Pongo abelii (Sumatran orangutan): 100446021
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Entry
100446021 CDS
T01416
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
KO
K04368
mitogen-activated protein kinase kinase 1 [EC:
2.7.12.2
]
Organism
pon
Pongo abelii (Sumatran orangutan)
Pathway
pon01521
EGFR tyrosine kinase inhibitor resistance
pon01522
Endocrine resistance
pon04010
MAPK signaling pathway
pon04012
ErbB signaling pathway
pon04014
Ras signaling pathway
pon04015
Rap1 signaling pathway
pon04022
cGMP-PKG signaling pathway
pon04024
cAMP signaling pathway
pon04062
Chemokine signaling pathway
pon04066
HIF-1 signaling pathway
pon04068
FoxO signaling pathway
pon04071
Sphingolipid signaling pathway
pon04072
Phospholipase D signaling pathway
pon04114
Oocyte meiosis
pon04140
Autophagy - animal
pon04148
Efferocytosis
pon04150
mTOR signaling pathway
pon04151
PI3K-Akt signaling pathway
pon04210
Apoptosis
pon04218
Cellular senescence
pon04270
Vascular smooth muscle contraction
pon04370
VEGF signaling pathway
pon04371
Apelin signaling pathway
pon04380
Osteoclast differentiation
pon04510
Focal adhesion
pon04540
Gap junction
pon04550
Signaling pathways regulating pluripotency of stem cells
pon04613
Neutrophil extracellular trap formation
pon04620
Toll-like receptor signaling pathway
pon04650
Natural killer cell mediated cytotoxicity
pon04660
T cell receptor signaling pathway
pon04662
B cell receptor signaling pathway
pon04664
Fc epsilon RI signaling pathway
pon04666
Fc gamma R-mediated phagocytosis
pon04668
TNF signaling pathway
pon04720
Long-term potentiation
pon04722
Neurotrophin signaling pathway
pon04725
Cholinergic synapse
pon04726
Serotonergic synapse
pon04730
Long-term depression
pon04810
Regulation of actin cytoskeleton
pon04910
Insulin signaling pathway
pon04912
GnRH signaling pathway
pon04914
Progesterone-mediated oocyte maturation
pon04915
Estrogen signaling pathway
pon04916
Melanogenesis
pon04917
Prolactin signaling pathway
pon04919
Thyroid hormone signaling pathway
pon04921
Oxytocin signaling pathway
pon04926
Relaxin signaling pathway
pon04928
Parathyroid hormone synthesis, secretion and action
pon04929
GnRH secretion
pon04934
Cushing syndrome
pon04935
Growth hormone synthesis, secretion and action
pon05010
Alzheimer disease
pon05022
Pathways of neurodegeneration - multiple diseases
pon05034
Alcoholism
pon05132
Salmonella infection
pon05135
Yersinia infection
pon05160
Hepatitis C
pon05161
Hepatitis B
pon05163
Human cytomegalovirus infection
pon05164
Influenza A
pon05165
Human papillomavirus infection
pon05166
Human T-cell leukemia virus 1 infection
pon05167
Kaposi sarcoma-associated herpesvirus infection
pon05170
Human immunodeficiency virus 1 infection
pon05200
Pathways in cancer
pon05205
Proteoglycans in cancer
pon05206
MicroRNAs in cancer
pon05207
Chemical carcinogenesis - receptor activation
pon05208
Chemical carcinogenesis - reactive oxygen species
pon05210
Colorectal cancer
pon05211
Renal cell carcinoma
pon05212
Pancreatic cancer
pon05213
Endometrial cancer
pon05214
Glioma
pon05215
Prostate cancer
pon05216
Thyroid cancer
pon05218
Melanoma
pon05219
Bladder cancer
pon05220
Chronic myeloid leukemia
pon05221
Acute myeloid leukemia
pon05223
Non-small cell lung cancer
pon05224
Breast cancer
pon05225
Hepatocellular carcinoma
pon05226
Gastric cancer
pon05230
Central carbon metabolism in cancer
pon05231
