KEGG   PATHWAY: reu00362
Entry
reu00362                    Pathway                                
Name
Benzoate degradation - Cupriavidus pinatubonensis JMP134
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
reu00362  Benzoate degradation
reu00362

Module
reu_M00548  Benzene degradation, benzene => catechol [PATH:reu00362]
reu_M00551  Benzoate degradation, benzoate => catechol / methylbenzoate => methylcatechol [PATH:reu00362]
reu_M00568  Catechol ortho-cleavage, catechol => 3-oxoadipate [PATH:reu00362]
reu_M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA [PATH:reu00362]
Other DBs
UMBBD: benz2 benz abs
GO: 0043639
Organism
Cupriavidus pinatubonensis JMP134 [GN:reu]
Gene
Reut_B4403  benzoate 1,2-dioxygenase, alpha subunit [KO:K05549] [EC:1.14.12.10 1.14.12.-]
Reut_B4404  benzoate 1,2-dioxygenase, beta subunit [KO:K05550] [EC:1.14.12.10 1.14.12.-]
Reut_B4405  Ferredoxin:Oxidoreductase FAD/NAD(P)-binding:Oxidoreductase FAD-binding region [KO:K05784] [EC:1.18.1.-]
Reut_B4406  1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase [KO:K05783] [EC:1.3.1.25 1.3.1.-]
Reut_B4402  Catechol dioxygenase, N-terminal [KO:K03381] [EC:1.13.11.1]
Reut_A1705  Catechol dioxygenase, N-terminal [KO:K03381] [EC:1.13.11.1]
Reut_B4400  muconate cycloisomerase [KO:K01856] [EC:5.5.1.1]
Reut_A1689  muconate cycloisomerase [KO:K01856] [EC:5.5.1.1]
Reut_A1502  muconolactone delta-isomerase [KO:K03464] [EC:5.3.3.4]
Reut_A1690  muconolactone delta-isomerase [KO:K03464] [EC:5.3.3.4]
Reut_A0115  3-oxoadipate enol-lactonase [KO:K01055] [EC:3.1.1.24]
Reut_A1692  3-oxoadipate enol-lactonase [KO:K01055] [EC:3.1.1.24]
Reut_B5022  3-oxoadipate enol-lactonase [KO:K14727] [EC:3.1.1.24 4.1.1.44]
Reut_A1506  3-oxoadipate CoA-transferase alpha subunit [KO:K01031] [EC:2.8.3.6]
Reut_B5585  3-oxoadipate CoA-transferase alpha subunit [KO:K01031] [EC:2.8.3.6]
Reut_B5586  3-oxoadipate CoA-transferase beta subunit [KO:K01032] [EC:2.8.3.6]
Reut_A1505  butyryl-CoA:acetate CoA transferase [KO:K01032] [EC:2.8.3.6]
Reut_A1669  Thiolase [KO:K00632] [EC:2.3.1.16]
Reut_A0448  Thiolase [KO:K00632] [EC:2.3.1.16]
Reut_B5587  3-oxoadipyl-CoA thiolase [KO:K07823] [EC:2.3.1.174]
Reut_A1699  phenol 2-monooxygenase P0 subunit [KO:K16249]
Reut_B5680  phenol 2-monooxygenase P0 subunit [KO:K16249]
Reut_B5681  phenol 2-monooxygenase P1 subunit [KO:K16243] [EC:1.14.13.244 1.14.13.243]
Reut_A1700  phenol 2-monooxygenase P1 subunit [KO:K16243] [EC:1.14.13.244 1.14.13.243]
Reut_A1701  phenol 2-monooxygenase P2 subunit [KO:K16244] [EC:1.14.13.244 1.14.13.243]
Reut_B5682  phenol 2-monooxygenase P2 subunit [KO:K16244] [EC:1.14.13.244 1.14.13.243]
Reut_B5683  phenol 2-monooxygenase P3 subunit [KO:K16242] [EC:1.14.13.244 1.14.13.243]
Reut_A1702  phenol 2-monooxygenase P3 subunit [KO:K16242] [EC:1.14.13.244 1.14.13.243]
Reut_A1703  phenol 2-monooxygenase P4 subunit [KO:K16245] [EC:1.14.13.244 1.14.13.243]
Reut_B5684  phenol 2-monooxygenase P4 subunit [KO:K16245] [EC:1.14.13.244 1.14.13.243]
Reut_A1704  phenol 2-monooxygenase P5 subunit [KO:K16246] [EC:1.14.13.244 1.14.13.243]
