KEGG   PATHWAY: ppt00260
Entry
ppt00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas putida S16
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ppt00260  Glycine, serine and threonine metabolism
ppt00260

Module
ppt_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ppt00260]
ppt_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ppt00260]
ppt_M00555  Betaine biosynthesis, choline => betaine [PATH:ppt00260]
ppt_M00621  Glycine cleavage system [PATH:ppt00260]
ppt_M00919  Ectoine degradation, ectoine => aspartate [PATH:ppt00260]
ppt_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:ppt00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas putida S16 [GN:ppt]
Gene
PPS_3817  aspartate kinase [KO:K00928] [EC:2.7.2.4]
PPS_1578  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
PPS_0664  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
PPS_1120  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
PPS_0086  homoserine kinase [KO:K02204] [EC:2.7.1.39]
PPS_0662  threonine synthase [KO:K01733] [EC:4.2.3.1]
PPS_1121  threonine synthase [KO:K01733] [EC:4.2.3.1]
PPS_0314  threonine aldolase [KO:K01620] [EC:4.1.2.48]
PPS_0668  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PPS_0315  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PPS_0819  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
PPS_2313  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
PPS_4429  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
PPS_2748  glycerate kinase [KO:K00865] [EC:2.7.1.165]
PPS_3704  hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
PPS_4902  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
PPS_5004  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PPS_1787  putative hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PPS_1409  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
PPS_4752  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
PPS_0484  short-chain dehydrogenase/reductase family oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
PPS_4827  amine oxidase [KO:K00274] [EC:1.4.3.4]
PPS_5045  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
PPS_1017  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
PPS_5047  glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
PPS_1015  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
PPS_3588  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
PPS_3808  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
PPS_5215  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
PPS_5046  glycine cleavage system protein H [KO:K02437]
PPS_1018  glycine cleavage system protein H [KO:K02437]
PPS_2272  creatinase [KO:K08688] [EC:3.5.3.3]
PPS_3171  phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
PPS_4520  CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
PPS_4910  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
PPS_4909  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
PPS_0708  putative betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
PPS_0308  Rieske (2Fe-2S) domain-containing protein [KO:K00479] [EC:1.14.13.251]
PPS_2308  Rieske (2Fe-2S) domain-containing protein [KO:K00479] [EC:1.14.13.251]
PPS_2327  iron-sulfur cluster-binding protein, rieske family [KO:K00479] [EC:1.14.13.251]
PPS_2307  iron-sulfur cluster-binding protein [KO:K21832] [EC:1.14.13.251]
PPS_0309  oxidoreductase FAD-binding domain-containing protein [KO:K21832] [EC:1.14.13.251]
PPS_0304  NADH:flavin oxidoreductase/NADH oxidase [KO:K21833] [EC:1.5.7.3]
PPS_0305  iron-sulfur cluster-binding protein [KO:K21834]
PPS_0306  electron transfer flavoprotein, alpha subunit [KO:K25960]
PPS_0307  electron transfer flavoprotein, alpha/beta-subunit-like protein [KO:K25961]
PPS_0318  sarcosine oxidase, alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
PPS_3267  glycine cleavage T protein (aminomethyl transferase) [KO:K00302] [EC:1.5.3.24 1.5.3.1]
PPS_3265  FAD dependent oxidoreductase [KO:K00303] [EC:1.5.3.24 1.5.3.1]
PPS_0316  sarcosine oxidase, beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
PPS_0319  sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
PPS_3268  conserved hypothetical protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
PPS_0317  sarcosine oxidase, delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
PPS_3266  sarcosine oxidase, delta subunit heterotetrameric [KO:K00304] [EC:1.5.3.24 1.5.3.1]
PPS_3955  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
PPS_2783  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
PPS_1016  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
PPS_0291  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
PPS_2925  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
PPS_4997  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
PPS_0717  EutB ectoine utilization protein [KO:K01754] [EC:4.3.1.19]
PPS_2985  putative L-serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
PPS_3183  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
PPS_3190  alanine racemase [KO:K25317] [EC:5.1.1.10]
PPS_0044  tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
PPS_0045  tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
PPS_3617  diaminobutyrate-2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
PPS_0719  EutD ectoine utilization protein [KO:K15783] [EC:3.5.4.44]
PPS_0720  EutE ectoine utilization protein [KO:K15784] [EC:3.5.1.125]
PPS_0722  aminotransferase class-III family protein [KO:K15785] [EC:2.6.1.76]
PPS_0721  succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ppt00010  Glycolysis / Gluconeogenesis
ppt00020  Citrate cycle (TCA cycle)
ppt00230  Purine metabolism
ppt00250  Alanine, aspartate and glutamate metabolism
ppt00270  Cysteine and methionine metabolism
ppt00290  Valine, leucine and isoleucine biosynthesis
ppt00300  Lysine biosynthesis
ppt00330  Arginine and proline metabolism
ppt00460  Cyanoamino acid metabolism
ppt00470  D-Amino acid metabolism
ppt00564  Glycerophospholipid metabolism
ppt00620  Pyruvate metabolism
ppt00630  Glyoxylate and dicarboxylate metabolism
ppt00640  Propanoate metabolism
ppt00680  Methane metabolism
ppt00860  Porphyrin metabolism
ppt00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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