Streptomyces calvus: CD934_17305
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Entry
CD934_17305 CDS
T06819
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
sast
Streptomyces calvus
Pathway
sast00860
Porphyrin metabolism
sast01100
Metabolic pathways
sast01110
Biosynthesis of secondary metabolites
sast01120
Microbial metabolism in diverse environments
sast01240
Biosynthesis of cofactors
Module
sast_M00121
Heme biosynthesis, plants and bacteria, glutamate => heme
sast_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
sast_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
sast00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
CD934_17305
Enzymes [BR:
sast01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
CD934_17305
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
CD934_17305
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
QDI70258
UniProt:
A0A514JUD6
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Position
4079586..4081283
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AA seq
565 aa
AA seq
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MSPTTLPAPPEHGHVTFLGAGPGDPGLLTLRAVEALANADVLVAEHEVLDVVRTHARQGV
AEVHTDADPSAPGTGTPQLTVVDGASTTAPVPAVRDAAHLVMEAARGGRRVVRAVSGDPG
LDAYAAEEMLACASAGVPFEVVPGIATAVGVPAYAGVPLRDAQGADVRFVDARTASDRCW
TEVGASDGTVVVSTTLDSVAAAAGELVSAGRKPDTPLTVTVAGTTTRQRTWQATLGTIAQ
TLKQAKVLPSPDGGRPVIAVVGERSAAAQRDRLAWFESKPLFGWKVLVPRTKEQAASLSD
QLRSYGAVPHEVPTIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVKAVREKFEEYG
LDARAFAGIKVAAVGEQTANALIAFGVKPDLVPSGEQSAAGLLEDWPPYDPVFDPIDRVF
LPRADIATETLVAGLIELGWEVDDVTAYRTVRASPPPAETREAIKGGGFDAVLFTSSSTV
RNLVGIAGKPHNVTVIACIGPATAKTAEEHGLRVDVMAPEPSVHKLAEALADFGMRRRMA
ALEAGDPVTRPSERRPGARRRRSTT
NT seq
1698 nt
NT seq
+upstream
nt +downstream
nt
ttgagccccaccacccttcccgcccctccggaacacgggcacgtcaccttcctcggtgcc
ggacccggggatccgggactgctgactctgcgcgccgtggaggcgctggcgaacgcggac
gtcctcgtcgccgagcacgaggtgctcgacgtggtgcgaacgcacgcgcggcagggcgtc
gccgaggtgcacacggatgccgatccgtcggctccgggcacgggcacgccccagctgacg
gtcgttgacggcgcgtcaacaaccgcccctgtccccgcggtgagggatgccgcacatctt
gtcatggaggccgcgcggggcggcaggcgggtcgtgcgtgcggtgtccggtgaccccggg
ctcgacgcgtacgccgccgaggagatgctggcgtgcgcctcggccggtgtgccgttcgag
gtcgttccgggtatcgcgaccgctgtcggtgtgcccgcgtacgccggtgtgccgctgcgg
gacgcgcagggcgcggacgtgcggttcgtcgacgcccgtaccgcatccgaccggtgctgg
acggaggtcggtgcgtcggacggcacggtggtcgtctccaccacgctggactccgtggcc
gcggcggcgggcgaactggtgtccgccggtcgcaagcccgacacccccctgacggtgacc
gtcgccggtacgacgacgcggcagcgcacctggcaggcgacgctcggcacgatcgcgcag
acgctgaagcaggcgaaggtgctgccgtccccggacggcggccggccggtgatagccgtg
gtcggtgagcgcagtgccgccgcgcagcgcgaccggctggcgtggttcgagtccaagccg
ctgttcggctggaaggtcctcgttccgcggacgaaggagcaggcggcgtcgctctccgac
cagttgcggtcctacggtgccgtgccgcacgaggtgccgacgatcgccgtggagccgccg
cgcacgccgcagcagatggagcgggcggtcaagggcctggtgacgggccgctacgagtgg
atcgcgttcacctcggtcaacgcggtcaaggcggtccgtgagaagttcgaggagtacggc
ctcgacgcgcgtgccttcgccggtatcaaggtcgcggcggtgggcgagcagaccgcgaac
gcgctgatcgccttcggtgtgaagccggacctggtgccgagcggtgagcagtcggccgcc
ggtctgctggaggactggccgccgtacgacccggtcttcgacccgatcgaccgcgtcttc
ctgcctcgcgccgacatcgccacggagacgctggtcgccgggctgatcgagctgggctgg
gaggtcgacgacgtgaccgcctaccggacggtgcgtgcgtcgccgccgccggcggagacc
cgtgaggcgatcaagggcggtggcttcgacgcggtgctgttcacgtcgtcgtccacggtg
cggaacctggtcggcatcgccggcaagccgcacaacgtcacggtgatcgcctgcatcggc
ccggcgacggcgaagacggccgaggagcacggcctgcgcgtcgacgtcatggctcccgag
ccgtcggtgcacaagctggcggaggcgctggccgacttcggtatgcgccgacggatggcg
gcgctggaggccggcgacccggtgacgcggccgagcgagcggcggccgggcgcgcggagg
cgtcggtcgacgacctga
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