KEGG   Puma yagouaroundi (jaguarundi): 121041863
Entry
121041863         CDS       T07555                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
pyu  Puma yagouaroundi (jaguarundi)
Pathway
pyu01521  EGFR tyrosine kinase inhibitor resistance
pyu01522  Endocrine resistance
pyu04010  MAPK signaling pathway
pyu04012  ErbB signaling pathway
pyu04014  Ras signaling pathway
pyu04015  Rap1 signaling pathway
pyu04022  cGMP-PKG signaling pathway
pyu04024  cAMP signaling pathway
pyu04062  Chemokine signaling pathway
pyu04066  HIF-1 signaling pathway
pyu04068  FoxO signaling pathway
pyu04071  Sphingolipid signaling pathway
pyu04072  Phospholipase D signaling pathway
pyu04114  Oocyte meiosis
pyu04140  Autophagy - animal
pyu04148  Efferocytosis
pyu04150  mTOR signaling pathway
pyu04151  PI3K-Akt signaling pathway
pyu04210  Apoptosis
pyu04218  Cellular senescence
pyu04270  Vascular smooth muscle contraction
pyu04370  VEGF signaling pathway
pyu04371  Apelin signaling pathway
pyu04380  Osteoclast differentiation
pyu04510  Focal adhesion
pyu04540  Gap junction
pyu04550  Signaling pathways regulating pluripotency of stem cells
pyu04613  Neutrophil extracellular trap formation
pyu04620  Toll-like receptor signaling pathway
pyu04650  Natural killer cell mediated cytotoxicity
pyu04660  T cell receptor signaling pathway
pyu04662  B cell receptor signaling pathway
pyu04664  Fc epsilon RI signaling pathway
pyu04666  Fc gamma R-mediated phagocytosis
pyu04668  TNF signaling pathway
pyu04720  Long-term potentiation
pyu04722  Neurotrophin signaling pathway
pyu04725  Cholinergic synapse
pyu04726  Serotonergic synapse
pyu04730  Long-term depression
pyu04810  Regulation of actin cytoskeleton
pyu04910  Insulin signaling pathway
pyu04912  GnRH signaling pathway
pyu04914  Progesterone-mediated oocyte maturation
pyu04915  Estrogen signaling pathway
pyu04916  Melanogenesis
pyu04917  Prolactin signaling pathway
pyu04919  Thyroid hormone signaling pathway
pyu04921  Oxytocin signaling pathway
pyu04926  Relaxin signaling pathway
pyu04928  Parathyroid hormone synthesis, secretion and action
pyu04929  GnRH secretion
pyu04934  Cushing syndrome
pyu04935  Growth hormone synthesis, secretion and action
pyu05010  Alzheimer disease
pyu05022  Pathways of neurodegeneration - multiple diseases
pyu05034  Alcoholism
pyu05132  Salmonella infection
pyu05135  Yersinia infection
pyu05160  Hepatitis C
pyu05161  Hepatitis B
pyu05163  Human cytomegalovirus infection
pyu05164  Influenza A
pyu05165  Human papillomavirus infection
pyu05166  Human T-cell leukemia virus 1 infection
pyu05167  Kaposi sarcoma-associated herpesvirus infection
pyu05170  Human immunodeficiency virus 1 infection
pyu05200  Pathways in cancer
pyu05205  Proteoglycans in cancer
pyu05206  MicroRNAs in cancer
pyu05207  Chemical carcinogenesis - receptor activation
pyu05208  Chemical carcinogenesis - reactive oxygen species
pyu05210  Colorectal cancer
pyu05211  Renal cell carcinoma
pyu05212  Pancreatic cancer
pyu05213  Endometrial cancer
pyu05214  Glioma
pyu05215  Prostate cancer
pyu05216  Thyroid cancer
pyu05218  Melanoma
pyu05219  Bladder cancer
pyu05220  Chronic myeloid leukemia
pyu05221  Acute myeloid leukemia
pyu05223  Non-small cell lung cancer
pyu05224  Breast cancer
pyu05225  Hepatocellular carcinoma
pyu05226  Gastric cancer
pyu05230  Central carbon metabolism in cancer
pyu05231  Choline metabolism in cancer
pyu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pyu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    121041863 (MAP2K1)
   04012 ErbB signaling pathway
    121041863 (MAP2K1)
   04014 Ras signaling pathway
    121041863 (MAP2K1)
   04015 Rap1 signaling pathway
    121041863 (MAP2K1)
   04370 VEGF signaling pathway
    121041863 (MAP2K1)
   04371 Apelin signaling pathway
    121041863 (MAP2K1)
   04668 TNF signaling pathway
    121041863 (MAP2K1)
   04066 HIF-1 signaling pathway
    121041863 (MAP2K1)
   04068 FoxO signaling pathway
    121041863 (MAP2K1)
   04072 Phospholipase D signaling pathway
    121041863 (MAP2K1)
   04071 Sphingolipid signaling pathway
    121041863 (MAP2K1)
   04024 cAMP signaling pathway
    121041863 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    121041863 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    121041863 (MAP2K1)
   04150 mTOR signaling pathway
    121041863 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    121041863 (MAP2K1)
   04148 Efferocytosis
    121041863 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    121041863 (MAP2K1)
   04210 Apoptosis
    121041863 (MAP2K1)
   04218 Cellular senescence
    121041863 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    121041863 (MAP2K1)
   04540 Gap junction
    121041863 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    121041863 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    121041863 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    121041863 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    121041863 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    121041863 (MAP2K1)
   04660 T cell receptor signaling pathway
    121041863 (MAP2K1)
   04662 B cell receptor signaling pathway
