Saccharopolyspora erythraea: SACE_6944
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Entry
SACE_6944 CDS
T00492
Symbol
hemD
Name
(GenBank) uroporphyrinogen III synthase/methyltransferase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
sen
Saccharopolyspora erythraea
Pathway
sen00860
Porphyrin metabolism
sen01100
Metabolic pathways
sen01110
Biosynthesis of secondary metabolites
sen01120
Microbial metabolism in diverse environments
sen01240
Biosynthesis of cofactors
Module
sen_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
sen_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
sen00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
SACE_6944 (hemD)
Enzymes [BR:
sen01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
SACE_6944 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
SACE_6944 (hemD)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
B12-binding
Motif
Other DBs
NCBI-ProteinID:
CAM06107
Kitasato:
SACE_6944
Cambridge:
SACE_6944
UniProt:
A4FPY2
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Position
complement(7760152..7761684)
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AA seq
510 aa
AA seq
DB search
MTRARKTPGRIAFVGSGPGDAGLLTVRARHVITSASLVVTDPDVPADIVGLAAEGAEVRP
AVGDPADVALDLANEAKTGRPVVRLVAGDPLTADAVVREVQAVAKTDVAFDIVPGVPAGS
AVPAYAGVALGAVHAEVDVRGDVDWASLAKVPGALVLHTAGTHLAEAASALVEHGRAAQT
PVAVTASGTTVQQRTIDTTLASLAADAGELQGQLVVTIGDVVSERNSLSWWESRALYGWK
VLVPRTKEQAGSMSERLWSHGAVSHEVPTISVEPPRSPAQMERAVKGLVDGRYQWVVFTS
TNAVRAVWEKFREFGLDARAFSGVKIACVGEATAEKVRSFGINPELVPSGEQSSEGLLQD
FPPHDDILDPVDRVLLPRADIATETLAAGLRERGWEIDDVTAYRTVRAAPPPAETREMIK
TGGFDAVCFTSASTVRNLVGIAGKPHARTLVACIGPSTAETAKEFGLRVDVQPEVPQIPV
LVDALAEHAARLRAEGALPPPKKAKRARRS
NT seq
1533 nt
NT seq
+upstream
nt +downstream
nt
atgacccgagcacgtaagacccccggacggattgctttcgtgggctcaggccccggtgat
gctggactgctcaccgtccgggccaggcacgtgatcaccagcgcatcgctggtggtcacc
gatccggacgtacccgccgacatcgtcgggctggccgccgagggcgccgaggtgcgcccc
gcggtgggcgacccggccgacgtggcgctggacctggccaacgaggccaagacgggccgc
cccgtggtccggctggtcgcgggcgacccgctgaccgccgacgcggtggtgcgcgaggtg
caggcggtcgccaagaccgacgtcgccttcgacatcgttcccggcgttcccgccggctcc
gcggtgcccgcctacgcgggtgtcgcgctgggcgcggtgcacgccgaggtcgatgtccgc
ggcgacgtcgactgggcctcgctggccaaggtgccgggtgcgctggtgctgcacaccgcg
ggcacccacctggccgaggcggcctccgcgctggtcgagcacggcagggccgcgcagacc
ccggtcgcggtgaccgcgtcgggcaccacggtccagcagcgcaccatcgacaccacgctg
gcctcgctggccgccgacgccggtgagctgcaggggcagctcgtggtgaccatcggcgac
gtggtgtccgagcgcaacagcctgtcgtggtgggagtcccgcgccctgtacggctggaag
gtcctggtgccgcgcaccaaggagcaggccggttcgatgagcgagcggctctggtcgcac
ggcgccgtctcgcacgaggtcccgacgatctcggtggagccgccgcgcagccccgcgcag
atggagcgcgcggtcaagggcctggtcgacggccgttaccagtgggtggtgttcacctcg
accaacgccgtgcgcgcggtgtgggagaagttccgggagttcgggctggacgcccgcgcc
ttctccggcgtcaagatcgcctgcgtcggcgaggccaccgcggagaaggtccgctccttc
ggcatcaaccccgagctggtcccctccggggagcagtccagcgagggtctgctgcaggac
ttcccgccgcacgacgacatcctggacccggtggaccgggtgctgctgccgcgcgcggac
atcgccaccgagacgctggcggccggtctgcgcgagcgcggctgggagatcgacgacgtg
acggcctaccgcacggtgcgggcggcgccgccgccggccgagacccgggagatgatcaag
accggcgggttcgacgcggtctgcttcacctcggcctcgaccgtgcgcaacctggtcggc
atcgcgggcaagccgcacgcgcggaccctggtggcctgcatcggcccgagcacggcggag
acggccaaggagttcggcctgcgcgtcgacgtccagccggaggtcccgcagatcccggtc
ctggtcgacgccctggccgagcacgccgcccgcctccgcgccgaaggcgccctcccgccc
ccgaagaaggccaagagggcccggaggtcttga
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