BR:pcw04090]  Proteins   110203364 (INSR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like B2 Motif Other DBs NCBI-GeneID:  110203364 NCBI-ProteinID:  XP_020835508 UniProt:  A0A6P5JQA2 LinkDB All DBs Position Unknown AA seq 1374 aa AA seqDB search MGAVRPLTVGLPPLLLLLLSTSCGLISGEVCPSMDIRNNLTQLNMLERCSVIEGNLQILL MFKTKPEDFRDLSFPRLTMITEYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFE MVHLKEIGLHSLMNITRGAVRIEKNNELCYLSTIDWSQILDSVEDNYIVDNKDDKEECGD VCPGAVKGVNSCKSTVINGQFIERCWTHNHCQKVCPPSCKWQGCTASGQCCHSECLGNCS EPNDPEKCVACRNFYLDGKCVETCPPDYYHFQDWRCVNFSVCQELHNKCKNSRKPSCPQY VIHNNRCIPECPSGYTMNSTNLHCSPCSGPCPKVCNIEADRTIDSVHAAQALRGCTVING SLVINIRGGNNIAAELEANLGLIEEITGYLKIRRSYALVSLSFFRKLHLIRGETLEIGNY SFYALDNQNLRQLWDWSKHNLTIAKGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIA LKTNGDQASCENELLRFSSIRTSHDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEF DGQDACGSNSWTVVDVEPPVRSNDPKTQNQHPGWLMRNLKPWTQYAIFVKTLVTFSDERR TYGAKSEIIYVQTNATVPSVPLDPISVSNSSSQIILKWKPPSEPNGNITHYLVYWEKQAE DLELYELDYCLKGLKLPSRTWSPPFESEDSQKHNQSNHEDPNGECCSCPKTDSQILKELE ESSFRKMFENYLHNEVFIPRKASSGNGADDSRPARRRRDLRVRMANMTVVTPTRSSLSNA SSTTAPASTEEPKPFEKVKSKESLVISGLQHFTGYRIELQACNHDEQESRCGLAAYVSAR TMPEAKADDIVGAVTHEVLENVVHLRWQEPKHPNGLIILYEVNYWRVGDTEELHLCVSRK HYAHEQGCRLRGLQPGNYTVRIRATSLAGNGSWTEHTYFYVADYLDVPSNIVKIVIGPVI IIIFLISTVAAVYVFVKKRQTEGPTGPLFASSNPEYLSASDVYVPDEWEVAREKISLLRE LGQGSFGMVYEGNAKDIVKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFSCHHVVR LLGVVSKGQPTLVVMELMVHGDLKSYLRSLRPDAENNPGRPPPTLREIIQMAVEIADGMA YLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESL KDGVFTTYSDVWSFGVVLWEISSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVNSL MQMCWQYNPKMRPTFIEIIEMLKDDLHPSFREVSFFYSEENKPPESEEFEMDFENMESIP LDPSSYSQRDEVLGRDNGPSLGLKGNYEERIPYTHMNGGKKNGRILSLPRSNPS NT seq 4125 nt NT seq  +upstreamnt  +downstreamnt atgggggccgtgcggccgctcactgtcgggttgcccccgctactgctactgctgctgagc acttcgtgtggcttgatctctggagaagtgtgcccgagtatggacattcggaataacctc acacaattgaacatgttggaacgctgctctgtcattgaaggcaacttgcagatactgctg atgtttaaaacaaagcctgaagatttccgggacctcagtttccccagacttaccatgatc acagagtacttgctgctcttccgagtatatgggcttgagagcctcaaggatcttttcccc aacttgacagtcattcgtgggtcccgcctctttttcaactacgccttggtcatctttgag atggtccacctcaaggagattggcctccacagcctaatgaacatcacccggggggctgtg cgcatcgagaagaataatgagctatgttacttgtcaaccatcgactggtctcagattcta gactcggtagaggacaactatatcgtggacaacaaagatgacaaagaagagtgtggggat gtctgccctggggcagtgaagggagtcaacagttgcaagtccacagtgatcaacggccag tttattgaacggtgctggacccacaaccattgccagaaagtgtgtccgccctcatgtaag tggcagggctgcacagcgagtggacagtgttgccacagtgaatgtttggggaactgctct gagcccaacgacccggagaagtgtgtggcctgccgaaatttctatctggatggcaagtgt gtggagacgtgccctccagactattaccacttccaggactggagatgtgtgaacttcagt gtctgtcaggagcttcacaataaatgtaaaaactcccggaagccctcgtgcccccagtat gtcatccacaacaacaggtgtatccctgagtgtccctctggctacacaatgaactccacc aacctgcattgttctccttgctccggcccctgtccaaaggtctgcaacatcgaggctgac cggaccattgattctgtgcatgctgcccaggcccttcgagggtgcaccgtcatcaacggg agccttgtcatcaacatccgtggtggcaataacatagcagccgaactagaagccaatctg ggtttaattgaggagatcacagggtaccttaagatccgtcgttcctatgccttagtatcc