Phascolarctos cinereus (koala): 110223514
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Entry
110223514 CDS
T05867
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
pcw
Phascolarctos cinereus (koala)
Pathway
pcw00310
Lysine degradation
pcw01100
Metabolic pathways
pcw05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
pcw00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
110223514 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
110223514 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
pcw03036
]
110223514 (DOT1L)
Enzymes [BR:
pcw01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
110223514 (DOT1L)
Chromosome and associated proteins [BR:
pcw03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
110223514 (DOT1L)
HMT complexes
Dot1-containing complex
110223514 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
DOT1
Motif
Other DBs
NCBI-GeneID:
110223514
NCBI-ProteinID:
XP_020864757
UniProt:
A0A6P5M1Y6
LinkDB
All DBs
Position
Unknown
AA seq
1758 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNTTTPTKVP
ENKGAVALEPRVDSGAEEDKNGTAALKKPSPSKPRKKKLNKKGRKMAGRKRGRPKKMSAA
NPERKPKKTPSALELLHAQTVSQAAASSPQDAYKSPHSPYYQLPPKVQRHSSNQLLATPT
PPALQKLLESFKVQYLQFLAYMKTPQYKANLQQLVEQEKEKNTQLLGTAQQLFSHCQAQK
EEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLKEQTKQLENDNSELRNQSLQLL
KARCEELKLDWSTLSLENLLKEKQALKNQISEKQKHCLELQISIVELEKSQRQQELLQLK
SSAPADEALSVHLRSKSSFSRELEADPARFQLDLECSKLSLPHLNSMSPELSMNGHATTY
EIHSMLSRPSSKQNTPQYLTSHLDQEIVPCTPIHNNRQKADKLSSLSLPDYTRYSPAKLA
LRRHLNQDHVVHGKATANEIHHRAEHAKENGLTYQSPGMSNGLKLSPQETRPSSPSALQI
AGEKSSDKVLKERAYASNGETITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAEKVRNT
PSPVHQNRESTSATLEKQFGANSHNGMNSAVGNKSLALATSGFSYSGSLAVNGTLSSSPA
HLNHGAEQAALDDSSNSGSLFNSVGSRSSTPQHPSLLMMQSRNSGQNSPTHPLAASPRLN
GASQSMMGILQYSDTTKLFSEGNNGDLPLDSGFSDPENEVKRRILFTISTNTGNLKQSPS
NKHSPLTASIRTDCGQACVQEGKKRGRRKRSSTGNPSVNSAVSPKRKPLPSVAGLFTQSS
GSPLNINSMVNNINQPLEITAISSPENSLKNSPIPYQDNDQPPVLKKEKPLIQTNGAHYS
PLTSDEEQGSEDEHNSIRIERKIATISLESKSPQKTENGGGLPGRKQSQLTEGINSSKWK
STFSPISDINLTKTSDSPLQAASSLSQNSLFAFRPSSEDTMALDAKISVHTRKNFPSSLS
GPDGLSPTTNSSNGFSYAGGLSAADMSLHSFHDGASLSHKTTEVASLSSPLGFQAQRSKD
GSDANPFLNKRQLDGLGSMKGEELQRAGGRSKEVLDVGLQLGGPSEKGSLQHSGKAGKGR
DRDLEFKNGHNLFISAAAAAVPPGGLLNGKGLSGAASAAGHPASSVSAHHPFLNTFTTGS
QFPLGPMSLQANLSSVAGSSVLQSLFNSMPAAASLVHVSSAATRLTNSHAMGNFSSGVTG
GTVGGVFNHAVPSASSHQFGASFCSSTMLSLNPVQAVVTPTSSSFQAPSSSIGTCSEARA
PQHLRPVQPVLHPPPPPPPAPPPANISLPPPPPLLAASNPEPGLLSTLTSVPANRAFIAP
SSAASLQANASLSIKLTSLPHKASLPSFTVHHQPLPRLALAQAAPVVPQSNTAGPPAMWV
TLGMQSPYASHLSGVKPR
NT seq
5277 nt
NT seq
+upstream
nt +downstream
nt
atgggtgagaagctggaactgaggctgaagtcgcccgtgggagccgagcccgccgtgtac
ccgtggcccctgccggtctatgacaaacatcatgatgctgctcatgaaatcattgagacc
