Sorex araneus (European shrew): 101540495 Help Entry 101540495         CDS       T07854                                  Symbol INSR Name (RefSeq) insulin receptor   KO K04527   insulin receptor [EC:2.7.10.1] Organism sara  Sorex araneus (European shrew) Pathway sara04010   MAPK signaling pathway sara04014   Ras signaling pathway sara04015   Rap1 signaling pathway sara04022   cGMP-PKG signaling pathway sara04066   HIF-1 signaling pathway sara04068   FoxO signaling pathway sara04072   Phospholipase D signaling pathway sara04150   mTOR signaling pathway sara04151   PI3K-Akt signaling pathway sara04152   AMPK signaling pathway sara04211   Longevity regulating pathway sara04213   Longevity regulating pathway - multiple species sara04520   Adherens junction sara04910   Insulin signaling pathway sara04913   Ovarian steroidogenesis sara04923   Regulation of lipolysis in adipocytes sara04930   Type II diabetes mellitus sara04931   Insulin resistance sara04932   Non-alcoholic fatty liver disease sara04960   Aldosterone-regulated sodium reabsorption sara05010   Alzheimer disease sara05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:sara00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     101540495 (INSR)    04014 Ras signaling pathway     101540495 (INSR)    04015 Rap1 signaling pathway     101540495 (INSR)    04066 HIF-1 signaling pathway     101540495 (INSR)    04068 FoxO signaling pathway     101540495 (INSR)    04072 Phospholipase D signaling pathway     101540495 (INSR)    04022 cGMP-PKG signaling pathway     101540495 (INSR)    04151 PI3K-Akt signaling pathway     101540495 (INSR)    04152 AMPK signaling pathway     101540495 (INSR)    04150 mTOR signaling pathway     101540495 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     101540495 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     101540495 (INSR)    04923 Regulation of lipolysis in adipocytes     101540495 (INSR)    04913 Ovarian steroidogenesis     101540495 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     101540495 (INSR)   09149 Aging    04211 Longevity regulating pathway     101540495 (INSR)    04213 Longevity regulating pathway - multiple species     101540495 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     101540495 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     101540495 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     101540495 (INSR)    04932 Non-alcoholic fatty liver disease     101540495 (INSR)    04931 Insulin resistance     101540495 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:sara01001]     101540495 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:sara04090]     101540495 (INSR) Enzymes [BR:sara01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      101540495 (INSR) Protein kinases [BR:sara01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    101540495 (INSR) CD molecules [BR:sara04090]  Proteins   101540495 (INSR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like DUF4476 B2 Motif Other DBs NCBI-GeneID:  101540495 NCBI-ProteinID:  XP_004614932 LinkDB All DBs Position Unknown AA seq 1341 aa AA seqDB search MCEVLLKITTAPPGERYNRVICPSMDIRNNLTRLQDLANCSVIEGHLQILLMFKTRPEDF RDLSFPKLVMITDYLLLFRVYGLESLRDLFPNLTVIRGSRLFFNYALVVFEMVHLKELGL YSLMNITRGAVRIEKNNELCYLLTIDWSRILDSVEDNYIVKNKDDNEECGDICPGTAKGK TNCPATVINGQFVERCWTHNHCQKVCPTSCKSSGCTVEGLCCHSECLGNCLEPNDPSKCV ACRNFYLDGRCVDTCPRPYLHFQDWRCVDFNFCQALHNKCKNSRRPGCHQYVIHEDKCVP ECPSGYTMNSSNLLCTPCLGPCPKVCHLEGEKTIDSVTSAQELRGCTVINGSLVINIRGG NNLAAELEANLGLIEEISGYLKIRRSYALVSLAFFRKLRLIRGETLEMGNYSFYALDNQN LRQLWDWSAHKLTIAQGKLFFHYNPKLCLAEIHKMEEVSGTKGRQERNDVALKTNGDQAS CENVLLKFSFIKTSFDKIMLKWDPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSN SWTVVDIDPPPRSNDPKSQSQPGWLMRNLKPWTQYAIFVKTLVTFSDERRTYGAKSNIIY VQTNATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQVEDSELFELDYC LKGLKLPSRAWSPPSEAEGAQKHNRSESEESGSECCSCPKTDSQILKELEESSFRKTFED YLHNVVFVPRPSRKRRALGEVANVTAELVPTVLGTPTAPSTTSLPTSAEEQRPFEKVINK ESLVISGLRHFTGYRIEVQACNQEAPDERCSVAAYVSARTMPEAKADDIVGPVTHEIFEN NVVHLMWPEPKEPNGLIVLYEVSYRRYSDEELHLCVSRRHYALEGGCRLRGLSPGNYSVR IRATSLAGNGSWTEATYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRHP DGPLGPLYASSNPEYLSASDVFPCSMYVPDEWEVPREKIALLRELGQGSFGMVYEGNAKD IVKGEPETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVME LMAHGDLKSYLRSLRPDAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARN CMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGV VLWEITSLAEQPYQGLSNEQVLKFVMDGGFLEQPENCPERVTELMQLCWQFNPKMRPTFL EIVDLLKDDLHPSFPEVSFFHSEENKMPESEDLELELEDMESVPLDRALHPARDEENIPY THMNGGKKNGRILTLTRSNPS NT seq 4026 nt NT seq  +upstreamnt  +downstreamnt atgtgtgaggtccttctgaagatcaccacagcgccccctggtgagcgctacaaccgagtg atctgccccagcatggacatccggaacaacctgacgcggctgcaggacctggccaactgc tcggtcattgagggccacctccagatcctgctgatgttcaagacccgccccgaggacttc cgggacctcagtttccccaagctggtcatgatcacggactacctgctgctcttccgggtc tacgggctggagagcctccgggacctgttcccgaacctgacagtcatccggggctcccgg ctcttcttcaactacgcgctggtggtcttcgagatggtccacctcaaggagctgggcctg tacagcctcatgaacatcacgcgcggcgccgtgcgcatcgagaagaacaacgagctctgc tacctgctcaccatcgactggtcgcgcatcctggactccgtggaggacaactacatcgtg aagaacaaggacgacaacgaggagtgcggggacatctgccccggcacggccaagggcaag accaactgtccggccacggtcatcaatgggcagttcgtggagcgctgttggacgcacaac cactgccagaaagtctgcccgaccagctgtaagtcttcaggctgcacggtggaaggtctt tgctgccacagcgagtgtctgggtaactgcctggagcccaacgaccccagcaagtgtgtg gcctgccggaacttctacctggacggccgctgcgtggacacgtgtccccgcccctacctc cacttccaggactggcgctgcgtggacttcaacttctgccaggccctgcacaacaagtgc aagaactcacgtcggcctggctgccaccagtacgtcatccacgaggacaaatgcgtcccc gagtgcccctctgggtacacgatgaattccagcaacctgctgtgcaccccgtgtctgggc ccctgccccaaggtctgccacctggagggcgagaagaccatcgactcggtcacgtcagcc caggagctgcgaggttgcaccgtgatcaacgggagcttggtcatcaacattcgcgggggc aacaacctggcggcggagctggaggccaacctgggcctcatcgaggagatttccgggtac ctgaagatccgccgctcctacgcactcgtgtctctcgccttcttccggaagctccgcctg