ctctccttcttccggaagctgcatctcattcgaggagagaccctggaaatcgggaactac tccttctatgccctggacaatcagaacctgaggcagctgtgggactggagcaaacacaac ctcaccatcgccaaggggaagctcttctttcactataaccccaaactctgcctgtctgaa atccacaaaatggaagaagtttctggcacaaagggccggcaggagaggaatgacattgca ctgaagaccaacggtgaccaagcttcttgtgaaaatgagctactcaggttttcttccatc agaacctctcatgacaaaatcttgctgagatgggagccttattggcctcctgatttccga gacctcttgggattcatgctgttctacaaagaagcgccttaccagaatgtgaccgagttt gatggccaggatgcctgtgggtccaatagctggacagtggttgacgttgaacccccagtg aggtcaaatgatcccaagacgcagaatcaacacccagggtggttgatgcgaaacctgaag ccgtggacccagtacgccatctttgtgaagaccctggtgaccttctctgatgaacggaga acctatggtgccaagagtgagatcatttacgtccagaccaatgccactgttccttcagtc ccattagacccaatatccgtttccaattcttcatcccagatcattttaaagtggaaacca ccctctgagccaaatggtaatattacacactacttagtgtactgggagaagcaagctgag gaccttgagctctacgaacttgattactgccttaaggggttaaagttgccatccaggacc tggtcccctccttttgagtctgaagattctcagaaacacaaccagagcaaccatgaggat cccaatggagagtgctgctcttgcccgaagactgactcccagatcttaaaggagctggag gagtcttcctttaggaagatgtttgaaaattaccttcacaacgaggttttcatccccaga aaagcatcctcagggaatggcgctgacgactctaggccggcaagaaggcgaagggatctc cgggttcgtatggcaaacatgaccgtggtgacgcccacgaggtcctcgctctccaacgcc tcttccaccacagcgcctgccagcaccgaggagccgaagcccttcgagaaggtgaagtct aaggagtccctggtcatctctggccttcagcattttactggctacaggatcgagctccag gcatgcaaccatgacgagcaggagtccaggtgtggcctcgccgcctatgtcagcgcgaga accatgcctgaagccaaagctgatgacattgttggtgcagtgacccacgaggtgcttgag aacgttgtccatctgcgatggcaagagcctaaacatcccaatggcctcattattctgtat gaagtcaattactggcgtgttggagacactgaggagctgcatctctgtgtttctcgaaaa cattacgcccacgaacagggctgcagacttcgaggtctacagcctggcaattacaccgtt cgcatccgagctacctctttggcgggaaatggttcatggactgagcacacctacttctat gttgcagattatttagatgttccatcgaatattgtaaaaattgtcatcggcccagtcatc attatcattttcttgatcagcacggttgcagctgtttatgtctttgtgaagaagaggcaa acggaaggaccaacaggcccactgttcgcctcttccaatccagaatacctcagtgccagt gatgtttatgtaccagacgagtgggaagtggctcgagagaaaatcagcctcctccgtgag cttggccaaggctcttttggcatggtctatgagggcaatgccaaggacatcgtcaagggg gaggccgagacccgcgtggccgtgaagacggtgaatgagtctgccagcctccgggaacgt attgagttcctgaatgaggcctctgtcatgaagggcttcagctgccatcatgtggtccgc ctcttgggggtggtctccaaagggcagcccaccctggtggtcatggagctgatggtacac ggggatctgaagagttatctccgctccctacggccagatgcagagaacaaccctggtcgc cctccccccaccctccgggagattatacagatggccgtggagattgcggatggcatggcc tatttgaatgctaagaaatttgttcacagagacctcgccgcccgaaactgtatggttgcc gaagactttactgtaaagataggagactttgggatgaccagagacatctatgagacagat tattatcgaaaagggggcaagggcttgctcccagtgaggtggatggcgccagaatcttta aaagatggtgtctttactacctattcagatgtatggtcttttggcgtggtgctgtgggag atcagcagcctggccgagcagccttaccaaggcctgtctaatgagcaggtcctgaaattt gtgatggatggagggtacctggaccaacccgataattgtccagagagagtgaacagcctg atgcagatgtgctggcagtataatcccaagatgcgtcccaccttcatcgagatcatcgag atgctgaaagatgacctccaccccagcttccgggaggtctcctttttttacagcgaggaa aacaagccccccgagagcgaggagtttgagatggactttgaaaatatggaaagcatcccc ctggacccgtcttcttactcacagagggatgaggtcctggggagggacaatgggccatcc ctgggccttaaggggaactatgaggagcggattccttatacccacatgaatgggggcaag aagaacgggcgcatcctctccttgccaaggtcgaacccttcctaa

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