Rhinopithecus roxellana (golden snub-nosed monkey): 104667448
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Entry
104667448 CDS
T03989
Symbol
PDE8A
Name
(RefSeq) high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1
KO
K18437
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:
3.1.4.53
]
Organism
rro
Rhinopithecus roxellana (golden snub-nosed monkey)
Pathway
rro00230
Purine metabolism
rro01100
Metabolic pathways
rro04927
Cortisol synthesis and secretion
rro04934
Cushing syndrome
rro05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
rro00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
104667448 (PDE8A)
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
104667448 (PDE8A)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
104667448 (PDE8A)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
104667448 (PDE8A)
Enzymes [BR:
rro01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
104667448 (PDE8A)
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Gene cluster
GFIT
Motif
Pfam:
PDEase_I
PAS
PAS_9
PAS_4
PAS_3
PDE8
PAS_8
Sina_ZnF
DUF5894
Motif
Other DBs
NCBI-GeneID:
104667448
NCBI-ProteinID:
XP_010368162
UniProt:
A0A2K6PBJ7
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Position
5:106009719..106169522
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AA seq
827 aa
AA seq
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MGCAPSIHVSESLEVEDAPSPAASPLSSGGPRLPQGQKTAALSQTRGAGLLEPRDGSGRK
VAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLD
KHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFIAAGFTR
RYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRVIQYANP
AFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYARKKNGDNIQQ
NVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKIPECVQSDTHTDNQTGKHKDRRKGSLDV
KAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLEIL
RTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQTVSSNIVTPISLD
DVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWL
QIMEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPG
RTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTAGDDKCNIFKNMERNDYRTLRQGII
DMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEMINTMLRTPENRTLIKRMLI
KCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQDLPVVMPVFDRNTCSIPKSQISFI
DYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRSLRPPPE
NT seq
2484 nt
NT seq
+upstream
nt +downstream
nt
atgggctgtgcccccagcatccacgtttccgagagcctggaggtcgaggacgcacctagc
cccgcggcatcgccgctgtcttccggcgggccgcgcctcccgcagggccagaagacggcc
gccttgtcccagacccgcggcgccggcctcttggagcctcgcgacggcagcggcaggaag
gtagcagtagctgatgtgcaatttggccccatgagatttcatcaagatcaacttcaggta
cttttagtgtttaccaaagaagataaccaatgtaatggattctgcagggcatgtgaaaaa
gcagggtttaagtgtacagttaccaaggaggctcaggctgtccttgcctgtttcctggac
aaacatcatgacattatcatcatagaccacagaaatcctcgacaactggatgcagaggca
ctgtgcaggtctatcagatcatcaaaactctcagaaaacacagttattgttggtgtagta
cgcagggtggatagagaagagttgtccgtaatgcctttcattgctgctggatttacaagg
aggtatgtggaaaaccccaacatcatggcctgctacaatgaactgctccagctggagttt
ggagaggtgcgatcacaactgaaactcagggcttgtaactctgtattcactgcattagaa
aacagtgaagatgcaattgaaattacaagtgaagaccgtgttatacagtatgcaaatcct
gcatttgaaacaacaatgggctatcagtcaggtgaattaatagggaaggagttaggagaa
gtgcctataaatgaaaaaaaggctgacttgctcgatactataaattcatgcatcaggata
ggcaaggagtggcaaggaatttactatgccagaaagaaaaacggagataatatacaacaa
aatgtgaagataatacctgtcattggacagggaggaaaaattagacactatgtgtccatt
atcagagtatgcaatggcaacaataaggctgagaaaatacccgaatgtgttcagtctgac
actcatacagataatcagacaggcaaacataaagacagaagaaaaggctcactagacgtc
aaagctgttgcctcccgtgcaactgaagtttccagccagagacgacactcttccatggcc
cggatacattccatgacgattgaggcgcccatcaccaaggtaatcaatattatcaatgct
gcccaggaaagtagtcccatgcctgtgaccgaagccctagaccgtgtgctggaaattcta
agaaccactgagttatattcaccacagtttggtgctaaggatgatgatccccatgccaat
gaccttgttgggggcttaatgtctgatggtttgcgaagactatcagggaatgaatatgtt
ctttcaaccaaaaacactcaaacagtttcaagcaatatagtcactcccatctcccttgat
gatgtcccaccacggatagctcgggccatggaaaatgaagaatactgggactttgatatt
tttgaactggaggctgccacccacaataggcctttgatttatcttggtctcaaaatgttt
gctcgctttggaatctgtgaattcttacactgctctgagtcaacactaagatcgtggtta
caaattatggaagccaattatcattcttccaatccctaccacaattctacacattctgct
gatgtgcttcatgccactgcctattttctctccaaggagaggataaaggaaactttagat
ccaattgatgaggtcgctgcactcattgcagccaccattcatgatgtggatcaccctggg
agaaccaactccttcctgtgtaatgctggaagtgagctggccattttgtacaatgatact
gctgtgctggagagccaccatgcggccttggccttccagctgaccgctggagatgataaa
tgcaatatatttaaaaacatggagaggaatgactatcggacactgcgccaggggatcatc
gacatggtcttagccacggaaatgacaaagcactttgagcatgtcaacaaatttgtcaac
agcatcaacaaacccttggcaacgctagaagaaaatggggaaactgataaaaatcaggaa
atgataaacactatgcttaggactccagagaaccggactctaatcaaacgaatgctgatt
aaatgtgctgatgtgtccaatccctgccgacccctgcagtactgcatcgagtgggctgca
cgcatttcagaagaatatttttcgcagactgatgaagagaagcagcaggacttacctgtg
gtaatgccagtttttgacagaaatacctgcagcatccccaaatcccaaatctctttcatt
gattacttcatcacagacatgtttgatgcttgggatgcctttgtagacctgcctgattta
atgcagcatcttgacaacaactttaaatactggaaaggactggacgaaatgaagctacga
agcctccgaccacctcctgaatag
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