Streptomyces ambofaciens: SAM23877_4242
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Entry
SAM23877_4242 CDS
T04055
Name
(GenBank) Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
samb
Streptomyces ambofaciens
Pathway
samb00860
Porphyrin metabolism
samb01100
Metabolic pathways
samb01110
Biosynthesis of secondary metabolites
samb01120
Microbial metabolism in diverse environments
samb01240
Biosynthesis of cofactors
Module
samb_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
samb_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
samb00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
SAM23877_4242
Enzymes [BR:
samb01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
SAM23877_4242
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
SAM23877_4242
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
AKZ57287
UniProt:
A0A0K2AWT5
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Position
4506775..4508472
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AA seq
565 aa
AA seq
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MSPTTFTAGPEHGHVTFLGAGPGDPGLLTLRAVEALSHADVLVAEHEVLDVVRTHARQGV
TEVHTDTDPSDPGAGTPQLTVVDGSSTTVGVPAVRDAAHLVMEAARGGRRVVRAVTGDPG
LDTYAAEEMLACAAAGVPFEVVPGIANAVGVPAYAGVPLRDAEGADVRFVDARTASARCW
TEVGASDGTVVVSTTLDSVAAAAGELVSAGRKPDTPLTVTVAGTTTRQRTWTATLGTVAQ
TLKQAKVLPSPDGGRPVIAVVGERSAPARRDQLSWFESKPLFGWKVLVPRTKEQAASLSD
QLRSYGAVPSEVPTIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVKAVREKFEEYG
LDARAFAGIKVAAVGEQTAKALVAFGVKPDLVPSGEQSAAGLLEDWPPYDPVFDPIDRVF
LPRADIATETLVAGLIELGWEVDDVTAYRTVRASPPPATTREAIKGGGFDAVLFTSSSTV
RNLVGIAGKPHNVTVIACIGPATAKTAEEHGLRVDVMAPEPSVTKLAEALADFGLARRAA
ALEAGDPVTRPSERRPGARRRRSST
NT seq
1698 nt
NT seq
+upstream
nt +downstream
nt
gtgagccccaccacctttaccgccggtccggaacacgggcacgtcaccttcctcggtgcc
ggacccggagatccgggactgctgactctgcgcgccgtggaggcgctgtcgcacgcggat
gtcctcgtcgccgagcacgaggtgctcgacgtcgtgcgcacgcatgcgcggcagggcgtg
accgaggtgcacacggataccgatccgtcggatccgggtgcaggcacgccccagctgacg
gtagttgacggctcgtcaacgaccgtgggcgtccccgccgtgcgggatgccgcacatctt
gtcatggaggccgcgcggggcggcaggcgggtcgtgcgtgccgtgaccggggaccccggg
ctcgacacgtacgccgccgaggagatgctggcgtgcgccgcggccggggtgcccttcgag
gtcgtccccggtatcgcgaacgccgtcggtgtgcccgcgtacgccggtgtgccgctgcgg
gacgccgagggtgccgacgtgcggttcgtggacgcccgtacggcgtcggcccggtgctgg
accgaggtgggtgcctcggacgggacggtcgtcgtgtcgacgacgctcgactcggtggcc
gcggccgccggtgagctggtgtcggccggccgcaagccggacaccccgctgacggtgacg
gtcgccggtacgacgacccggcagcgcacctggacggcgacgctcggcacggtcgcgcag
acgctgaagcaggcgaaggtgctgccgtccccggacggtggccgtccggtgatagccgtg
gtcggcgagcgcagcgcccccgcccggcgcgaccagttgtcgtggttcgagtccaagccg
ctgttcggctggaaggtgctcgtgccgcgcacgaaggagcaggcggcgtcgctctccgac
cagctgcggtcgtacggggccgtacccagcgaggtgccgaccatcgcggtcgagccgccg
cgtacgccccagcagatggagcgggcggtcaagggcctggtgacgggccggtacgagtgg
atcgcgttcacgtcggtcaacgcggtgaaggcggtccgcgagaagttcgaggagtacggt
ctcgacgcccgtgcgttcgcgggcatcaaggtcgcggcggtgggcgagcagacggccaag
gccctcgtcgccttcggtgtgaagccggacctggtgccgagcggtgagcagtcggccgcc
ggactcctggaggactggccgccctacgacccggtcttcgacccgatcgaccgcgtcttc
ctgccccgcgccgacatcgccacggagacgctggtcgccgggctgatcgagctgggctgg
gaggtcgacgacgtcaccgcctaccggacggtgcgcgcgtcgccgccgccggccaccacc
cgcgaggcgatcaagggcggtggcttcgacgcggtgctgttcacctcgtcgtccacggtg
cggaacctggtcgggatcgcgggcaagccgcacaacgtcacggtgatcgcgtgcatcggc
ccggcgacggccaagacggccgaggagcacgggctgcgggtggacgtcatggcgcccgag
ccgtccgtcaccaagctggcggaggccctggccgacttcggcctggcgcgccgggcggcg
gccctggaggccggggacccggtgacgcggccgagcgagcggcggccgggggcgcgcagg
cgtcggtcctcgacgtga
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