Reut_B5685  phenol 2-monooxygenase P5 subunit [KO:K16246] [EC:1.14.13.244 1.14.13.243]
Reut_B3785  Amidohydrolase 2 [KO:K14333] [EC:4.1.1.46]
Reut_B5687  catechol 2,3-dioxygenase [KO:K00446] [EC:1.13.11.2]
Reut_B5690  2-hydroxymuconate semialdehyde hydrolase [KO:K10216] [EC:3.7.1.9]
Reut_A0272  4-oxalocrotonate decarboxylase [KO:K02554] [EC:4.2.1.80]
Reut_B5220  2-keto-4-pentenoate hydratase [KO:K02554] [EC:4.2.1.80]
Reut_B5499  4-oxalocrotonate decarboxylase [KO:K02554] [EC:4.2.1.80]
Reut_B5145  putative hydratase [KO:K02554] [EC:4.2.1.80]
Reut_A1510  4-oxalocrotonate decarboxylase [KO:K18364] [EC:4.2.1.80 4.2.1.132]
Reut_B5691  4-oxalocrotonate decarboxylase [KO:K18364] [EC:4.2.1.80 4.2.1.132]
Reut_B5823  4-hydroxy-2-oxovalerate aldolase [KO:K01666] [EC:4.1.3.39]
Reut_B5824  acetaldehyde dehydrogenase [KO:K04073] [EC:1.2.1.10]
Reut_B5498  Aldehyde dehydrogenase [KO:K10217] [EC:1.2.1.32 1.2.1.85]
Reut_B5689  2-hydroxymuconate semialdehyde dehydrogenase [KO:K10217] [EC:1.2.1.32 1.2.1.85]
Reut_A0855  4-oxalocrotonate tautomerase [KO:K01821] [EC:5.3.2.6]
Reut_B5693  4-oxalocrotonate isomerase [KO:K01821] [EC:5.3.2.6]
Reut_A2880  4-oxalocrotonate tautomerase [KO:K01821] [EC:5.3.2.6]
Reut_A0858  4-oxalocrotonate tautomerase [KO:K01821] [EC:5.3.2.6]
Reut_B5692  4-oxalocrotonate decarboxylase [KO:K01617] [EC:4.1.1.77]
Reut_B5500  4-oxalocrotonate decarboxylase [KO:K01617] [EC:4.1.1.77]
Reut_B4137  hydroxyquinol 1,2-dioxygenase [KO:K04098] [EC:1.13.11.37]
Reut_A1587  catechol 1,2-dioxygenase [KO:K04098] [EC:1.13.11.37]
Reut_D6463  Iron-containing alcohol dehydrogenase [KO:K00217] [EC:1.3.1.32]
Reut_D6471  Iron-containing alcohol dehydrogenase [KO:K00217] [EC:1.3.1.32]
Reut_B4694  maleylacetate reductase [KO:K00217] [EC:1.3.1.32]
Reut_B4129  maleylacetate reductase [KO:K00217] [EC:1.3.1.32]
Reut_A1589  maleylacetate reductase [KO:K00217] [EC:1.3.1.32]
Reut_B5024  protocatechuate 3,4-dioxygenase, alpha subunit [KO:K00448] [EC:1.13.11.3]
Reut_B5025  protocatechuate 3,4-dioxygenase, beta subunit [KO:K00449] [EC:1.13.11.3]
Reut_B5023  3-carboxy-cis,cis-muconate cycloisomerase [KO:K01857] [EC:5.5.1.2]
Reut_A0521  Carboxymuconolactone decarboxylase [KO:K01607] [EC:4.1.1.44]
Reut_B5696  Carboxymuconolactone decarboxylase [KO:K01607] [EC:4.1.1.44]
Reut_C5930  Amidohydrolase 2 [KO:K10221] [EC:3.1.1.57]
Reut_B4794  4-oxalomesaconate hydratase [KO:K10220] [EC:4.2.1.83]
Reut_B4781  4-carboxy-4-hydroxy-2-oxoadipate aldolase [KO:K10218] [EC:4.1.3.17]
Reut_B5772  Dimethylmenaquinone methyltransferase [KO:K10218] [EC:4.1.3.17]
Reut_B4616  Dimethylmenaquinone methyltransferase [KO:K10218] [EC:4.1.3.17]
Reut_B4782  Dimethylmenaquinone methyltransferase [KO:K10218] [EC:4.1.3.17]
Reut_B4783  Dimethylmenaquinone methyltransferase [KO:K10218] [EC:4.1.3.17]
Reut_B5773  Dimethylmenaquinone methyltransferase [KO:K10218] [EC:4.1.3.17]
Reut_B4006  Aromatic-ring hydroxylase [KO:K00481] [EC:1.14.13.2]
Reut_B5020  Aromatic-ring hydroxylase [KO:K00481] [EC:1.14.13.2]
