Panthera tigris altaica (Amur tiger): 102967156 Help Entry 102967156         CDS       T02988                                  Symbol INSR Name (RefSeq) insulin receptor   KO K04527   insulin receptor [EC:2.7.10.1] Organism ptg  Panthera tigris altaica (Amur tiger) Pathway ptg04010   MAPK signaling pathway ptg04014   Ras signaling pathway ptg04015   Rap1 signaling pathway ptg04022   cGMP-PKG signaling pathway ptg04066   HIF-1 signaling pathway ptg04068   FoxO signaling pathway ptg04072   Phospholipase D signaling pathway ptg04150   mTOR signaling pathway ptg04151   PI3K-Akt signaling pathway ptg04152   AMPK signaling pathway ptg04211   Longevity regulating pathway ptg04213   Longevity regulating pathway - multiple species ptg04520   Adherens junction ptg04910   Insulin signaling pathway ptg04913   Ovarian steroidogenesis ptg04923   Regulation of lipolysis in adipocytes ptg04930   Type II diabetes mellitus ptg04931   Insulin resistance ptg04932   Non-alcoholic fatty liver disease ptg04960   Aldosterone-regulated sodium reabsorption ptg05010   Alzheimer disease ptg05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:ptg00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     102967156 (INSR)    04014 Ras signaling pathway     102967156 (INSR)    04015 Rap1 signaling pathway     102967156 (INSR)    04066 HIF-1 signaling pathway     102967156 (INSR)    04068 FoxO signaling pathway     102967156 (INSR)    04072 Phospholipase D signaling pathway     102967156 (INSR)    04022 cGMP-PKG signaling pathway     102967156 (INSR)    04151 PI3K-Akt signaling pathway     102967156 (INSR)    04152 AMPK signaling pathway     102967156 (INSR)    04150 mTOR signaling pathway     102967156 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     102967156 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     102967156 (INSR)    04923 Regulation of lipolysis in adipocytes     102967156 (INSR)    04913 Ovarian steroidogenesis     102967156 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     102967156 (INSR)   09149 Aging    04211 Longevity regulating pathway     102967156 (INSR)    04213 Longevity regulating pathway - multiple species     102967156 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     102967156 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     102967156 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     102967156 (INSR)    04932 Non-alcoholic fatty liver disease     102967156 (INSR)    04931 Insulin resistance     102967156 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:ptg01001]     102967156 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:ptg04090]     102967156 (INSR) Enzymes [BR:ptg01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      102967156 (INSR) Protein kinases [BR:ptg01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    102967156 (INSR) CD molecules [BR:ptg04090]  Proteins   102967156 (INSR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like B2 DUF4476 Motif Other DBs NCBI-GeneID:  102967156 NCBI-ProteinID:  XP_015396824 LinkDB All DBs Position Un AA seq 1344 aa AA seqDB search MDIRNNLTRLHELANCSVIEGHLQILLMFKTRPEDFRDLSFPKLVMITDYLLLFRVYGLE SLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLAT IDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQK VCPTICKSHGCTADGLCCHSECLGNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQD WRCVNFSFCRDLHNKCKNSRRQGCHQYVIHNNRCIPECPSGYTMNSSNLMCTPCLGPCPK VCHILEGEKTIDSVTSAQELRGCTVVNGSLIINIRGGNNLAAELEANLGLIEEISGYLKI RRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHY NPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWE PYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPG WLMRGLKPWTQYAVFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQ IILKWKPPSDPNGNITHYLVFWERQAEDSELYELDYCLKGLKLPSRTWSPPFESEGSQKH NQSEYEESAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKSFSSPGAEDSRP SRKRRALADAGNVTAAVPTVPGFPNTSSSVPTSPEEHKPFEKVVNKESLVISGLRHFTGY RIELQACNQDAPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPN GLIVLYEVSYRRYGDEELHLCVSRRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSWTE ATYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPE YLSASDVFPCSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKT VNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMVHGDLKSYLRSL RPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDF GMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQ GLSNEQVLKFVMDGGYLDQPDNCPERVTDLMHMCWQFNPKMRPTFLEIVDLLKDDLHPSF PEVSFFHSEENKAPESEELEMEFEDMESVPLDRASHSQREEAGGRDGVSSLGLKRNYEDH IPYTHMNGGKKNGRILTLPRSNPS NT seq 4035 nt NT seq  +upstreamnt  +downstreamnt atggatatccggaacaacctgacgaggctgcacgaactggccaactgctcggtcattgaa ggtcatttgcagatactgctcatgttcaaaacgcggcccgaggacttccgagacctcagt ttccccaaactcgtcatgatcactgattacttgctgctcttccgggtgtatgggctggag agcctgaaggacctcttccccaacctcacggtcatccggggctcgcgcctcttcttcaac tacgcgctggtcatcttcgagatggtgcacctgaaggagcttggcctctacagcttgatg aacattacccggggctccgtccgcatcgagaagaacaatgagctgtgctacctggccacc atcgactggtcacgcatcctggattcggtggaggataattacattgtgttgaacaaagac gacaacgaggagtgtggggacatttgtccaggcaccgcaaagggcaagaccaactgccct gccactgtcatcaacgggcagtttgtggagcgatgttggacacacagccattgccagaaa gtttgtccgaccatctgcaagtcgcacggctgcacggccgacggcctctgctgccacagc gagtgtctgggcaactgctccgagcccgacgaccccaccaagtgcgtggcctgtcgcaac ttctacctggacggcaggtgcgtggagacctgcccgcccccctactaccacttccaagac tggcgctgcgtgaacttcagcttctgccgggacctgcacaataaatgcaagaactcccgg agacagggttgccaccagtatgtcattcacaacaacaggtgcatccctgagtgcccctcg gggtacacgatgaattccagcaacctgatgtgtactccctgcctgggcccctgtcccaag gtctgccacatcctggaaggcgagaagaccatcgactcggtgacatctgcccaggagctc cgaggctgcaccgtcgtcaacggaagcctaatcatcaacattcgagggggcaacaacctg gcagctgagctggaggccaacctcggactcattgaagaaatttctgggtacctgaagatc cgaaggtcctatgctcttgtgtcactttcctttttccggaagttacggctgattcgggga gagaccttggaaatcgggaactactctttctatgccttggacaaccagaacctgaggcag ctatgggactggagcaaacacaacctcaccatcactcaggggaaactcttcttccactat aatcccaaactctgcttgtcggaaattcacaagatggaggaggtttcaggaaccaagggg cgccaggagcggaacgacattgccctgaagaccaatggggaccaggcgtcttgtgaaaat gaactacttaaattttcttacattcggacatcttacgacaagatcttgctgaaatgggag ccgtactggccccctgacttccgagacctcctgggcttcatgctcttctacaaagaggcc ccttatcagaatgtgaccgagttcgacgggcaggacgcgtgtggctccaacagctggacg gtggtggacattgacccgcctctgaggtccaatgaccccaagtcgcagaaccacccaggg tggctgatgcggggtctgaagccctggacccagtatgctgtctttgtcaagaccttggtc accttttctgatgagcgccgcacgtatggggccaagagtgacatcatctatgtccagacc gatgccaccaacccttccgtccccctggatcctatctcggtttcgaattcctcctctcag atcattctgaagtggaagcctccctcggaccccaatggcaacatcacgcactacctggtg ttctgggagaggcaggcggaggacagtgagctgtatgagttggattattgcctcaaaggg ttgaagctgccttcccggacctggtccccgccgttcgagtccgagggctcccagaagcac aatcagagtgagtacgaggagtccgctggcgaatgctgctcgtgtcccaagaccgactct cagatcctgaaggagctggaggagtcttctttcaggaagacgttcgaggattacctgcac aatgtggttttcgtgcccagaaaatccttttcaagccctggtgctgaggacagtaggccg tcgcggaagcgcagggccctcgccgacgctgggaacgtgaccgccgccgtgcccacggtg cctggtttccccaacacttccagcagcgtgcccacgagcccggaagagcacaagcccttc gagaaggtggtgaacaaagagtctctggtcatctccggcctgcgtcacttcaccggctac cgcatcgagctgcaggcttgcaaccaagatgcccccgaggagaggtgcagcgtggccgcc tacgtcagcgccaggaccatgcccgaagccaaggcagacgacattgttggccctgtgacc catgaaatcttcgagaacaacgtggttcacttgatgtggcaagagcctaaagaacccaat ggattgatcgtgctgtatgaagtgagttaccgacggtatggtgatgaggagctgcacctc tgtgtctcccgtagacactttgctctggagcggggctgcaggctgcgagggctgccgccg gggaattacagtgtgcgagttcgggccacctccctggcgggcaacggctcctggacagaa gccacttatttctatgtgacagactatttagatgtcccatcgaacattgcaaaaattatc atcgggcctctcatctttgtctttctcttcagtgttgtgattggaagtatttatctattc ctgagaaagaggcagccggatgggccactggggccgctgtatgcttcttcaaaccctgag tacctcagtgccagtgatgtgtttccctgctctgtgtatgtgccggacgagtgggaggtg cctcgggagaagatcactctcctgcgcgagctggggcagggctccttcggcatggtgtac gagggcaatgccagggacatcgtcaagggcgaggcggagacccgcgtggcggtgaagacg gtcaacgagtccgccagtctgcgagagaggatcgagtttctcaacgaggcctcagtcatg aagggcttcacttgtcatcacgtggtccgcctcctgggggtggtgtccaaaggccagccg acgctggtggtgatggagctgatggttcacggagacctgaagagctacctccgctccctg cggccggaggctgagaataaccctggccgccctccccctactctgcaagagatgattcag atggcggcggagatcgccgacgggatggcgtacctgaatgccaagaagtttgtgcaccgg gatctcgcagctcgaaattgcatggtggcccacgacttcaccgtcaaaattggagacttc ggaatgaccagagacatctatgaaacggattactaccggaaaggaggcaagggtctgctc cccgtgcggtggatggcaccggaatccctgaaggacggggtcttcaccacttcttctgac atgtggtcctttggtgtggtcctttgggaaatcaccagcttggcggaacaaccttaccaa ggcctgtctaatgaacaggtgttgaaatttgtcatggacggaggatatttggaccaacct gacaactgtccggagagagtcaccgacctgatgcacatgtgctggcagttcaatcccaag atgcggcccaccttcctggagatcgttgacctgctcaaagacgacctgcaccccagcttt ccggaagtctccttcttccacagcgaggagaacaaggcgcctgagagtgaggagttggaa atggagtttgaggacatggagagtgtccccctggatcgggcctcacactcacagagggaa gaggccgggggccgggatggagtgtcctcgctgggcctcaagcggaactacgaggaccac atcccctacacccacatgaacgggggcaagaaaaacggacggattctgaccctgccgagg tcgaatccttcctaa

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