Puma yagouaroundi (jaguarundi): 121041863
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Entry
121041863 CDS
T07555
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
KO
K04368
mitogen-activated protein kinase kinase 1 [EC:
2.7.12.2
]
Organism
pyu
Puma yagouaroundi (jaguarundi)
Pathway
pyu01521
EGFR tyrosine kinase inhibitor resistance
pyu01522
Endocrine resistance
pyu04010
MAPK signaling pathway
pyu04012
ErbB signaling pathway
pyu04014
Ras signaling pathway
pyu04015
Rap1 signaling pathway
pyu04022
cGMP-PKG signaling pathway
pyu04024
cAMP signaling pathway
pyu04062
Chemokine signaling pathway
pyu04066
HIF-1 signaling pathway
pyu04068
FoxO signaling pathway
pyu04071
Sphingolipid signaling pathway
pyu04072
Phospholipase D signaling pathway
pyu04114
Oocyte meiosis
pyu04140
Autophagy - animal
pyu04148
Efferocytosis
pyu04150
mTOR signaling pathway
pyu04151
PI3K-Akt signaling pathway
pyu04210
Apoptosis
pyu04218
Cellular senescence
pyu04270
Vascular smooth muscle contraction
pyu04370
VEGF signaling pathway
pyu04371
Apelin signaling pathway
pyu04380
Osteoclast differentiation
pyu04510
Focal adhesion
pyu04540
Gap junction
pyu04550
Signaling pathways regulating pluripotency of stem cells
pyu04613
Neutrophil extracellular trap formation
pyu04620
Toll-like receptor signaling pathway
pyu04650
Natural killer cell mediated cytotoxicity
pyu04660
T cell receptor signaling pathway
pyu04662
B cell receptor signaling pathway
pyu04664
Fc epsilon RI signaling pathway
pyu04666
Fc gamma R-mediated phagocytosis
pyu04668
TNF signaling pathway
pyu04720
Long-term potentiation
pyu04722
Neurotrophin signaling pathway
pyu04725
Cholinergic synapse
pyu04726
Serotonergic synapse
pyu04730
Long-term depression
pyu04810
Regulation of actin cytoskeleton
pyu04910
Insulin signaling pathway
pyu04912
GnRH signaling pathway
pyu04914
Progesterone-mediated oocyte maturation
pyu04915
Estrogen signaling pathway
pyu04916
Melanogenesis
pyu04917
Prolactin signaling pathway
pyu04919
Thyroid hormone signaling pathway
pyu04921
Oxytocin signaling pathway
pyu04926
Relaxin signaling pathway
pyu04928
Parathyroid hormone synthesis, secretion and action
pyu04929
GnRH secretion
pyu04934
Cushing syndrome
pyu04935
Growth hormone synthesis, secretion and action
pyu05010
Alzheimer disease
pyu05022
Pathways of neurodegeneration - multiple diseases
pyu05034
Alcoholism
pyu05132
Salmonella infection
pyu05135
Yersinia infection
pyu05160
Hepatitis C
pyu05161
Hepatitis B
pyu05163
Human cytomegalovirus infection
pyu05164
Influenza A
pyu05165
Human papillomavirus infection
pyu05166
Human T-cell leukemia virus 1 infection
pyu05167
Kaposi sarcoma-associated herpesvirus infection
pyu05170
Human immunodeficiency virus 1 infection
pyu05200
Pathways in cancer
pyu05205
Proteoglycans in cancer
pyu05206
MicroRNAs in cancer
pyu05207
Chemical carcinogenesis - receptor activation
pyu05208
Chemical carcinogenesis - reactive oxygen species
pyu05210
Colorectal cancer
pyu05211
Renal cell carcinoma
pyu05212
Pancreatic cancer
pyu05213
Endometrial cancer
pyu05214
Glioma
pyu05215
Prostate cancer
pyu05216
Thyroid cancer
pyu05218
Melanoma
pyu05219
Bladder cancer
pyu05220
Chronic myeloid leukemia
pyu05221
Acute myeloid leukemia
pyu05223
Non-small cell lung cancer
pyu05224
Breast cancer
pyu05225
Hepatocellular carcinoma
pyu05226
Gastric cancer
pyu05230
Central carbon metabolism in cancer
pyu05231
Choline metabolism in cancer