Choline metabolism in cancer
pon05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
pon00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100446021 (MAP2K1)
04012 ErbB signaling pathway
100446021 (MAP2K1)
04014 Ras signaling pathway
100446021 (MAP2K1)
04015 Rap1 signaling pathway
100446021 (MAP2K1)
04370 VEGF signaling pathway
100446021 (MAP2K1)
04371 Apelin signaling pathway
100446021 (MAP2K1)
04668 TNF signaling pathway
100446021 (MAP2K1)
04066 HIF-1 signaling pathway
100446021 (MAP2K1)
04068 FoxO signaling pathway
100446021 (MAP2K1)
04072 Phospholipase D signaling pathway
100446021 (MAP2K1)
04071 Sphingolipid signaling pathway
100446021 (MAP2K1)
04024 cAMP signaling pathway
100446021 (MAP2K1)
04022 cGMP-PKG signaling pathway
100446021 (MAP2K1)
04151 PI3K-Akt signaling pathway
100446021 (MAP2K1)
04150 mTOR signaling pathway
100446021 (MAP2K1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
100446021 (MAP2K1)
04148 Efferocytosis
100446021 (MAP2K1)
09143 Cell growth and death
04114 Oocyte meiosis
100446021 (MAP2K1)
04210 Apoptosis
100446021 (MAP2K1)
04218 Cellular senescence
100446021 (MAP2K1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
100446021 (MAP2K1)
04540 Gap junction
100446021 (MAP2K1)
04550 Signaling pathways regulating pluripotency of stem cells
100446021 (MAP2K1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
100446021 (MAP2K1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
100446021 (MAP2K1)
04620 Toll-like receptor signaling pathway
100446021 (MAP2K1)
04650 Natural killer cell mediated cytotoxicity
100446021 (MAP2K1)
04660 T cell receptor signaling pathway
100446021 (MAP2K1)
04662 B cell receptor signaling pathway
100446021 (MAP2K1)
04664 Fc epsilon RI signaling pathway
100446021 (MAP2K1)
04666 Fc gamma R-mediated phagocytosis
100446021 (MAP2K1)
04062 Chemokine signaling pathway
100446021 (MAP2K1)
09152 Endocrine system
04910 Insulin signaling pathway
100446021 (MAP2K1)
04929 GnRH secretion
100446021 (MAP2K1)
04912 GnRH signaling pathway
100446021 (MAP2K1)
04915 Estrogen signaling pathway
100446021 (MAP2K1)
04914 Progesterone-mediated oocyte maturation
100446021 (MAP2K1)
04917 Prolactin signaling pathway
100446021 (MAP2K1)
04921 Oxytocin signaling pathway
100446021 (MAP2K1)
04926 Relaxin signaling pathway
100446021 (MAP2K1)
04935 Growth hormone synthesis, secretion and action
100446021 (MAP2K1)
04919 Thyroid hormone signaling pathway
100446021 (MAP2K1)
04928 Parathyroid hormone synthesis, secretion and action
100446021 (MAP2K1)
04916 Melanogenesis
100446021 (MAP2K1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100446021 (MAP2K1)
09156 Nervous system
04725 Cholinergic synapse
100446021 (MAP2K1)
04726 Serotonergic synapse
100446021 (MAP2K1)
04720 Long-term potentiation
100446021 (MAP2K1)
04730 Long-term depression
100446021 (MAP2K1)
04722 Neurotrophin signaling pathway
100446021 (MAP2K1)
09158 Development and regeneration
04380 Osteoclast differentiation
100446021 (MAP2K1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100446021 (MAP2K1)
05206 MicroRNAs in cancer
100446021 (MAP2K1)
05205 Proteoglycans in cancer
100446021 (MAP2K1)
05207 Chemical carcinogenesis - receptor activation
100446021 (MAP2K1)
05208 Chemical carcinogenesis - reactive oxygen species
100446021 (MAP2K1)
05230 Central carbon metabolism in cancer
100446021 (MAP2K1)
05231 Choline metabolism in cancer