Reut_B5861  3-hydroxybenzoate 6-hydroxylase [KO:K22270] [EC:1.14.13.24]
Reut_B5805  3-hydroxybenzoate 6-hydroxylase [KO:K22270] [EC:1.14.13.24]
Reut_A2179  Thioesterase superfamily [KO:K01075] [EC:3.1.2.23]
Reut_A1327  benzoate-CoA ligase [KO:K04110] [EC:6.2.1.25]
Reut_B3918  AMP-dependent synthetase and ligase [KO:K04116] [EC:6.2.1.-]
Reut_B3917  Acyl-CoA dehydrogenase, C-terminal:Acyl-CoA dehydrogenase, central region:Acyl-CoA dehydrogenase, N-terminal [KO:K04117] [EC:1.3.99.-]
Reut_B3915  2-hydroxycyclohexane-1-carbonyl-CoA dehydrogenase [KO:K07535] [EC:1.1.1.-]
Reut_C6108  Short-chain dehydrogenase/reductase SDR [KO:K07535] [EC:1.1.1.-]
Reut_A1828  Short-chain dehydrogenase/reductase SDR [KO:K07535] [EC:1.1.1.-]
Reut_B3916  1,4-Dihydroxy-2-naphthoate synthase [KO:K07536] [EC:3.1.2.-]
Reut_C6107  1,4-Dihydroxy-2-naphthoate synthase [KO:K07536] [EC:3.1.2.-]
Reut_B4559  Acyl-CoA dehydrogenase, C-terminal:Acyl-CoA dehydrogenase, central region [KO:K04118] [EC:1.3.1.62]
Reut_B3873  3-hydroxyacyl-CoA dehydrogenase [KO:K07516] [EC:1.1.1.35]
Reut_A1405  3-hydroxyacyl-CoA dehydrogenase [KO:K07516] [EC:1.1.1.35]
Reut_A0447  3-hydroxyacyl-CoA dehydrogenase [KO:K07516] [EC:1.1.1.35]
Reut_B4799  3-hydroxyacyl-CoA dehydrogenase [KO:K07516] [EC:1.1.1.35]
Reut_A0805  Acyl-CoA dehydrogenase, C-terminal:Acyl-CoA dehydrogenase, central region:Acyl-CoA dehydrogenase, N-terminal [KO:K00252] [EC:1.3.8.6]
Reut_A3010  short chain enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
Reut_A1010  3-hydroxyacyl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
Reut_C6369  3-hydroxyacyl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
Reut_A0255  3-hydroxyacyl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
Reut_B3956  3-hydroxyacyl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
Reut_C6280  3-hydroxyacyl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
Reut_A0138  Thiolase [KO:K00626] [EC:2.3.1.9]
Reut_A1348  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
Reut_A1407  Thiolase [KO:K00626] [EC:2.3.1.9]
Reut_A1565  Thiolase [KO:K00626] [EC:2.3.1.9]
Reut_B3611  Thiolase [KO:K00626] [EC:2.3.1.9]
Reut_B3829  acetyl-CoA acetyltransferase (thiolase) [KO:K00626] [EC:2.3.1.9]
Reut_B4152  acetyl-CoA acetyltransferase (thiolase) [KO:K00626] [EC:2.3.1.9]
Reut_C5943  Thiolase [KO:K00626] [EC:2.3.1.9]
Reut_C6062  Thiolase [KO:K00626] [EC:2.3.1.9]
Reut_B4561  Thiolase [KO:K00626] [EC:2.3.1.9]
Reut_B4565  acetyl-CoA acetyltransferase (thiolase) [KO:K00626] [EC:2.3.1.9]
Reut_B4738  Thiolase [KO:K00626] [EC:2.3.1.9]
Reut_B4787  acetyl-CoA acetyltransferase (thiolase) [KO:K00626] [EC:2.3.1.9]
Reut_A1353  3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
Reut_A1572  Thiolase [KO:K00626] [EC:2.3.1.9]
Reut_A1323  benzoyl-CoA oxygenase, component A [KO:K15511] [EC:1.14.13.208]
Reut_A1324  benzoyl-CoA oxygenase, component B [KO:K15512] [EC:1.14.13.208]
Reut_A1325  2,3-dihydro-2,3-dihydroxybenzoyl-CoA ring cleavage enzyme [KO:K15513] [EC:4.1.2.44]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00036  Oxaloacetate
