Panthera pardus (leopard): 109254164 Help Entry 109254164         CDS       T06062                                  Symbol INSR Name (RefSeq) insulin receptor isoform X1   KO K04527   insulin receptor [EC:2.7.10.1] Organism ppad  Panthera pardus (leopard) Pathway ppad04010   MAPK signaling pathway ppad04014   Ras signaling pathway ppad04015   Rap1 signaling pathway ppad04022   cGMP-PKG signaling pathway ppad04066   HIF-1 signaling pathway ppad04068   FoxO signaling pathway ppad04072   Phospholipase D signaling pathway ppad04150   mTOR signaling pathway ppad04151   PI3K-Akt signaling pathway ppad04152   AMPK signaling pathway ppad04211   Longevity regulating pathway ppad04213   Longevity regulating pathway - multiple species ppad04520   Adherens junction ppad04910   Insulin signaling pathway ppad04913   Ovarian steroidogenesis ppad04923   Regulation of lipolysis in adipocytes ppad04930   Type II diabetes mellitus ppad04931   Insulin resistance ppad04932   Non-alcoholic fatty liver disease ppad04960   Aldosterone-regulated sodium reabsorption ppad05010   Alzheimer disease ppad05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:ppad00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     109254164 (INSR)    04014 Ras signaling pathway     109254164 (INSR)    04015 Rap1 signaling pathway     109254164 (INSR)    04066 HIF-1 signaling pathway     109254164 (INSR)    04068 FoxO signaling pathway     109254164 (INSR)    04072 Phospholipase D signaling pathway     109254164 (INSR)    04022 cGMP-PKG signaling pathway     109254164 (INSR)    04151 PI3K-Akt signaling pathway     109254164 (INSR)    04152 AMPK signaling pathway     109254164 (INSR)    04150 mTOR signaling pathway     109254164 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     109254164 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     109254164 (INSR)    04923 Regulation of lipolysis in adipocytes     109254164 (INSR)    04913 Ovarian steroidogenesis     109254164 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     109254164 (INSR)   09149 Aging    04211 Longevity regulating pathway     109254164 (INSR)    04213 Longevity regulating pathway - multiple species     109254164 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     109254164 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     109254164 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     109254164 (INSR)    04932 Non-alcoholic fatty liver disease     109254164 (INSR)    04931 Insulin resistance     109254164 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:ppad01001]     109254164 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:ppad04090]     109254164 (INSR) Enzymes [BR:ppad01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      109254164 (INSR) Protein kinases [BR:ppad01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    109254164 (INSR) CD molecules [BR:ppad04090]  Proteins   109254164 (INSR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like B2 DUF4476 Motif Other DBs NCBI-GeneID:  109254164 NCBI-ProteinID:  XP_019283392 Ensembl:  ENSPPRG00000009528 LinkDB All DBs Position Unknown AA seq 1344 aa AA seqDB search MDIRNNLTRLHELANCSVIEGHLQILLMFKTRPEDFRDLSFPKLVMITDYLLLFRVYGLE SLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLAT IDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQK VCPTICKSHGCTADGLCCHSECLGNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQD WRCVNFSFCRDLHNKCKNSRRQGCHQYVIHNNRCIPECPSGYTMNSSNLMCTPCLGPCPK VCHILEGEKTIDSVTSAQELRGCTVVNGSLIINIRGGNNLAAELEANLGLIEEISGYLKI RRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHY NPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWE PYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPG WLMRGLKPWTQYAVFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQ IILKWKPPSDPNGNITHYLVFWERQAEDSELYELDYCLKGLKLPSRTWSPPFESEGSQKH NQSEYEESAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKSFSSPGAEDSRP SRKRRALADAGNVTAAVPTVPGFPNTSGSVPTSPEEHKPFEKVVNKESLVISGLRHFTGY RIELQACNQDAPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPN GLIVLYEVSYRRYGDEELHLCVSRRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSWTE ATYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPE YLSASDVFPCSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKT VNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMVHGDLKSYLRSL RPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDF GMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQ GLSNEQVLKFVMDGGYLDQPDNCPERVTDLMHMCWQFNPKMRPTFLEIVDLLKDDLHPSF PEVSFFHSEENKAPESEELEMEFEDMESVPLDRASHSQREEAGGRDGVSSLGLKRNYEDH IPYTHMNGGKKNGRILTLPRSNPS NT seq 4035 nt NT seq  +upstreamnt  +downstreamnt atggatatccggaacaacctgacgaggctgcacgaactggccaactgctcggtcattgaa ggtcatttgcagatactgctcatgttcaaaacgaggcccgaggacttccgagacctcagt ttccccaaactcgtcatgatcactgattacttgctgctctttcgggtgtacgggctggag agcctgaaggacctcttccccaacctcacggtcatccggggctcgcgcctcttcttcaac tacgcgctggtcatcttcgagatggtgcacctgaaggagcttggcctctacagcttgatg aacattacccggggctccgtccgcatcgagaagaacaatgagctgtgctacctggccacc atcgactggtcacgcatcctggattcggtggaggataattacattgtgttgaacaaagac gacaacgaggagtgtggggacatttgtccaggcaccgcaaagggcaagaccaactgccct gccactgtcatcaacgggcagtttgtggagcgatgttggacacacagccattgccagaaa gtttgtccgaccatctgcaagtcgcacggctgcacggccgacggcctctgctgccacagc gagtgtctgggcaactgctccgagcccgacgaccccaccaagtgcgtggcctgtcgcaac ttctacctggacggcaggtgcgtggagacctgcccgcccccctactaccacttccaagac tggcgctgcgtgaacttcagcttctgccgggacctgcacaataaatgcaagaactcccgg agacagggttgccaccagtatgtcattcacaacaacaggtgcatccctgagtgcccctcg gggtacacgatgaattccagcaacctgatgtgtactccctgcctgggcccctgtcccaag gtctgccacatcctggaaggcgagaagaccatcgactcggtgacatctgcccaggagctc cgaggctgcaccgtcgtcaacggaagcctaatcatcaacattcgagggggcaacaacctg gcagctgagctggaggccaacctcggactcattgaagaaatttctgggtacctgaagatc cgaaggtcctatgctcttgtgtcactttcctttttccggaagttacggctgattcgggga gagaccttggaaatcgggaactactctttctatgccttggacaaccagaacctgaggcag ctatgggactggagcaaacacaacctcaccatcactcaggggaaactcttcttccactat aatcccaaactctgcttgtcggaaattcacaagatggaggaggtttcaggaaccaagggg cgccaggagcggaacgacattgccctgaagaccaatggggaccaggcgtcttgtgaaaat gaactacttaaattttcttacattcggacatcttacgacaagatcttgctgaaatgggag ccgtactggccccctgacttccgagacctcctgggcttcatgctcttctacaaagaggcc ccttatcagaatgtgaccgagttcgacgggcaggacgcgtgtggctccaacagctggacg gtggtggacattgacccgcctctgaggtccaatgaccccaagtcgcagaaccacccaggg tggctgatgcggggtctcaagccctggacccagtatgctgtctttgtcaagaccttggtc accttttctgatgagcgccgcacgtatggggccaagagtgacatcatctatgtccagacc gatgccaccaacccttccgtccccctggatcctatctcggtttcgaattcctcctctcag atcattctgaagtggaagcctccctcggaccccaatggcaacatcacgcactacctggtg ttctgggagaggcaggcggaggacagtgagctgtatgagttggattattgcctcaaaggg ttgaagctgccttcccggacctggtccccgccgttcgagtccgagggctcccagaagcac aatcagagtgagtacgaggagtccgctggcgaatgctgctcgtgtcccaagaccgactct cagatcctgaaggagctggaggagtcctctttcaggaagacgttcgaggattacctgcac aatgtggttttcgtgcccagaaaatccttttcaagccctggtgctgaggacagtaggccg tcgcggaagcgcagggccctcgccgacgctgggaacgtgaccgccgccgtgcccacggtg cctggtttccccaacacttccggcagcgtgcccacgagcccggaagagcacaagcccttc gagaaggtggtgaacaaagagtctctggtcatctccggcctgcgtcacttcactggctac cgcatcgagctgcaggcttgcaaccaagatgcccccgaggagaggtgcagcgtggccgcc tacgtcagcgccaggaccatgcccgaagccaaggcagacgacattgttggccctgtgacc catgaaatcttcgagaacaacgtggttcacttgatgtggcaagagcctaaagaacccaat ggattgatcgtgctgtatgaagtgagttaccgacggtatggtgatgaggagctgcacctc tgtgtctcccgtagacactttgctctggagcggggctgcaggctgcgagggctgccgccg gggaattacagtgtgcgagttcgggccacctccctggcgggcaacggctcctggacagaa gccacttatttctatgtgacagactatttagatgtcccatcgaacattgcaaaaattatc atcgggcctctcatctttgtctttctcttcagtgttgtgattggaagtatttatctattc ctgagaaagaggcagccggatgggccactggggccgctgtatgcttcttcaaaccctgag tacctcagtgccagtgatgtgtttccctgctctgtgtatgtgccggacgagtgggaggtg cctcgggagaagatcactctcctgcgcgagctggggcagggctccttcggcatggtgtac gagggcaatgccagggacatcgtcaagggcgaggcggagacccgcgtggcggtgaagacg gtcaacgagtccgccagtctgcgagagaggatcgagtttctcaacgaggcctcagtcatg aagggcttcacctgtcatcacgtggtccgcctcctgggggtggtgtccaaaggccagccg acgctggtggtgatggagctgatggttcacggagacctgaagagctacctccgctccctg cggccggaggctgagaataaccctggccgccctccccctactctgcaagagatgattcag atggcggcggagatcgccgacgggatggcgtacctgaatgccaagaagtttgtgcaccgg gatctcgcagctcgaaattgcatggtggcccacgacttcaccgtcaaaattggagacttc ggaatgaccagagacatctatgaaacggattactaccggaaaggaggcaagggtctgctc cccgtgcggtggatggcaccggaatccctgaaggacggggtcttcaccacttcttctgac atgtggtcctttggtgtggtcctttgggaaatcaccagcttggcggaacaaccttaccaa ggcctgtctaatgaacaggtgttgaaatttgtcatggacggaggatatttggaccaacct gacaactgtccggagagagtcaccgacctgatgcacatgtgctggcagttcaatcccaag atgcggcccaccttcctggagatcgttgacctgctcaaggacgacctgcaccccagcttt ccggaagtttccttcttccacagcgaggagaacaaggcgcctgagagtgaggagttggaa atggagtttgaggacatggagagtgtccccctggatcgggcctcacactcacagagggaa gaggccgggggccgggatggagtgtcctcgctgggcctcaagcggaactacgaggaccac atcccctacacccacatgaacgggggcaagaaaaacggacggattctgaccctgccgagg tcgaatccttcctaa

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