Pongo abelii (Sumatran orangutan): 100451422 Help Entry 100451422         CDS       T01416                                  Symbol INSR Name (RefSeq) insulin receptor isoform X1   KO K04527   insulin receptor [EC:2.7.10.1] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04010   MAPK signaling pathway pon04014   Ras signaling pathway pon04015   Rap1 signaling pathway pon04022   cGMP-PKG signaling pathway pon04066   HIF-1 signaling pathway pon04068   FoxO signaling pathway pon04072   Phospholipase D signaling pathway pon04150   mTOR signaling pathway pon04151   PI3K-Akt signaling pathway pon04152   AMPK signaling pathway pon04211   Longevity regulating pathway pon04213   Longevity regulating pathway - multiple species pon04520   Adherens junction pon04910   Insulin signaling pathway pon04913   Ovarian steroidogenesis pon04923   Regulation of lipolysis in adipocytes pon04930   Type II diabetes mellitus pon04931   Insulin resistance pon04932   Non-alcoholic fatty liver disease pon04960   Aldosterone-regulated sodium reabsorption pon05010   Alzheimer disease pon05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100451422 (INSR)    04014 Ras signaling pathway     100451422 (INSR)    04015 Rap1 signaling pathway     100451422 (INSR)    04066 HIF-1 signaling pathway     100451422 (INSR)    04068 FoxO signaling pathway     100451422 (INSR)    04072 Phospholipase D signaling pathway     100451422 (INSR)    04022 cGMP-PKG signaling pathway     100451422 (INSR)    04151 PI3K-Akt signaling pathway     100451422 (INSR)    04152 AMPK signaling pathway     100451422 (INSR)    04150 mTOR signaling pathway     100451422 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     100451422 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     100451422 (INSR)    04923 Regulation of lipolysis in adipocytes     100451422 (INSR)    04913 Ovarian steroidogenesis     100451422 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     100451422 (INSR)   09149 Aging    04211 Longevity regulating pathway     100451422 (INSR)    04213 Longevity regulating pathway - multiple species     100451422 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     100451422 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     100451422 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     100451422 (INSR)    04932 Non-alcoholic fatty liver disease     100451422 (INSR)    04931 Insulin resistance     100451422 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100451422 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:pon04090]     100451422 (INSR) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100451422 (INSR) Protein kinases [BR:pon01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    100451422 (INSR) CD molecules [BR:pon04090]  Proteins   100451422 (INSR) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like DUF4476 B2 Motif Other DBs NCBI-GeneID:  100451422 NCBI-ProteinID:  XP_024092866 LinkDB All DBs Position 19:complement(7065177..7245633) Genome browser AA seq 1370 aa AA seqDB search MGTGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHL QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQG CHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC TVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE RNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQ NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE RQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQIL KELEESSFRKTFEDYLHNVVFVPRPSRKRRSLGDVGNVTAAVPTVAAFPNTSSTSVPTSP EEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADD IVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCR LRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVI GSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPREKITLLRELGQG SFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGV VSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNA KKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGV FTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMC WQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRS SHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS NT seq 4113 nt NT seq  +upstreamnt  +downstreamnt atgggcaccgggggccggcggggggcggcggccgcgccgctgctggtggcggtggccgcg