Streptomyces clavuligerus: BB341_16690
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Entry
BB341_16690 CDS
T04717
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
sclf
Streptomyces clavuligerus
Pathway
sclf00860
Porphyrin metabolism
sclf01100
Metabolic pathways
sclf01110
Biosynthesis of secondary metabolites
sclf01120
Microbial metabolism in diverse environments
sclf01240
Biosynthesis of cofactors
Module
sclf_M00121
Heme biosynthesis, plants and bacteria, glutamate => heme
sclf_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
sclf_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
sclf00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
BB341_16690
Enzymes [BR:
sclf01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
BB341_16690
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
BB341_16690
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Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
ANW19740
UniProt:
B5GQ14
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Position
4115595..4117253
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AA seq
552 aa
AA seq
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MSPTTNPSSAFSAHGHVTFLGAGPGDPGLLTLRAVEALAGADVLIAEPEVLEVVRGHARA
SVSAPELTTVDDASTAAGIPVLRDAVNLVMEAARGGKRVVRAVTGDPGLDADAGQEMLAC
AAEGIPFEVVPGVAAAVGVPAYAGVPLRDAQGTDVRFVDARTASERCWTEVGASDGTAVV
STTLDAVAAAAGELVAAGRKPDTPLTVTVAGTTTRQRTWTATLGSIAQTLKQAKVLPSPD
GHRPVIAVVGERSSAAQRDQLAWFESKPLFGWRVLVPRTKEQAASLSDQLRSYGAVPHEV
PTIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVKAVREKFEEYGLDARAFAGIKVA
AVGEQTARALVDFGVKPDLVPSGEQSAAGLLEDWPPYDPVFDPIDRVFLPRADIATETLV
AGLIELGWEVDDVTAYRTVRASPPPAETREAIKGGGFDAVLFTSSSTVRNLVGIAGKPHN
VTVIACIGPATAKTAEEHGLRVDVLSPEPSVHRLAEALAEFGAARRLTAVEAGEHVLRPS
ERRPGGRRRRTT
NT seq
1659 nt
NT seq
+upstream
nt +downstream
nt
ttgagccccaccaccaacccgtcctcggcgttctcggcacacgggcacgtcactttcctc
ggcgccggtcccggcgatcccggactgctgaccctgcgcgctgtcgaggcgctcgcgggt
gccgatgtactgatcgccgagccagaggtgctcgaagtggtacgcggccatgcgcgggcg
agcgtcagcgcgccggagctgacgactgttgacgatgcgtcaacagccgccggaatccct
gtactcagggatgcggtcaatcttgtcatggaggcggcgcggggcggcaagcgggtcgtc
cgagcggtgaccggcgatcccggtctcgacgccgacgcgggccaggagatgctggcgtgc
gcggccgagggcatcccgttcgaggtcgtccccggtgtcgccgccgcggtcggcgtgccc
gcgtacgccggtgtgccgctgcgggacgcacaggggacggacgtccgtttcgtggacgcc
cgtaccgcgagcgagcgctgctggaccgaggtgggcgcgagcgacggcacggccgtcgtc
tccaccacgctggacgcggtcgccgcggcggcgggtgaactggtggcggcgggccgcaag
cccgacaccccgctgaccgtcacggtcgccgggacgaccacccggcagcggacctggacc
gcgacgctgggctccatcgcgcagacgctcaagcaggcgaaggtgctgccgtccccggac
gggcaccggccggtgatagccgtggtcggtgagcgcagctccgccgcgcagcgggaccag
ctcgcctggttcgagtccaagccgctcttcggctggcgggtgctggtgccgcggaccaag
gagcaggcggcgtcgctctccgaccagctccggtcctatggcgcggtcccgcacgaggtc
ccgaccatcgccgtcgagccgccgcgtactccgcagcagatggaacgggcggtcaagggc
ctggtcaccgggcggtacgagtggatcgccttcacgtccgtcaacgcggtcaaggcggtg
cgggagaagttcgaggagtacgggctcgacgcgcgcgccttcgcggggatcaaggtcgcg
gcggtgggcgagcagaccgcgcgggccttggtcgacttcggtgtgaagccggacctggtg
ccgagcggtgagcagtccgcggcgggtctgctggaggactggccgccgtacgacccggtc
ttcgacccgatcgaccgggtgttcctgccgcgtgcggacatcgccacggagacgctggtc
gcgggcctgatcgagctgggctgggaggtcgacgacgtcaccgcgtaccggacggtgcgg
gcgtcgccgccgccggccgagacccgtgaggcgatcaagggtggcggcttcgacgcggtc
ctgttcacctcgtcctcgacggtgcggaatctggtcgggatcgcgggcaagccgcacaac
gtcacggtgatcgcgtgcatcggtccggcgaccgcgaagacggcggaggagcacgggttg
cgggtggacgtcctgtcgcccgagccgtccgtgcaccggctggccgaggcgctggccgaa
ttcggcgcggcgcgccggctcaccgcggtggaggccggcgaacacgtcctccgcccctcc
gaacgccgccccggcggccgtcgccgccgcaccacctga
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