pyu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
pyu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
121041863 (MAP2K1)
04012 ErbB signaling pathway
121041863 (MAP2K1)
04014 Ras signaling pathway
121041863 (MAP2K1)
04015 Rap1 signaling pathway
121041863 (MAP2K1)
04370 VEGF signaling pathway
121041863 (MAP2K1)
04371 Apelin signaling pathway
121041863 (MAP2K1)
04668 TNF signaling pathway
121041863 (MAP2K1)
04066 HIF-1 signaling pathway
121041863 (MAP2K1)
04068 FoxO signaling pathway
121041863 (MAP2K1)
04072 Phospholipase D signaling pathway
121041863 (MAP2K1)
04071 Sphingolipid signaling pathway
121041863 (MAP2K1)
04024 cAMP signaling pathway
121041863 (MAP2K1)
04022 cGMP-PKG signaling pathway
121041863 (MAP2K1)
04151 PI3K-Akt signaling pathway
121041863 (MAP2K1)
04150 mTOR signaling pathway
121041863 (MAP2K1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
121041863 (MAP2K1)
04148 Efferocytosis
121041863 (MAP2K1)
09143 Cell growth and death
04114 Oocyte meiosis
121041863 (MAP2K1)
04210 Apoptosis
121041863 (MAP2K1)
04218 Cellular senescence
121041863 (MAP2K1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
121041863 (MAP2K1)
04540 Gap junction
121041863 (MAP2K1)
04550 Signaling pathways regulating pluripotency of stem cells
121041863 (MAP2K1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
121041863 (MAP2K1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
121041863 (MAP2K1)
04620 Toll-like receptor signaling pathway
121041863 (MAP2K1)
04650 Natural killer cell mediated cytotoxicity
121041863 (MAP2K1)
04660 T cell receptor signaling pathway
121041863 (MAP2K1)
04662 B cell receptor signaling pathway
121041863 (MAP2K1)
04664 Fc epsilon RI signaling pathway
121041863 (MAP2K1)
04666 Fc gamma R-mediated phagocytosis
121041863 (MAP2K1)
04062 Chemokine signaling pathway
121041863 (MAP2K1)
09152 Endocrine system
04910 Insulin signaling pathway
121041863 (MAP2K1)
04929 GnRH secretion
121041863 (MAP2K1)
04912 GnRH signaling pathway
121041863 (MAP2K1)
04915 Estrogen signaling pathway
121041863 (MAP2K1)
04914 Progesterone-mediated oocyte maturation
121041863 (MAP2K1)
04917 Prolactin signaling pathway
121041863 (MAP2K1)
04921 Oxytocin signaling pathway
121041863 (MAP2K1)
04926 Relaxin signaling pathway
121041863 (MAP2K1)
04935 Growth hormone synthesis, secretion and action
121041863 (MAP2K1)
04919 Thyroid hormone signaling pathway
121041863 (MAP2K1)
04928 Parathyroid hormone synthesis, secretion and action
121041863 (MAP2K1)
04916 Melanogenesis
121041863 (MAP2K1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
121041863 (MAP2K1)
09156 Nervous system
04725 Cholinergic synapse
121041863 (MAP2K1)
04726 Serotonergic synapse
121041863 (MAP2K1)
04720 Long-term potentiation
121041863 (MAP2K1)
04730 Long-term depression
121041863 (MAP2K1)
04722 Neurotrophin signaling pathway
121041863 (MAP2K1)
09158 Development and regeneration
04380 Osteoclast differentiation
121041863 (MAP2K1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
121041863 (MAP2K1)
05206 MicroRNAs in cancer
121041863 (MAP2K1)
05205 Proteoglycans in cancer
121041863 (MAP2K1)
05207 Chemical carcinogenesis - receptor activation
121041863 (MAP2K1)
05208 Chemical carcinogenesis - reactive oxygen species
121041863 (MAP2K1)
05230 Central carbon metabolism in cancer
121041863 (MAP2K1)
05231 Choline metabolism in cancer
121041863 (MAP2K1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
