Panthera tigris altaica (Amur tiger): 102963682
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Entry
102963682 CDS
T02988
Symbol
PDHA1
Name
(RefSeq) pyruvate dehydrogenase (lipoamide) alpha 1
KO
K00161
pyruvate dehydrogenase E1 component subunit alpha [EC:
1.2.4.1
]
Organism
ptg
Panthera tigris altaica (Amur tiger)
Pathway
ptg00010
Glycolysis / Gluconeogenesis
ptg00020
Citrate cycle (TCA cycle)
ptg00620
Pyruvate metabolism
ptg00785
Lipoic acid metabolism
ptg01100
Metabolic pathways
ptg01200
Carbon metabolism
ptg01210
2-Oxocarboxylic acid metabolism
ptg04066
HIF-1 signaling pathway
ptg04922
Glucagon signaling pathway
ptg05230
Central carbon metabolism in cancer
ptg05415
Diabetic cardiomyopathy
Module
ptg_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
ptg00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
102963682 (PDHA1)
00020 Citrate cycle (TCA cycle)
102963682 (PDHA1)
00620 Pyruvate metabolism
102963682 (PDHA1)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
102963682 (PDHA1)
09130 Environmental Information Processing
09132 Signal transduction
04066 HIF-1 signaling pathway
102963682 (PDHA1)
09150 Organismal Systems
09152 Endocrine system
04922 Glucagon signaling pathway
102963682 (PDHA1)
09160 Human Diseases
09161 Cancer: overview
05230 Central carbon metabolism in cancer
102963682 (PDHA1)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
102963682 (PDHA1)
Enzymes [BR:
ptg01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
102963682 (PDHA1)
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Ortholog
Paralog
GFIT
Motif
Pfam:
E1_dh
DXP_synthase_N
TPP_enzyme_C
Motif
Other DBs
NCBI-GeneID:
102963682
NCBI-ProteinID:
XP_015396736
LinkDB
All DBs
Position
Un
AA seq
457 aa
AA seq
DB search
MGLEVNEDDIQEPVEERGQELTTEETTDLHRELQQEATEEISSAKEEGKKAEGSLTSSEI
REMCEMWEEVRNCVEKHHPNKAAAFKASRVLVASRNFANDATFEIKKCDLHRLEEGPPVT
TVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDH
LITAYRAHGFTFTRGLSVREILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPL
GAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSV
ERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHS
MSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFA
TADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSIS
NT seq
1374 nt
NT seq
+upstream
nt +downstream
nt
atgggactggaggtgaatgaggatgacattcaggagccggtggaggaacgtggccaggag
ctgaccactgaggaaacgacggatctgcatcgagagctacagcaagaggctacggaggag
atctcctctgcaaaggaggaggggaaaaaggcagagggatccctcacttcaagtgagatt
agggagatgtgtgaaatgtgggaagaagtgcgaaattgtgtagaaaagcaccacccgaat
aaggctgcagcattcaaggcaagcagagtgctggtggcatcccgtaattttgcaaatgat
gctacatttgaaattaagaaatgtgatcttcaccgactggaagagggccctcctgtcacc
acggtactcaccagggaggatgggctcaaatactataggatgatgcagactgttcgccga
atggaattaaaggcagatcagctgtataaacagaaaattattcgtggtttttgtcacttg
tgtgatggtcaggaagcttgttgtgtgggcctggaggccggcataaatcccacagaccat
cttatcacagcctatcgggctcatggcttcacctttactcgtggactttctgtccgagaa
attcttgcagagcttacaggacgaagaggaggttgcgctaaagggaaaggcggatcgatg
catatgtatgccaaaaacttctacgggggcaacggcatcgtcggagctcaggtgcccctg
ggagcagggattgctctggcctgtaagtataacggaaaggatgaggtctgtttgacttta
tatggcgatggtgctgctaaccaaggtcagatattcgaagcttacaatatggcagctttg
tggaaattgccatgtattttcatctgtgaaaataaccgctatggaatgggaacatctgtt
gagagagcagcggccagcacggattactacaagagaggtgacttcattcctgggctgagg
gtagatggaatggatatcctgtgtgtccgggaggcgacgaggtttgcagccgcctactgt
agatctggaaaggggcccatactgatggagctacagacttaccgctaccacggacatagc
atgagtgaccctggtgtcagttaccgtacacgagaggagattcaggaagtaagaagtaag
agtgaccctattatgcttctcaaggatagaatggtgaacagcaacctggccagtgttgaa
gaattaaaggaaattgatgttgaagtgaggaaagaaattgaggatgctgcccagtttgcc
accgctgatcctgaaccgcctttggaagaactaggctatcacatttacagcagcgaccca
ccttttgaagttcggggtgcaaatcagtggatcaagtttaagtccatcagttaa
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