    121041863 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    121041863 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    121041863 (MAP2K1)
   04062 Chemokine signaling pathway
    121041863 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    121041863 (MAP2K1)
   04929 GnRH secretion
    121041863 (MAP2K1)
   04912 GnRH signaling pathway
    121041863 (MAP2K1)
   04915 Estrogen signaling pathway
    121041863 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    121041863 (MAP2K1)
   04917 Prolactin signaling pathway
    121041863 (MAP2K1)
   04921 Oxytocin signaling pathway
    121041863 (MAP2K1)
   04926 Relaxin signaling pathway
    121041863 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    121041863 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    121041863 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    121041863 (MAP2K1)
   04916 Melanogenesis
    121041863 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    121041863 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    121041863 (MAP2K1)
   04726 Serotonergic synapse
    121041863 (MAP2K1)
   04720 Long-term potentiation
    121041863 (MAP2K1)
   04730 Long-term depression
    121041863 (MAP2K1)
   04722 Neurotrophin signaling pathway
    121041863 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    121041863 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    121041863 (MAP2K1)
   05206 MicroRNAs in cancer
    121041863 (MAP2K1)
   05205 Proteoglycans in cancer
    121041863 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    121041863 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    121041863 (MAP2K1)
   05230 Central carbon metabolism in cancer
    121041863 (MAP2K1)
   05231 Choline metabolism in cancer
    121041863 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    121041863 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    121041863 (MAP2K1)
   05212 Pancreatic cancer
    121041863 (MAP2K1)
   05225 Hepatocellular carcinoma
    121041863 (MAP2K1)
   05226 Gastric cancer
    121041863 (MAP2K1)
   05214 Glioma
    121041863 (MAP2K1)
   05216 Thyroid cancer
    121041863 (MAP2K1)
   05221 Acute myeloid leukemia
    121041863 (MAP2K1)
   05220 Chronic myeloid leukemia
    121041863 (MAP2K1)
   05218 Melanoma
    121041863 (MAP2K1)
   05211 Renal cell carcinoma
    121041863 (MAP2K1)
   05219 Bladder cancer
    121041863 (MAP2K1)
   05215 Prostate cancer
    121041863 (MAP2K1)
   05213 Endometrial cancer
    121041863 (MAP2K1)
   05224 Breast cancer
    121041863 (MAP2K1)
   05223 Non-small cell lung cancer
    121041863 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    121041863 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    121041863 (MAP2K1)
   05161 Hepatitis B
    121041863 (MAP2K1)
   05160 Hepatitis C
    121041863 (MAP2K1)
   05164 Influenza A
    121041863 (MAP2K1)
   05163 Human cytomegalovirus infection
    121041863 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    121041863 (MAP2K1)
   05165 Human papillomavirus infection
    121041863 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    121041863 (MAP2K1)
   05135 Yersinia infection
    121041863 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    121041863 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    121041863 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    121041863 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    121041863 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    121041863 (MAP2K1)
   01522 Endocrine resistance
    121041863 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pyu01001]
    121041863 (MAP2K1)
Enzymes [BR:pyu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     121041863 (MAP2K1)
Protein kinases [BR:pyu01001]
 Serine/threonine kinases: STE group
  STE7 family
   121041863 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Seadorna_VP7 Haspin_kinase
Other DBs
NCBI-GeneID: 121041863
NCBI-ProteinID: XP_040348973
LinkDB
Position
Unknown
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDGEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagctcgatgagcagcaacggaagcgcctggaggcctttcttacccagaagcagaaggtc
ggggaattgaaggatgacgacttcgagaagatcagcgagctgggcgccggcaacggtggt
gtggtgttcaaggtctcccataagccgtctggcctggtcatggccagaaagctaattcac
ctggagatcaaacctgcaatccggaaccagatcataagggagctgcaggttctacatgag
tgcaactccccatacatcgtgggcttctatggcgcgttctacagcgacggcgagatcagt
atctgtatggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggtctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccttccaacatcctagtgaactct
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tccgtgcagtcggacatctggagcatggggctgtctctggttgagatggcagtcgggagg
tatcccatccctcctcccgatgccaaggagctggagctgctgtttgggtgccaagtggag
ggagatgcggctgagacgccacccaggccgaggacccctggaaggcccctcagctcgtat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgag
cctcctccaaagctgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcctcataaaaaacccagcagagagagcagatctgaaacaactcatggttcatgccttt
atcaagagatctgatggtgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagtacaccgacccacgcggccggcgtctaa

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