121041863 (MAP2K1)
09162 Cancer: specific types
05210 Colorectal cancer
121041863 (MAP2K1)
05212 Pancreatic cancer
121041863 (MAP2K1)
05225 Hepatocellular carcinoma
121041863 (MAP2K1)
05226 Gastric cancer
121041863 (MAP2K1)
05214 Glioma
121041863 (MAP2K1)
05216 Thyroid cancer
121041863 (MAP2K1)
05221 Acute myeloid leukemia
121041863 (MAP2K1)
05220 Chronic myeloid leukemia
121041863 (MAP2K1)
05218 Melanoma
121041863 (MAP2K1)
05211 Renal cell carcinoma
121041863 (MAP2K1)
05219 Bladder cancer
121041863 (MAP2K1)
05215 Prostate cancer
121041863 (MAP2K1)
05213 Endometrial cancer
121041863 (MAP2K1)
05224 Breast cancer
121041863 (MAP2K1)
05223 Non-small cell lung cancer
121041863 (MAP2K1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
121041863 (MAP2K1)
05170 Human immunodeficiency virus 1 infection
121041863 (MAP2K1)
05161 Hepatitis B
121041863 (MAP2K1)
05160 Hepatitis C
121041863 (MAP2K1)
05164 Influenza A
121041863 (MAP2K1)
05163 Human cytomegalovirus infection
121041863 (MAP2K1)
05167 Kaposi sarcoma-associated herpesvirus infection
121041863 (MAP2K1)
05165 Human papillomavirus infection
121041863 (MAP2K1)
09171 Infectious disease: bacterial
05132 Salmonella infection
121041863 (MAP2K1)
05135 Yersinia infection
121041863 (MAP2K1)
09164 Neurodegenerative disease
05010 Alzheimer disease
121041863 (MAP2K1)
05022 Pathways of neurodegeneration - multiple diseases
121041863 (MAP2K1)
09165 Substance dependence
05034 Alcoholism
121041863 (MAP2K1)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
121041863 (MAP2K1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
121041863 (MAP2K1)
01522 Endocrine resistance
121041863 (MAP2K1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
pyu01001
]
121041863 (MAP2K1)
Enzymes [BR:
pyu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
121041863 (MAP2K1)
Protein kinases [BR:
pyu01001
]
Serine/threonine kinases: STE group
STE7 family
121041863 (MAP2K1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Seadorna_VP7
Haspin_kinase
Motif
Other DBs
NCBI-GeneID:
121041863
NCBI-ProteinID:
XP_040348973
LinkDB
All DBs
Position
Unknown
AA seq
393 aa
AA seq
DB search
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDGEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq
1182 nt
NT seq
+upstream
nt +downstream
nt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagctcgatgagcagcaacggaagcgcctggaggcctttcttacccagaagcagaaggtc
ggggaattgaaggatgacgacttcgagaagatcagcgagctgggcgccggcaacggtggt
gtggtgttcaaggtctcccataagccgtctggcctggtcatggccagaaagctaattcac
ctggagatcaaacctgcaatccggaaccagatcataagggagctgcaggttctacatgag
tgcaactccccatacatcgtgggcttctatggcgcgttctacagcgacggcgagatcagt
atctgtatggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggtctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccttccaacatcctagtgaactct
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tccgtgcagtcggacatctggagcatggggctgtctctggttgagatggcagtcgggagg
tatcccatccctcctcccgatgccaaggagctggagctgctgtttgggtgccaagtggag
ggagatgcggctgagacgccacccaggccgaggacccctggaaggcccctcagctcgtat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgag
cctcctccaaagctgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcctcataaaaaacccagcagagagagcagatctgaaacaactcatggttcatgccttt
atcaagagatctgatggtgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagtacaccgacccacgcggccggcgtctaa
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integrated database retrieval system