C00084  Acetaldehyde
C00090  Catechol
C00091  Succinyl-CoA
C00146  Phenol
C00156  4-Hydroxybenzoate
C00180  Benzoate
C00196  2,3-Dihydroxybenzoate
C00230  3,4-Dihydroxybenzoate
C00332  Acetoacetyl-CoA
C00512  Benzoyl-CoA
C00527  Glutaryl-CoA
C00530  Hydroquinone
C00587  3-Hydroxybenzoate
C00596  2-Hydroxy-2,4-pentadienoate
C00628  2,5-Dihydroxybenzoate
C00682  2-Hydroxymuconate semialdehyde
C00846  3-Oxoadipate
C00877  Crotonoyl-CoA
C01063  Pimeloyl-CoA
C01144  (S)-3-Hydroxybutanoyl-CoA
C01163  3-Carboxy-cis,cis-muconate
C01278  2-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C01407  Benzene
C01751  Resorcinol
C02222  2-Maleylacetate
C02232  3-Oxoadipyl-CoA
C02411  Glutaconyl-1-CoA
C02480  cis,cis-Muconate
C02501  2-Hydroxymuconate
C02519  4-Methoxybenzoate
C02814  Benzene-1,2,4-triol
C02949  4-Hydroxybenzoyl-CoA
C03453  gamma-Oxalocrotonate
C03586  2-Oxo-2,3-dihydrofuran-5-acetate
C03589  4-Hydroxy-2-oxopentanoate
C03671  2-Pyrone-4,6-dicarboxylate
C03676  3-Hydroxy-cis,cis-muconate
C04091  cis-1,2-Dihydrobenzene-1,2-diol
C04115  4-Carboxy-4-hydroxy-2-oxoadipate
C04324  (1E,3E)-4-Hydroxybuta-1,3-diene-1,2,4-tricarboxylate
C04434  (1E)-4-Oxobut-1-ene-1,2,4-tricarboxylate
C04480  3-Carboxy-2-hydroxymuconate semialdehyde
C04484  4-Carboxy-2-hydroxymuconate semialdehyde
C04553  3-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C05375  2-Hydroxy-2-hydropyrone-4,6-dicarboxylate
C06033  Parapyruvate
C06035  4-Methylene-2-oxoglutarate
C06321  (1R,6S)-1,6-Dihydroxycyclohexa-2,4-diene-1-carboxylate
C06322  Cyclohexa-1,5-diene-1-carbonyl-CoA
C06333  2-Aminobenzenesulfonate
C06336  3-Sulfocatechol
C06714  3-Hydroxypimeloyl-CoA
C06715  3-Oxopimeloyl-CoA
C06723  6-Carboxyhex-2-enoyl-CoA
C06749  6-Hydroxycyclohex-1-ene-1-carbonyl-CoA
C09809  Cyclohexa-2,5-diene-1-carbonyl-CoA
C09810  Cyclohexa-1,4-diene-1-carbonyl-CoA
C09811  Cyclohex-1-ene-1-carbonyl-CoA
C09812  2-Hydroxycyclohexane-1-carbonyl-CoA
C09813  2-Oxocyclohexane-1-carbonyl-CoA
C09821  6-Oxocyclohex-1-ene-1-carbonyl-CoA
C09822  Cyclohexane-1-carboxylate
C09823  Cyclohexane-1-carbonyl-CoA
C14144  5-Carboxy-2-pentenoyl-CoA
C14610  (S)-5-Oxo-2,5-dihydrofuran-2-acetate
C19682  3,4-Didehydroadipyl-CoA
C19683  3,4-Didehydroadipyl-CoA semialdehyde
C19684  2,3-Epoxy-2,3-dihydrobenzoyl-CoA
C21298  2,6-Dihydroxybenzoate
Reference
  Authors
Carmona M, Zamarro MT, Blazquez B, Durante-Rodriguez G, Juarez JF, Valderrama JA, Barragan MJ, Garcia JL, Diaz E
  Title
Anaerobic catabolism of aromatic compounds: a genetic and genomic view.
  Journal
Microbiol Mol Biol Rev 73:71-133 (2009)
DOI:10.1128/MMBR.00021-08
Reference
  Authors
Hara H, Masai E, Miyauchi K, Katayama Y, Fukuda M.
  Title
Characterization of the 4-carboxy-4-hydroxy-2-oxoadipate aldolase gene and operon structure of the protocatechuate 4,5-cleavage pathway genes in Sphingomonas paucimobilis SYK-6.
  Journal
J Bacteriol 185:41-50 (2003)
DOI:10.1128/JB.185.1.41-50.2003
Reference
  Authors
Maruyama K, Shibayama T, Ichikawa A, Sakou Y, Yamada S, Sugisaki H.
