Pan troglodytes (chimpanzee): 455566
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Entry
455566 CDS
T01005
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
ptr
Pan troglodytes (chimpanzee)
Pathway
ptr00310
Lysine degradation
ptr01100
Metabolic pathways
ptr05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
ptr00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
455566 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
455566 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
ptr03036
]
455566 (DOT1L)
Enzymes [BR:
ptr01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
455566 (DOT1L)
Chromosome and associated proteins [BR:
ptr03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
455566 (DOT1L)
HMT complexes
Dot1-containing complex
455566 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
Motif
Other DBs
NCBI-GeneID:
455566
NCBI-ProteinID:
XP_016790120
Ensembl:
ENSPTRG00000010225
VGNC:
7478
LinkDB
All DBs
Position
19:2024965..2094105
Genome browser
AA seq
1684 aa
AA seq
DB search
MENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQV
YNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVA
AATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIAN
TSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVV
ELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAA
TPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRP
KKMNTANPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNP
LLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLS
HCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRG
QSLQLLKARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQ
ELLQLKSCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMN
GQAAGYELCGALSRPPSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRL
SPAKIVLRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLS
PGALQLAGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRA
ERARSTPSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPA
SLTPGAEPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGG
ATQGPLPEATKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTTSARGD
CVPSHGQDSRKRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNI
NQPLEITAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDE
PSSARIERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLA
KSADSPLQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPAN
GCTFGGGLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLD
GLAGLKGEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDRELDLKNGHNLFISAAAVP
PGSLLSGPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVL
QSLFSSVPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGVFNHAVPSASAHPFGARV
GRGAACGSATLGPSPLQAAASASASSFQAPASVETRPPPPPPPPPPPLPPPAHLGRSPAG
PPVLHAPPPPNAALPPPPTLLASNPEPALLQSLASLPPNQAFLPPTSAASLPPANASLSI
KLTSLPHKGARPSFTVHHQPLPRLALAQAAPGIPQASATGPSAVWVSLGMPPPYAAHLSG
VKPR
NT seq
5055 nt
NT seq
+upstream
nt +downstream
nt
atggagaattacgttttaattgactatgacaccaaaagcttcgagagcatgcagaggctc
tgcgacaagtacaaccgtgccattgacagcatccaccagctgtggaagggcaccacgcag
cccatgaagctgaacacgcggccgtccactggactcctgcgccatatcctgcagcaggtc
tacaaccactcggtgaccgaccccgagaagctcaacaactacgagcccttctcccccgag
gtgtacggggagacctccttcgacctggtggcccagatgattgacgagatcaagatgacc
gacgacgacctgtttgtggacttggggagcggtgtgggtcaggtcgtgctccaggttgct
gctgccaccaactgcaaacatcactatggcgtcgagaaagcagacatcccggccaagtat
gcggagaccatggaccgcgagttcaggaagtggatgaaatggtatggaaaaaagcatgca
gaatacacattggagagaggcgatttcctctcagaagagtggagggagcgaatcgccaac
acgagtgttatatttgtgaataattttgcctttggtcctgaggtggatcaccagctgaag
gagcggtttgcaaacatgaaggaaggtggcagaatcgtgtcctcgaaaccctttgcacct
ctgaacttcagaataaacagtagaaacttgagtgacatcggcaccatcatgcgcgtggtg
gagctctcgcccctgaagggctcggtgtcgtggacggggaagccagtctcctactacctg
cacactatcgaccgcaccatacttgaaaactatttttctagtctgaaaaacccaaaactc
agggaggaacaggaggcagcccggcgccgccagcagcgcgagagcaagagtaacgcggcc
acgcccactaagggcccagagggcaaggtggccggccccgccgacgcccccatggactct
ggtgctgaggaagagaaggcgggagcagccaccgtgaagaagccgtctccctccaaagcc
cgcaagaagaagctaaacaagaaggggaggaagatggctggccgcaagcgcgggcgcccc
aagaagatgaacactgcgaaccccgagcggaagcccaagaagaaccaaactgcactggat