100446021 (MAP2K1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
100446021 (MAP2K1)
09162 Cancer: specific types
05210 Colorectal cancer
100446021 (MAP2K1)
05212 Pancreatic cancer
100446021 (MAP2K1)
05225 Hepatocellular carcinoma
100446021 (MAP2K1)
05226 Gastric cancer
100446021 (MAP2K1)
05214 Glioma
100446021 (MAP2K1)
05216 Thyroid cancer
100446021 (MAP2K1)
05221 Acute myeloid leukemia
100446021 (MAP2K1)
05220 Chronic myeloid leukemia
100446021 (MAP2K1)
05218 Melanoma
100446021 (MAP2K1)
05211 Renal cell carcinoma
100446021 (MAP2K1)
05219 Bladder cancer
100446021 (MAP2K1)
05215 Prostate cancer
100446021 (MAP2K1)
05213 Endometrial cancer
100446021 (MAP2K1)
05224 Breast cancer
100446021 (MAP2K1)
05223 Non-small cell lung cancer
100446021 (MAP2K1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
100446021 (MAP2K1)
05170 Human immunodeficiency virus 1 infection
100446021 (MAP2K1)
05161 Hepatitis B
100446021 (MAP2K1)
05160 Hepatitis C
100446021 (MAP2K1)
05164 Influenza A
100446021 (MAP2K1)
05163 Human cytomegalovirus infection
100446021 (MAP2K1)
05167 Kaposi sarcoma-associated herpesvirus infection
100446021 (MAP2K1)
05165 Human papillomavirus infection
100446021 (MAP2K1)
09171 Infectious disease: bacterial
05132 Salmonella infection
100446021 (MAP2K1)
05135 Yersinia infection
100446021 (MAP2K1)
09164 Neurodegenerative disease
05010 Alzheimer disease
100446021 (MAP2K1)
05022 Pathways of neurodegeneration - multiple diseases
100446021 (MAP2K1)
09165 Substance dependence
05034 Alcoholism
100446021 (MAP2K1)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
100446021 (MAP2K1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100446021 (MAP2K1)
01522 Endocrine resistance
100446021 (MAP2K1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
pon01001
]
100446021 (MAP2K1)
Enzymes [BR:
pon01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
100446021 (MAP2K1)
Protein kinases [BR:
pon01001
]
Serine/threonine kinases: STE group
STE7 family
100446021 (MAP2K1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Seadorna_VP7
Haspin_kinase
Motif
Other DBs
NCBI-GeneID:
100446021
NCBI-ProteinID:
XP_024088586
LinkDB
All DBs
Position
15:46608675..46710049
Genome browser
AA seq
393 aa
AA seq
DB search
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAVGV
NT seq
1182 nt
NT seq
+upstream
nt +downstream
nt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctctgcggtt
aacgggaccagctctgcggagaccaacttggaggccttgcagaagaagctggaggagcta
gagcttgatgagcagcagcgaaagcgccttgaggcctttcttacccagaagcagaaggtg
ggagaactgaaggatgacgactttgagaagatcagtgagctgggggctggcaatggcggt
gtggtgttcaaggtctcccacaagccttctggcctggtcatggccagaaagctaattcat
ctggagatcaaacccgcaatccggaaccagatcataagggagctgcaggttctgcatgag
tgcaactctccgtacatcgtgggtttctatggtgcattctacagcgatggcgagatcagt
atctgcatggagcacatggatggaggttctctggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctg
agggagaagcacaagatcatgcacagagatgtcaagccctccaacatcctagtcaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactctatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tctgtgcagtcagacatctggagcatgggactctctctggtagagatggcggttgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagaccccacctaggccaaggacccctgggaggccccttagctcatat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgag
cctcctccaaaactgcccagtggagtgttcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacaccaacccatgctgttggcgtctaa
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