attcgatgggtctgcgaagaaataccggatctcaagcttgccatggaaaattatgtttta
attgactatgataccaaaagctttgaaagcatgcagagactctgtgacaagtacaaccga
gccatcgatagcattcatcaactgtggaaaggaaccacccagcccatgaaattgaacact
cggccatctaatgggcttcttcgacatatcttgcagcaagtatataaccactcagtcacg
gatcccgagaaactcaacaactatgagcccttttctccagaggtgtatggagaaacttca
ttcgacttagttgcccaaatgattgatgagattaaaatgacagaggatgatttgtttgtt
gatttgggcagtggagtggggcaggtggttttacaagtggctgcagccacaaactgcaag
catcactatggtgtggagaaagcagacatcccggcgaagtatgctgagacaatggacaga
gaattcaggaaatggatgaaatggtatgggaagaagcatgcggaatacacactggaaaga
ggtgacttcctttcagaagaatggcgggaaagaattgcaaacacaagtgttatttttgtg
aataattttgcctttggtcctgaggtggatcaccaactgaaggagcgatttgctaacatg
aaggaaggtggcagaatcgtgtcctccaaaccttttgcacctctaaactttagaataaac
agtagaaacttgagtgatattggcactataatgagagttgtggagctatcaccactgaaa
gggtcggtttcatggactggcaagccagtttcttactacctgcatactattgatcgaacc
atacttgaaaactatttttctagtctcaaaaatccaaaactcagggaggagcaggaggca
gcccgccgccgacagcaaagagaaagcaagagcaacacgacgactccaacgaaggtcccg
gaaaacaagggagctgtggccttggagcctcgagtggattctggtgctgaagaagataaa
aatgggacggctgctcttaaaaagccatctccttccaagcctcgcaaaaagaaattaaac
aaaaaaggaaggaagatggcaggaagaaaacgtggacgccccaagaaaatgagtgctgca
aaccctgaacggaaacccaagaagactccaagtgcactggagcttctgcatgctcagact
gtgtcccaggcagctgcatcctctcctcaggatgcatacaagtcacctcatagtccatat
tatcaactacctcctaaagtacaacggcattcctccaaccagctattggcaactccaacc
ccacctgcactccagaagctattagaatcatttaaggttcagtacctgcagttcctggcc
tacatgaaaacccctcagtacaaggcaaacctgcagcagctggtggagcaggaaaaggaa
aagaacactcagttgttaggcacagcccagcagttgttcagccactgtcaggctcaaaaa
gaggagatcaagagactgtttcaacagaaacttgatgagttgggagttaaggctctgacc
tacaatgatctgatacaagctcagaaagagatctctgctcacaaccaacagctaaaagaa
cagacaaagcagctagaaaatgataacagtgaactcaggaaccaaagcttgcagctgctt
aaggctcggtgtgaagagctcaagctggattggtctactctctcactggaaaatttgctg
aaggagaagcaggcactgaagaatcaaatttctgagaagcaaaagcactgtctggaactt
cagatcagcattgtggagcttgagaagagccaaaggcagcaggaactactgcagctgaaa
tcctccgcgccggctgatgaggccctgtccgtccacctgcgaagcaaaagcagcttcagc
cgagagctggaggctgaccctgccaggttccagctggacttggagtgctccaagttgtcc
ttgccccacctcaatagcatgagccccgaactctctatgaatggccatgcgaccacctat
gagatccatagtatgcttagccgaccttcttccaaacaaaacactccacagtatctgacc
tcccacctggaccaagaaatagttccttgcacccccattcataacaacagacagaaggca
gacaagctgtcgagtttgtccttacctgattacaccaggtattcccctgctaagttagcc
ctaaggagacacttgaatcaggatcatgtagtccatggaaaagctacagctaatgaaata
caccacagagctgaacatgcaaaagagaatggcctgacatatcaaagtcctggtatgtca
aatggcctaaagctgagccctcaggaaactcggccttcctctccctcggccttacagatt
gcaggagagaagagcagtgacaaggttttaaaagagcgagcctatgccagcaatggagaa
acaatcaccagcctccctatcagtattcctctgagcacagtgcagcccaataaacttccc
gtcagtatcccattggccagtgtagtgttgcctagccgcgcggagaaagtgaggaacaca
cctagtccagttcatcagaatcgagaatctacttcagcaacacttgaaaaacagtttggt
