Pongo abelii (Sumatran orangutan): 100449849
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Entry
100449849 CDS
T01416
Symbol
PDE8B
Name
(RefSeq) high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X6
KO
K18437
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:
3.1.4.53
]
Organism
pon
Pongo abelii (Sumatran orangutan)
Pathway
pon00230
Purine metabolism
pon01100
Metabolic pathways
pon04927
Cortisol synthesis and secretion
pon04934
Cushing syndrome
pon05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
pon00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
100449849 (PDE8B)
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
100449849 (PDE8B)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
100449849 (PDE8B)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
100449849 (PDE8B)
Enzymes [BR:
pon01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
100449849 (PDE8B)
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GFIT
Motif
Pfam:
PDEase_I
PDE8
PAS_9
PAS
PAS_3
PAS_4
PAS_8
Motif
Other DBs
NCBI-GeneID:
100449849
NCBI-ProteinID:
XP_002815717
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Position
5:73459416..73710558
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AA seq
830 aa
AA seq
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MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG
PPSAARVRRARIELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV
RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII
VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME
NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFER
MMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVK
ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV
KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKDGLRRLSGNEYVFTKNVHQSHSHLA
MPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSET
TLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVH
DVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRT
LRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRM
MIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQIS
FIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS
NT seq
2493 nt
NT seq
+upstream
nt +downstream
nt
atgggctgcgcccccagcatccatgtctcgcagagcggcgtgatctactgccgggactcg
gacgagtccagctccccccgccaaaccaccagcgtgtcgcagggcccggcggcacccctg
cccggcctcttcgttcagaccgacgccgccgacgccatccctccgagccgcgcgtcggga
ccccccagcgcagcccgcgttcgcagggcccgcatcgagctgggcagcggtagcagcgcg
ggttccgcagcccccgccgcgaccaccagcaggggccggaggcgccactgctgcagcagc
gccgaggccgagactcagacctgctacaccagcgtgaagcaggtgtcttctgcggaggtg
cgcatcgggcccatgagactgacgcaggaccctattcaggttttgctgatctttgcaaag
gaagatagtcagagcgatggcttctggtgggcctgtgacagagctggttatagatgcaat
attgctcggactccagagtcagcccttgaatgctttcttgataagcatcatgaaattatt
gtaattgatcatagacaaactcagaacttcgatgcagaagcggtgtgcaggtcgatccgg
gccacaaatccctccgagcacacggtgatcctcgcagtggtttcgcgagtatcggatgac
catgaagaagcatcagtccttcctcttctccacgcaggcttcaacaggagatttatggag
aatagcagcataattgcttgctataatgaactgattcaaatagaacatggggaagttcgc
tcccagttcaaattacgggcctgtaattcagtgtttacagcattagatcactgtcatgaa
gccatagaaataacaagcgatgaccacgtgattcagtatgtcaacccagccttcgaaagg
atgatgggctaccacaaaggtgagctcctgggaaaagaactcgctgatctgcccaaaagc
gataagaaccgggcagaccttctcgacaccatcaatacatgcatcaagaagggaaaggag
tggcaaggggtttactatgccagacggaaatccggggacagcatccaacagcacgtgaag
atcaccccagtgattggccaaggagggaaaattaggcattttgtctccctcaagaaactg
tgttgtaccactgacaataataagcagattcacaagattcatcgtgattcaggagacaat
tctcagacagagcctcattcattcagatataagaacagaaggaaagagtccattgacgtg
aaatcgatatcatctcgaggcagtgatgcaccaagcctgcagaatcgtcgctatccgtcc
atggcgaggatccactccatgaccatcgaggctcccatcacaaaggacggcttgagaaga
ctgtcaggaaacgagtatgtgtttacgaagaatgtgcaccagagtcacagtcaccttgca
atgccaataaccatcaatgatgttcccccttgtatctctcaattacttgataatgaggag
agttgggacttcaacatctttgaactggaagccattacacataaaaggccattggtttac
ctgggcttaaaggtcttctctcggtttggagtatgtgaatttttaaactgttctgaaacc
actcttcgggcctggttccaagtgatcgaagccaactatcactcttccaatgcctaccac
aactccacccatgctgccgacgtcctgcacgccaccgctttcttcctcggaaaggaaaga
gtaaagggaagcctcgatcagctggatgaggtggcagccctcattgctgccacggtccat
gacgtggatcacccgggaaggaccaactctttcctctgcaatgcaggcagtgagcttgct
gtgctttacaatgacactgctgttctggagagtcatcacaccgccctggccttccagctc
actgtcaaggacaccaaatgcaacattttcaagaatattgacaggaaccattatcgaacg
ctgcgccaggctattattgacatggttttggcaacagagatgacaaaacactttgaacat
gtgaataagtttgtgaacagcatcaacaagccaatggcagctgagattgaaggcagcgac
tgtgaatgcaaccctgctgggaagaacttccctgaaaaccaaatcctgatcaaacgcatg
atgattaagtgtgctgacgtggccaacccatgccgccccttggacctgtgcattgaatgg
gctgggaggatctctgaggagtattttgcacagactgatgaagagaagagacaggggcta
cctgtggtgatgccagtgtttgaccggaatacctgtagcatccccaagtctcagatctct
ttcattgactacttcataacagacatgtttgatgcttgggatgcctttgcacatctgcca
gccctgatgcaacatttggctgacaactacaaacactggaagacactagatgacctaaaa
tgcaaaagtttgaggcttccatctgacagctaa
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