Pongo abelii (Sumatran orangutan): 100450564
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Entry
100450564 CDS
T01416
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
pon
Pongo abelii (Sumatran orangutan)
Pathway
pon00310
Lysine degradation
pon01100
Metabolic pathways
pon05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
pon00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
100450564 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
100450564 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
pon03036
]
100450564 (DOT1L)
Enzymes [BR:
pon01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
100450564 (DOT1L)
Chromosome and associated proteins [BR:
pon03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
100450564 (DOT1L)
HMT complexes
Dot1-containing complex
100450564 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
Motif
Other DBs
NCBI-GeneID:
100450564
NCBI-ProteinID:
XP_024093022
Ensembl:
ENSPPYG00000009340
LinkDB
All DBs
Position
19:1916172..1985993
Genome browser
AA seq
1738 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGP
EGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTA
NPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPT
PPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGHEKEKNAQLLGAAQQLLSHCQAQK
EEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRSQSLQLL
KARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCVPPDDALSLHLRGKSALGRELEPDASRLHLELDCAKFSLPHLSSMSPELSMNGQAAGY
ELCGALSRPSSKQNTPQYLASPLDQEVVPCTPSHGGRPRLEKLSGLAAPDYTRLSPAKIV
LRRHLSQDHAVPSRPATSELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQL
AGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARST
PSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALVGSPASLTPGA
EPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGATQGPL
PEASKGDLPSDSGFSDPESEAKRRIVFTIATGVGSAKQSPSSKHSPLTASARGDCVPSHG
QDSRKRGRRKRASTGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEI
TAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARI
ERKIATISLESKSPPKTLENGGGLAGRKPTPAGEPVNSSKWKSTFSPISDIGLAKSADSP
LQASSALGQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGG
GLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLK
GEGSRGKEAGEGGLPLCGPTDKTPLLTGKAAKARDRELDLKNGHNLFISAAAVPPGSLLS
GPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSS
VPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGVFNHAVPSASAHPFGARVGRGAAC
GSATLGPSPLQAAASASASSFQAPASVETRPPPPPPPPPPPLPPPAHLGRPPAGPPVLHA
PAPPNAALPPPPTLLASNPEPALLQSLASLPPNQAFLPPASAASLPPANASLSIKLTSLP
HKGARPSFTVHHQPLPRLALAQAAPGIPQASATGPSAVWVSLGMPPPYAAHLSGVKPR
NT seq
5217 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctggagctgagactaaagtcgcccgtgggggctgagcccgccgtctac
ccgtggcccctgccggtctacgataaacatcacgatgctgctcatgaaatcatcgagacc
atccgatgggtctgtgaagaaatcccggatctcaagcttgctatggagaattacgtttta
attgactatgacaccaaaagcttcgagagcatgcagaggctctgtgacaagtacaaccgt
gccatcgacagcatccaccagctgtggaagggcaccacgcagcctatgaagctgaacacg
cggccgtccaccgggctcctgcgccacatcctgcagcaggtctacaaccactcggtgacc
gaccccgagaagctcaacaactacgagcccttttcccccgaggtgtacggggagacctcc
ttcgacctggtggcccagatgattgatgagatcaagatgactgatgacgacctgtttgtg
gacttggggagcggtgtgggccaggtcgtgctccaggtcgccgctgccaccaactgcaaa
catcactatggcgtcgagaaagcagacatcccggccaagtatgcggagaccatggaccgc
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacattggagaga
ggcgatttcctctcagaagagtggagggagcgaatcgccaacacgagtgttatatttgtg
aataattttgcctttggtcctgaggtggatcaccagctgaaggagcggtttgcaaacatg
aaggaaggtggcagaattgtgtcctcgaaaccctttgcacctctgaacttcagaataaac
agtagaaacttgagtgacatcggcaccatcatgcgtgtggtggagctctcgcccctgaag
ggctcggtgtcgtggacggggaagccagtctcctactacctgcacactatcgaccgcacc
atacttgaaaactatttttctagtctgaaaaacccaaaactcagggaggaacaggaggca
gcccggcgccgccagcagcgtgagagcaagagcaacgcggccacgcccactaagggccca
gagggcaaggtggccggccccgccgacgcccccatggactctggtgctgaggaagagaag
gcgggagcagccaccgtgaagaagccgtctccctccaaagcccgcaagaagaagctaaac
aagaaggggaggaagatggccggccgcaagcgcgggcgccccaagaagatgaacactgcg
aaccccgagcggaagcccaagaagaaccaaactgcactggatgccctgcacgctcagacc
gtgtctcagacggcggcttcctcgccccaggatgcctacagatcccctcacagcccgttc