ctgctattgggcgccgcgggccacctgtaccccggagaggtgtgtcccggcatggatatc cggaacaacctcactaggttgcatgagctggagaattgctctgtcatcgaaggacacttg cagatactcttaatgttcaaaacgaggcccgaagatttccgagacctcagtttccccaaa ctcataatgatcactgattacttgctgctcttccgggtctatgggctcgagagcctgaag gacctgttccccaacctcacggtcatccggggatcacgactgttctttaactacgcgctg gtcatcttcgagatggttcacctcaaggaactcggcctctacaacctgatgaacatcacc cggggttctgtccgcatcgagaagaacaatgagctctgttacttggccactatcgactgg tcccgtatcctggattccgtggaggataattacatcgtattgaacaaagatgacaatgag gagtgtggagacatctgtccgggtaccgcaaagggcaagaccaactgccccgccactgtc atcaatgggcagtttgtcgaacgctgttggactcatagtcactgccagaaagtttgcccg accatctgtaagtcacacggctgcaccgccgaaggcctctgttgccacagcgagtgcctg ggcaactgttctgagcccgacgaccccaccaagtgcgtggcctgccgcaacttctacctg gacggcaggtgtgtggagacctgcccgcccccgtactaccacttccaggactggcgctgt gtgaacttcagcttctgccaggacctgcaccacaaatgcaagaactcgcggaggcagggc tgccaccagtacgtcattcacaacaacaagtgcatccctgagtgtccctccgggtacacg atgaattccagcaacttgctgtgcaccccatgcctgggtccctgtcccaaggtgtgccac ctcctagaaggcgagaagaccatcgactcggtgacatctgcccaggagctccgaggatgc accgtcatcaacgggagtctgatcatcaacattcgaggaggcaacaatctggcagctgag ctagaagccaacctcggcctcattgaagaaatttcagggtatctaaaaatccgccgatcc tacgctctggtgtcactttccttcttccggaagttacgtctgattcgaggagagaccttg gaaatcgggaactactccttctatgccttggacaaccagaacctaaggcagctctgggat tggagcaaacacaacctcaccatcactcaggggaaactcttcttccactataaccccaaa ctctgcttgtcagaaatccacaagatggaagaagtttcaggaaccaaggggcgccaggag agaaacgacattgccctgaagaccaatggggaccaggcatcctgtgaaaatgagttactt aaattttcttacattcggacatcttttgacaagatcttgctgagatgggagccgtactgg ccccccgacttccgagacctcttggggttcatgctgttctacaaagaggccccttatcag aatgtgacggagttcgacgggcaggatgcgtgtggttccaacagctggacggtggtagac attgacccacccctgaggtccaacgaccccaaatcacagaaccacccaggatggctgatg cggggtctcaagccctggacccagtatgccatctttgtgaagaccctggtcaccttttcg gatgaacgccggacctatggggccaagagtgacatcatttatgtccagacagatgccacc aacccctctgtgcccctggatccaatctcagtgtctaactcatcatcccagattattttg aagtggaaacccccctccgaccccaatggcaacatcacccactacctggttttctgggag aggcaggcggaagacagtgagctgttcgagctggattattgcctcaaagggctgaagctg ccctcgaggacctggtctccaccattcgagtctgaagattctcagaagcacaaccagagt gagtatgaggattcggccggcgaatgctgctcctgtccaaagacagactctcagatcctg aaggagctggaggagtcctcgtttaggaagacgtttgaggattacctgcacaacgtggtt tttgtccccaggccatctcggaaacgcaggtcccttggcgatgttgggaatgtgacagcg gctgtgcccacggtggcagctttccccaacacttcctcaaccagcgtgcccacgagtccg gaggagcacaggccctttgagaaggtggtaaacaaggagtcgctggtcatctctggcttg cgacacttcacaggctatcgcatcgagctgcaggcttgcaaccaagacacccctgaggaa cggtgcagtgtggcagcctacgtcagtgccaggaccatgcctgaagccaaggctgatgac atcgtcggccctgtgacgcacgaaatctttgagaacaacgttgtccacttgatgtggcag gagccgaaggagcccaatggtctgatcgtgctgtatgaagtgagttatcggcgatatggc gatgaggagctgcatctctgcgtctcccgcaagcacttcgctctggaacggggctgcagg ctgcgtgggctgtcgccggggaactacagcgtgcgagtccgggccacctcccttgcgggc aacggctcctggacggaacccacctatttctacgtgacagactatttagatgtcccgtca aatattgcaaaaattatcatcggccccctcatctttgtctttctcttcagtgttgtgatt ggaagtatttatctattcctgagaaagaggcagccagatgggccgctgggaccgctttac gcttcttcaaaccctgagtatctcagtgccagtgatgtgtttccatgctctgtgtacgtg ccggacgagtgggaggtgcctcgagagaagataaccctccttcgagagctggggcagggc tccttcggcatggtatatgagggcaacgccagggacatcatcaagggtgaggcagagacc cgtgtggcggtgaagacggtcaacgagtcagccagtctccgagagcggattgaattcctc aatgaggcctcggtcatgaagggcttcacctgccatcacgtggtgcgcctcctgggagtg gtgtccaagggccagcccacgctggtggtgatggagctgatggctcatggagacctgaag agctacctccgttctctgcggccagaggctgagaataatcctggccgccctccgcctacc ctgcaagagatgattcagatggcggcagagattgctgacgggatggcctacctgaacgcc aagaagtttgtgcatcgggacctggcagcgagaaactgcatggtcgcccatgattttact gtcaaaattggagactttggaatgaccagagacatctatgaaacggattactaccggaaa gggggtaagggtctgctccctgtacggtggatggcgccggagtccctgaaggatggggtc tttaccacttcttctgacatgtggtcctttggcgtggtcctttgggaaatcaccagcttg gcagaacagccttaccaaggcctgtctaatgaacaggtgttgaaatttgtcatggatgga gggtatctggatcaacccgacaactgtccagagagagtcactgacctcatgcgcatgtgc tggcaattcaaccccaagatgaggccaaccttcctggagattgtcaacctgctcaaggac gacctgcaccccagctttccggaggtgtcgttcttccacagcgaggagaacaaggctccc gagagtgaggagctggagatggagtttgaggacatggagaatgtgcccctggaccgttcc tcgcactgtcagagggaggaggcggggggccgggatggagggtcctcgctaggtttcaag cggagctacgaggaacacatcccttacacacacatgaacggaggcaagaaaaacgggcgg attctgaccttgcctcggtccaatccttcctaa

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