gccctgcacgctcagaccgtgtctcagacggcggcctcctcaccccaggatgcctacaga
tcccctcacagcccgttctaccagctacctccgagcgtgcagcggcactcccccaacccg
ctgctggtggcgcccaccccgcccgcgctgcagaagctgctagagtccttcaagatccag
tacctgcagttcctggcatacacaaagaccccccagtacaaggccagcctgcaggagctg
ctgggccaggagaaggagaagaacgcccagctcctgggtgcggctcagcagctcctcagc
cactgccaggcccagaaggaggagatcaggaggctgttccagcaaaaattggatgagctg
ggtgtgaaggcgctgacctacaatgacctgattcaagcgcagaaggagatctccgcccat
aaccagcagctgcgggagcagtcggagcagctggagcaggacaaccgcgcgctccgcggc
cagagcttgcagctgctcaaggctcgctgcgaggagctgcagctggactgggccacgctg
tcgctggagaagctgttgaaggagaagcaggccctgaagagccagatctcggagaagcag
aggcactgcctggagctgcagatcagcattgtggagctagagaagagccagcggcagcag
gagctcctgcagctcaagtcctgtgtgccgcctgacgatgccctgtccctgcacctgcgt
gggaagggcgccctgggccgcgagctggagcctgacgccagccggctgcacctggagctg
gactgcaccaagttctcgctgcctcacttgagcagcatgagcccggagctctccatgaac
ggccaggctgctggctatgagctctgcggtgcgctgagccggcctccgtcgaagcagaac
acgccccagtacctggcctcacccctggaccaggaggtggtgccctgtacccctagccac
gtcggccggccgcgcctggagaagctgtctggcctagccgcacccgactacactaggctg
tccccggccaagattgtgctgaggcggcacctgagccaggaccacacggtgcccggcagg
ccggccgccagtgagctgcattcgagagctgagcacaccaaggagaacggccttccctac
cagagccccagcgtgcctggcagcatgaagctgagccctcaggacccgcggcccctgtcc
cctggggccttgcagcttgctggagagaagagcagtgagaagggcctgagagagcgcgcc
tatggcagcagcggggagctcatcaccagcctgcccatcagcatcccgctcagcaccgtg
cagcccaacaagctcccggtcagcattcccctggccagcgtggtgctgcccagccgcgcc
gagagggcgaggagcacccccagtcccgtgctgcagccccgtgacccctcgtccacactt
gaaaagcagattggtgctaatgcccacggtgctgggagcagaagccttgccctggccccc
gcaggcttctcctacgctggctcggtggccatcagcggggccttggcgggcagcccggcc
tctctcacacctggagccgagccggccaccttggatgagtcctccagctctgggagcctt
tttgccacggtggggtcccgcagctccacgccacagcaccccctgctgctggcacagccc
cggaactcgcttcctgcctctcccgcccaccagctctcctccagtccccggcttggtggg
gccacacagggcccgctgcccgaggccaccaagggggacctgccctccgattccggcttc
tcagatcctgagagtgaagccaagaggaggattgtgttcaccatcaccactggtgcgggc
agtgccaagcagtcgccctccagcaagcacagccccctgaccaccagcgcccgtggggac
tgtgtgccgagccacgggcaggacagccgcaagcgcggccggcggaagcgagcatctgcg
gggacgcccagcttgagcgcaggcgtgtcccccaagcgccgagccctgccgtccgtcgct
ggccttttcacacagccttcggggtctcccctcaacctcaactccatggtcagtaacatc
aaccagcccctggagattacagccatctcgtccccggagacctccctgaagagctcccct
gtgccctaccaggaccacgaccagccccccgtgctcaagaaggagcggcctctgagccag
accaatggggcacactactccccactcacctcagacgaggagccaggctctgaggacgag
cccagcagtgctcgaattgagagaaaaattgcaacaatctccttagaaagcaaatctccc
ccgaaaaccttggaaaacggtggtggcttggcgggaaggaagcccgcgcccgccggcgag
ccagtcaatagcagcaagtggaagtccaccttctcgcccatctccgacatcggcctggcc
aagtcggcggacagcccgctgcaggccagctccgccctcagccagaactccctgttcacg
ttccggcccgccctggaggagccctctgccgatgccaagctggccgctcaccccaggaaa
ggctttcccggctccctgtcgggggctgatggactcagcccgggcaccaaccctgccaac
ggctgcaccttcggcgggggcctggccgcggacctgagtttacacagcttcagtgatggt
gcttctcttccccacaagggccccgaggcggccggcctgagctccccgctgagcttcccc
tcgcagcgcggcaaggagggctcggacgccaaccctttcctgagcaagaggcagctggac
ggcctggctgggctgaagggcgagggcagccgcggcaaggaggcaggggagggcggccta
ccgctgtgcgggcccacggacaagaccccactgctgagcggcaaggccgccaaggcccgg
gaccgcgagctcgacctcaagaatggccacaacctcttcatctctgcggcggccgtgcct
cccggaagcctcctcagcggccccggcctggccccggcggcgtcgtccgcaggcggcgcg
gcgtcctccgcccagacgcaccggtccttcctgggccccttcccgccggggccgcagttc
gcgctcggccccatgtccctgcaggccaacctcggctccgtggccggctcctccgtgctg
cagtcgctgttcagctctgtgccggccgccgcaggcctggtgcacgtgtcgtccgctgcc
accagactgaccaactcgcacgccatgggcagcttttccggggtggcaggcggcacagtt
ggaggtgtctttaaccacgcggtgccttccgcctctgctcatccgtttggagcccgtgtc
ggccgcggggctgcatgtggcagcgccacactgggcccgagcccgctgcaggcggcggcc
agcgcctcggcctcttcctttcaggccccggcctcggttgagacccggccgcccccgccg
cctccgcctccgcctcccccgctgcccccgcctgcgcacctgggccggtcccccgcgggg
ccgcccgtcctccacgccccccctccacctaacgccgccttgcctcctcccccaacgctg
ctggcctctaaccctgagcccgcgcttctgcagagcctcgcgtccctcccgcctaaccaa
gctttcttgccccccacctctgctgcctctctgccgcctgctaacgcctctttgtctatc
aagctcacctccctcccgcacaagggcgcccgcccctccttcacggtgcaccaccagccc
ctgccccggctggccctggcccaggccgcgcccgggatcccacaggccagcgccacgggg
ccgtccgcggtgtgggtgtccctcggcatgccgcctccctatgccgcgcacctttcgggg
gttaagccgcgataa
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