gctaattcccataatggtatgaacagtgctgtaggaaacaagtcccttgctttggctacc
tcaggtttttcttatagtggctccttggcagtcaatggaacgctttccagtagcccagcc
catcttaaccatggtgctgagcaggcagccctagacgattcctccaattcagggagcctc
tttaattcagtgggttcacggagttctacgccacagcatccttctttactcatgatgcag
tcccggaactccggccagaactctccaacccacccacttgctgccagcccgcgcctcaat
ggagcttctcaaagcatgatggggattttgcagtactcggatactacaaaattgttctct
gaaggtaacaatggggatcttccactagattcaggcttttcagatcctgaaaatgaagtc
aagagaagaatcctctttacaatctcgaccaatacagggaacctgaagcagtctccttcc
aacaaacacagtcctctgacagctagcatccgcacagactgtggacaggcttgtgtgcag
gagggcaagaagaggggcagaaggaagcggtcttccacagggaaccccagtgtgaactct
gcggtatctcccaagcgcaagcccctaccgtcggtggcaggcctcttcacccagtcttca
ggctcacccctcaacatcaactctatggtcaataacattaatcagcctttagaaataaca
gccatttcctcccctgaaaactccctgaagaactctcctattccttaccaggacaacgac
cagcctcctgtgctgaaaaaggagaagcccctgatccagacgaatggggcgcactactca
cccctgacctcggatgaagagcagggatccgaagacgagcacaacagcatcaggattgaa
aggaaaatcgcaacaatctctttagagagcaagtctccccagaaaacagaaaatggtggt
ggccttccaggaaggaagcaaagtcagctaactgaaggcatcaacagcagtaaatggaag
tctaccttttcgccaatatcagacatcaaccttaccaaaacatctgacagccccttacag
gcagcttcgtccctgagccagaattccctgtttgccttccggccttcctcagaggatacg
atggctcttgatgctaagatctctgtgcacacgaggaaaaacttccccagttctttgtca
gggcctgatggtctcagccccaccacaaactcctccaatggtttctcctatgctggaggc
ctatctgctgctgacatgagtttacacagctttcatgatggtgcttctctttctcacaag
accaccgaggtggccagcttaagctcacctctgggttttcaggcacagcggagcaaagat
ggctcagacgccaacccttttctgaacaagaggcagctggacggcctgggaagcatgaag
ggggaggagctacagagggctggaggcagaagcaaggaggtgctcgacgtgggcctgcag
ctggggggtccttctgaaaagggctctctgcaacacagtggcaaggctggcaaaggacgg
gaccgggacttggagtttaaaaacggccacaatcttttcatttctgctgccgccgccgcc
gtacctcctggaggcctcctcaatggcaaaggcctttccggcgcggcctctgcggctggc
caccctgcttcttctgtttcggcgcaccacccttttttaaacactttcaccactggatcc
cagtttcccctgggccctatgtccctgcaggccaacctcagctcggtggcaggctcttca
gtattgcagtctttatttaattccatgcctgctgccgccagtttggtccacgtgtcatcg
gctgcgaccagattgaccaattctcacgctatgggaaacttctcttctggggttacaggt
ggaacagttggaggtgtttttaaccatgcggtgccttctgcctcttctcatcagtttgga
gccagtttctgtagcagcaccatgctaagcttaaacccagtgcaggctgtggtcaccccc
acttcctcttccttccaggccccttcctctagcataggaacatgtagcgaggctagagcc
ccccagcacctcaggcctgtgcagcctgtcctgcatcctcctcctcctcctccccccgct
cctcctcctgctaacatctcgttacctccaccccctccattactcgctgcttctaacccg
gagccggggcttctgtcgaccctaacgtctgttcccgctaacagagcttttattgcgccc
tcgtcggctgcttctctccaggctaacgcttctctgtctatcaagctcacttccctcccc
cacaaagcttcccttccctccttcacagtccatcaccagcctctgccccgtttggccctg
gcccaggctgcacccgtggtcccgcagtccaacaccgctggcccacccgctatgtgggtt
acccttggcatgcagtctccttacgcttcgcacctttctggggttaagccgcgataa
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integrated database retrieval system