taccagctacctccgagcgtgcagcggcactcccccaacccgctgctggtggcgcccacc
ccgcccgcgctgcagaagctgctagagtccttcaagatccagtacctgcagttcctggca
tacacaaagaccccccagtacaaggccagcctgcaggagctgctgggacacgagaaggag
aagaacgcccagctcctgggcgcggctcagcagctcctcagccactgccaagcccagaag
gaggagatcaggaggctgttccagcaaaaattggatgagctgggcgtgaaggcgctgacc
tacaacgacctgattcaagcgcagaaggagatctccgcccataaccagcagctgcgggag
cagtcagagcagctggaacaggacaaccgcgcgctccgcagccagagcttgcagctgctc
aaggctcgctgcgaggagctgcagctggactgggccacactgtcgctggagaagctgctg
aaggagaagcaggccctgaagagccagatctcggaaaagcagaggcactgcctggagctg
cagatcagcattgtggagctagagaagagccagcggcagcaggagctcctgcagctcaag
tcctgtgtgccacctgatgacgccctgtccctgcacctgcgtgggaagagcgccctgggc
cgcgagctggagcctgacgccagccggctgcacctggagctggactgcgccaagttctcg
ctgcctcacttgagcagcatgagcccggagctctccatgaacggccaggctgctggctat
gagctctgtggtgcgctgagccggccctcgtccaagcagaacacgccccagtacctggcc
tcacccctggaccaggaggtggtgccctgcacccccagccacggcggccggccgcgcctg
gagaagctgtctggcctagctgcacccgactacactaggctgtccccggccaagattgtg
ctgaggcggcacctgagccaggaccacgcggtgcccagcaggccggccaccagtgagctg
cactcgagagctgagcacaccaaggagaacggccttccctaccagagccccagcgtgcct
ggcagcatgaagctgagccctcaggacccacggcccctgtcccctggggccttgcagctt
gctggagagaagagcagtgagaagggcctgagagagcgcgcctacggcagcagcggggag
ctcatcaccagcctgcccatcagcatcccgctcagcaccgtgcagcccaacaagctcccg
gtcagcatccctctggccagcgtggtgctgcccagccgcgccgagagggcgaggagcacc
cccagtcccgtgctgcagccccgtgacccctcgtccacacttgaaaagcagattggtgct
aatgcccacggtgctgggagcagaagccttgccctggcccccgcaggcttctcctacgct
ggctcggtggccatcagcggggccttggtgggcagcccggcctctctcacacctggagcc
gagccggccaccttggatgagtcctccagctctgggagcctttttgccaccgtggggtcc
cgcagctccacgccacagcaccccctgctgctggcacagccccggaactcgctcccggcc
tctcccgcccaccagctctcctccagtccccggcttggtggggccacccagggcccgctc
cccgaggccagcaagggggacctgccctccgattccggcttctcagatcctgagagtgaa
gccaagaggaggattgtgttcaccatcgccactggtgtgggcagtgccaagcagtcgccc
tccagcaagcacagccccctgaccgccagcgcccgtggggactgtgtgccgagccacggg
caggacagccgcaagcgcggcaggcggaagcgagcatctacggggacgcccagcttgagc
gcaggcgtgtcccccaagcgccgagccctgccgtccgtcgctggccttttcacacagcct
tcggggtctcccctcaacctcaactccatggtcagtaacatcaaccagcccctggagatt
acagccatctcgtcccccgagacgtccctgaagagctcccctgtgccctaccaggaccac
gaccagccccccgtgctcaagaaggagcggcctctgagccagaccaatggggcacactac
tccccactcacctcagacgaggagccaggctctgaggacgagcccagcagtgcccgaatt
gagagaaaaattgcaacaatctccttagaaagcaaatctcccccgaaaaccttggaaaat
ggtggtggcttggcgggaaggaagcccacgcccgccggcgagccagtcaatagcagcaag
tggaagtccaccttctcgcccatctccgacatcggcctggccaagtctgcagacagcccg
ctgcaggccagctccgccctcggccagaactccctgttcacgttccggcccgccctggag
gagccctctgccgatgccaagctggccgctcaccccaggaaaggctttcccggctccctg
tcgggggctgacggactcagcccgggcaccaaccctgccaacggctgcaccttcggcggg
ggcctggccgcggacctgagtttacacagcttcagtgatggtgcttctcttccccacaag
ggccccgaggcggccggcctgagctccccgctgagcttcccctcgcagcgcggcaaggag
gggtcggacgccaaccctttcctgagcaagaggcagctggacggcctggctgggctgaag
ggcgagggcagccgcggcaaggaggcaggggagggtggcctgccgctgtgcgggcccacg
gacaagacgccgctgctgaccggcaaggccgccaaggcccgggaccgcgagctcgacctc
aagaatggccacaacctcttcatctctgcggcggcggtgcctcccggaagcctcctcagc
ggccccggcctggccccggcggcgtcctccgcaggcggcgcggcgtcctccgcccagacg
caccggtccttcctgggccccttcccgccgggaccgcagttcgcgctcggccccatgtcc
ctgcaggccaacctcggctccgtggccggctcctccgtgctgcagtcgctgttcagctct
gtgccggccgccgcaggcctggtgcacgtgtcgtccgctgccaccagactgaccaactcg
cacgccatgggcagcttttccggggtggcaggcggcacagttggaggtgtctttaaccac
gcggtgccttccgcctctgctcatccgtttggagcccgtgtcggccgcggggctgcatgt
ggcagcgccacactgggcccgagcccgctgcaggcggcggccagcgcctcggcctcttcc
tttcaggccccggcctcggttgagacccggccgccccctccgcctccgcctccgcctccc
ccgctgcccccgccagcgcatctgggccggccccccgcggggccgcccgtccttcacgcc
cccgctccacctaacgccgccttgcctcctcccccaacgctgctggcctctaaccctgag
cccgcgcttctgcagagcctcgcgtccctcccgcctaaccaagctttcttgccccccgcc
tctgctgcctctctgccgcctgctaacgcctctttgtctatcaagctcacctccctcccg
cacaagggcgcccgcccctccttcacggtgcaccaccagcccctgccccggctggccctg
gcccaggccgcgcccgggatcccacaggccagcgccacggggccgtccgcggtgtgggtg
tccctcggcatgccgcctccctatgccgcgcacctttcgggggttaagccgcgataa
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