  Title
Cloning and characterization of the genes encoding enzymes for the protocatechuate meta-degradation pathway of Pseudomonas ochraceae NGJ1.
  Journal
Biosci Biotechnol Biochem 68:1434-41 (2004)
DOI:10.1271/bbb.68.1434
Reference
  Authors
Mampel J, Ruff J, Junker F, Cook AM.
  Title
The oxygenase component of the 2-aminobenzenesulfonate dioxygenase system from Alcaligenes sp. strain O-1.
  Journal
Microbiology 145 ( Pt 11):3255-64 (1999)
DOI:10.1099/00221287-145-11-3255
Reference
PMID:8002948
  Authors
Junker F, Field JA, Bangerter F, Ramsteiner K, Kohler HP, Joannou CL, Mason JR, Leisinger T, Cook AM.
  Title
Oxygenation and spontaneous deamination of 2-aminobenzenesulphonic acid in Alcaligenes sp. strain O-1 with subsequent meta ring cleavage and spontaneous desulphonation to 2-hydroxymuconic acid.
  Journal
Biochem J 300 ( Pt 2):429-36 (1994)
DOI:10.1042/bj3000429
Reference
PMID:8990279
  Authors
Harwood CS, Gibson J.
  Title
Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes?
  Journal
J Bacteriol 179:301-9 (1997)
DOI:10.1128/JB.179.2.301-309.1997
Reference
  Authors
Peters F, Shinoda Y, McInerney MJ, Boll M.
  Title
Cyclohexa-1,5-diene-1-carbonyl-coenzyme A (CoA) hydratases of Geobacter metallireducens and Syntrophus aciditrophicus: Evidence for a common benzoyl-CoA degradation pathway in facultative and strict anaerobes.
  Journal
J Bacteriol 189:1055-60 (2007)
DOI:10.1128/JB.01467-06
Reference
  Authors
Cowles CE, Nichols NN, Harwood CS.
  Title
BenR, a XylS homologue, regulates three different pathways of aromatic acid degradation in Pseudomonas putida.
  Journal
J Bacteriol 182:6339-46 (2000)
DOI:10.1128/JB.182.22.6339-6346.2000
Reference
  Authors
Smith MA, Weaver VB, Young DM, Ornston LN.
  Title
Genes for chlorogenate and hydroxycinnamate catabolism (hca) are linked to functionally related genes in the dca-pca-qui-pob-hca chromosomal cluster of Acinetobacter sp. strain ADP1.
  Journal
Appl Environ Microbiol 69:524-32 (2003)
DOI:10.1128/AEM.69.1.524-532.2003
Reference
  Authors
Kuntze K, Shinoda Y, Moutakki H, McInerney MJ, Vogt C, Richnow HH, Boll M
  Title
6-Oxocyclohex-1-ene-1-carbonyl-coenzyme A hydrolases from obligately anaerobic bacteria: characterization and identification of its gene as a functional marker for aromatic compounds degrading anaerobes.
  Journal
Environ Microbiol 10:1547-56 (2008)
DOI:10.1111/j.1462-2920.2008.01570.x
Reference
  Authors
Pelletier DA, Harwood CS
  Title
2-Hydroxycyclohexanecarboxyl coenzyme A dehydrogenase, an enzyme characteristic of the anaerobic benzoate degradation pathway used by Rhodopseudomonas palustris.
  Journal
J Bacteriol 182:2753-60 (2000)
DOI:10.1128/JB.182.10.2753-2760.2000
Reference
  Authors
Elshahed MS, Bhupathiraju VK, Wofford NQ, Nanny MA, McInerney MJ
  Title
Metabolism of benzoate, cyclohex-1-ene carboxylate, and cyclohexane carboxylate by "Syntrophus aciditrophicus" strain SB in syntrophic association with H(2)-using microorganisms.
  Journal
Appl Environ Microbiol 67:1728-38 (2001)
DOI:10.1128/AEM.67.4.1728-1738.2001
Reference
  Authors
Nogales J, Canales A, Jimenez-Barbero J, Serra B, Pingarron JM, Garcia JL, Diaz E
  Title
Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida.
  Journal
Mol Microbiol 79:359-74 (2011)
DOI:10.1111/j.1365-2958.2010.07448.x
Related
pathway
reu00010  Glycolysis / Gluconeogenesis
reu00020  Citrate cycle (TCA cycle)
reu00350  Tyrosine metabolism
reu00360  Phenylalanine metabolism
reu00361  Chlorocyclohexane and chlorobenzene degradation
reu00627  Aminobenzoate degradation
reu00790  Folate biosynthesis
KO pathway
ko00362   
LinkDB

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