atccggggagaaacgctggagatggggaactactccttctatgccctggacaaccagaac ctacggcagctctgggactggagcgcgcacaagctcacgatcgcccagggcaagctcttc ttccactacaaccccaagctctgcctggccgagatccacaagatggaggaagtgtcggga accaagggccgccaggagcgcaacgacgtcgccctgaagaccaacggggaccaggcgtcc tgcgaaaacgtgctgctgaaattttctttcattaagacgtccttcgacaagatcatgctg aagtgggacccctactggccccccgacttcagagacctcttggggttcatgcttttctat aaggaagccccctatcagaacgtgacggagttcgacgggcaggatgcctgcggctccaac agctggaccgtggtggacattgacccgccgccgaggtccaacgaccccaaatcccagtcc cagcccgggtggctgatgaggaacctcaagccctggacccagtacgccatcttcgtcaag accctcgtcaccttttcggatgaacgtcgaacctacggggccaagagcaacatcatctac gtgcagaccaacgccacgaatccctccgtccccctggacccgatctccgtctccaattcc tcatcccagatcatcctcaagtggaagccgccgtcagaccccaacgggaacatcacccac tacctggtattctgggagcggcaggtggaggacagtgaactcttcgagctggattattgc ctcaaaggcttgaagctgccctcccgggcctggtccccgccatccgaggcggagggcgcc cagaagcacaaccggagtgagtccgaggagtccgggagtgagtgctgctcctgccccaag acggactcgcagatcctcaaggagctggaggaatcgtccttccggaagacattcgaggat tatctgcacaacgtcgtctttgtgccccggccgtcacgtaagcgccgggcattgggcgaa gtggccaatgtgacggcagagttggtgcccacggtgctgggcacccccaccgccccgtcc accaccagcctgcccacgagcgcggaggagcagaggccgttcgagaaggtgatcaataag gagtcgctggtcatctcgggcctacgccacttcacggggtaccgcatcgaggtgcaggcc tgcaaccaggaggcgcccgacgagcgctgcagcgtggccgcctacgtgagcgcccgcacc atgcccgaagccaaggcagatgacatcgtgggccccgtgacccacgagatctttgagaac aatgtcgtgcacctgatgtggccggagcccaaggagcccaacgggctgatcgtgctgtac gaagtgagttaccggcgctacagcgatgaggagctgcacctctgcgtgtcccgcagacat tatgcgctggaggggggctgccgcctgcgaggcctttccccggggaattacagtgtgagg atccgggccacttccctggcgggcaacggctcctggacggaagccacttatttctatgtg actgactatttggatgtcccgtccaacattgcgaaaattatcattggcccgctcatcttt gtctttctcttcagtgttgtgatcggaagtatttatctcttcctgaggaagaggcacccc gatggcccgctggggccgctgtacgcatcgtcaaaccctgagtacctcagtgccagcgat gtcttcccctgttccatgtacgtgcccgacgagtgggaggtgccacgggagaagatcgcc ctgctgcgcgagctgggccagggctccttcggcatggtctacgagggcaacgccaaggac atcgtcaagggtgagccggagacccgcgtggccgtgaagaccgtcaacgagtcggccagc ctgcgggagcggatcgagtttctcaacgaggcctcggtcatgaagggcttcacctgccac cacgtggtccgcctcctgggcgtggtgtccaaagggcagcccacgctggtggtcatggag ctgatggcgcacggggacctcaagagttacctgcgctccctgcgccccgacgccgagaat aatccgggtcgccccccgcctacactgcaagaaatgattcagatggcggcggagatcgcg gatggcatggcatacctcaacgccaagaagttcgtgcaccgcgacctcgcggcccgtaac tgcatggtcgcccacgatttcactgtcaagatcggagacttcgggatgaccagggacatc tacgagacagattactaccgcaaggggggcaagggcctgctccccgtgcgctggatggcc cccgagtccctcaaggacggcgtcttcaccacgtcttcagacatgtggtccttcggcgtg gtcctctgggaaatcaccagcctggctgagcagccataccagggcctgtcgaacgagcag gtcctcaagttcgtcatggacggagggtttctggagcagccggagaattgtccggagaga gtcacggagctgatgcagctttgctggcagttcaaccccaagatgcggcccacattcctg gagatcgtggacctcctcaaggacgacctgcaccccagcttccccgaggtgtccttcttc cacagcgaggagaacaagatgcccgagagcgaggacctggagctggagctggaggacatg gagagcgtccccctggaccgcgccctgcacccggcccgggacgaggagaacatcccctac acccacatgaacgggggcaagaaaaacggacggattctgactctcactcggtccaacccg tcctaa

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