Streptomyces fradiae: CP974_17200
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Entry
CP974_17200 CDS
T07648
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
sfb
Streptomyces fradiae
Pathway
sfb00860
Porphyrin metabolism
sfb01100
Metabolic pathways
sfb01110
Biosynthesis of secondary metabolites
sfb01120
Microbial metabolism in diverse environments
sfb01240
Biosynthesis of cofactors
Module
sfb_M00121
Heme biosynthesis, plants and bacteria, glutamate => heme
sfb_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
sfb_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
sfb00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
CP974_17200
Enzymes [BR:
sfb01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
CP974_17200
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
CP974_17200
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Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
QEV13439
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Position
3839355..3841022
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AA seq
555 aa
AA seq
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MSPTTASKASSAFSACGHVTFLGAGPGDPGLLTLRAVEALAGADVLIAEPEVLDVVRGHA
RAGVSTPELTVVDDASMAAGVPVLRDAANLVMEAARGGKRVVRALSGDPGLDGDAGAEML
ACASAGIPFEVVPGVAAAVGVPAYAGVPLRDAQGADVRFVDARTASDRCWTEVGASDGTV
VVSTTLDSVAAAAGELVAAGRKPDTPLTVTIAGTTTRQRTWTATLGSIAQTLKQAKVLPS
PEGHRPVIAVVGERSAAAQRDQLAWFESKPLFGWKVLVPRTKEQAASLSDQLRSYGAVPS
EVPTIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVKAVREKFEEYGLDARAFAGIK
VAAVGEQTAKALVDFGVKPDLVPSGEQSAAGLLEDWPPYDPVFDPIDRVFLPRADIATET
LVAGLIELGWEVDDVTAYRTVRASPPPAETREAIKGGGFDAVLFTSSSTVRNLVGIAGKP
HNVTVIACIGPATAKTAEEHGLRVDVLSPEPSVTKLAEALAEFGAKRRAAALEAGDPVTR
PSERRPGARRRRTTT
NT seq
1668 nt
NT seq
+upstream
nt +downstream
nt
ttgagccccaccactgcatccaaggcttcctcggcgttctccgcgtgcgggcacgtcacc
ttcctcggcgccggacccggtgatccggggctgctgactctgcgcgccgtggaggcgctg
gcgggcgctgacgtactgatcgccgagcccgaagtgctcgacgtcgtacgcggccatgcc
cgagcgggggtgagcacgcccgagctgacggttgttgacgatgcgtcaatggccgccggg
gtcccggtgttgagggacgcagccaatcttgtcatggaggccgcgcggggcggcaagcgg
gtggtgcgtgcgctcagcggcgacccgggcctcgacggcgacgcgggcgccgagatgctc
gcctgcgcgtccgccggcatccccttcgaggtggtgcccggtgtcgccgcggcggtcggc
gtgcccgcgtacgccggtgtcccgctgcgggacgcgcagggcgcggacgtgcggttcgtg
gacgcccgtacggccagcgaccggtgctggacggaggtcggcgcgtccgacggcacggtc
gtcgtgtccacgacgctggactcggtcgccgctgccgccggtgagctggtcgcggccggg
cggaagccggacaccccgctgaccgtcaccatcgccggtacgacgacccggcagcggacg
tggaccgccacgctcggctcgatcgcccagacgctgaagcaggcgaaggtgctgccctcc
ccggagggccaccggcccgtcatagccgtggtcggtgagcgcagcgccgccgcccagcgc
gaccagctcgcgtggttcgagtccaagccgctgttcggctggaaggtcctcgtcccgcgc
accaaggagcaggcggcgtcgctctccgaccagctcaggtcgtacggggcggtgcccagc
gaggtcccgaccatcgcggtcgagccgccgcgcaccccgcagcagatggagcgggcggtc
aagggcctggtcaccggccgctacgagtggatcgccttcacctcggtcaacgccgtgaag
gccgtccgcgagaagttcgaggagtacgggctcgacgcccgcgccttcgccgggatcaag
gtcgcggcggtcggcgagcagaccgcgaaggccctggtcgacttcggcgtcaagccggac
ctggtgcccagcggcgagcagtccgcggccgggctcctggaggactggccgccgtacgac
ccggtcttcgacccgatcgaccgggtgttcctgccgcgcgccgacatcgccaccgagacg
ctggtggccgggctcatcgagctgggctgggaggtggacgacgtcacggcctaccggacc
gtgcgcgcgtcgccgcccccggcggagacccgcgaggcgatcaagggcggcggcttcgac
gcggtgctgttcacgtcgtcgtcgaccgtgcggaacctggtcggcatcgcgggcaagccg
cacaacgtcaccgtgatcgcctgcatcggcccggccaccgccaagacggcggaggagcac
ggcctgcgcgtggacgtgctgtcgccggagccgtcggtgacgaagctggcggaggccctg
gcggagttcggcgcgaagcgccgcgccgccgcgctggaggcgggcgacccggtcacccgt
ccctccgagcggcgccccggcgcccgccgccgccgcacgacgacctga
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