Streptomyces aurantiacus: GCM10017557_47240
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Entry
GCM10017557_47240 CDS
T07085
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
sgm
Streptomyces aurantiacus
Pathway
sgm00860
Porphyrin metabolism
sgm01100
Metabolic pathways
sgm01110
Biosynthesis of secondary metabolites
sgm01120
Microbial metabolism in diverse environments
sgm01240
Biosynthesis of cofactors
Module
sgm_M00121
Heme biosynthesis, plants and bacteria, glutamate => heme
sgm_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
sgm_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
sgm00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
GCM10017557_47240
Enzymes [BR:
sgm01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
GCM10017557_47240
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
GCM10017557_47240
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Gene cluster
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Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
BCL29865
UniProt:
A0A7G1P9T4
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Position
5438580..5440268
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AA seq
562 aa
AA seq
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MSPTTLPVGLEHGHVTFLGAGPGDPGLLTLRAVEALGNADVLVAEPEVLDVVRTHARRNV
TVLDTEPGPSPDTPQLKVVDGVSATSGVPASKDAANIVMEAARGGRRVVRAVSGDPGLDA
YAAGEMLACAAAGVPFEVVPGVAAAVGVPAYAGVPLRDAEGADVRFVDARTASGRCWTEV
GASDGTVVVSATLDSVGAAAGELVAAGRKPDTPMAVTVAGTTTRQRTWSATLGTIAQTLK
QAKVLPSPEGGRPVIAVVGERSSAAQRDQLSWFESKPLFGWKVLVPRTKEQAASLSDQLR
SYGAVPHEVPTIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVKAVREKFEEYGLDA
RAFAGIKVAAVGEQTAKALVAFGVKPDLVPSGEQSAAGLLEDWPPYDPVFDPIDRVFLPR
ADIATETLVAGLIELGWEVDDVTAYRTVRASPPPAETREAIKGGGFDAVLFTSSSTVRNL
VGIAGKPHNVTVIACIGPATAKTAEEHGLRVDVMSPEPSVHRLAEALAEFGLRRRTSALE
AGDPVTRPSERRPGSRRRRSTT
NT seq
1689 nt
NT seq
+upstream
nt +downstream
nt
ttgagccccaccacccttcccgtcggcctcgaacacgggcacgtcaccttcctcggtgcc
ggacccggtgatcctggactgctgactctgcgcgccgtggaggcgctggggaacgcggat
gtcctggtcgccgaacccgaagtgctcgacgtcgtccgcacgcacgccagacgaaacgtc
accgtgctcgacaccgaaccgggcccgagcccggacacgcctcagctaaaggtagttgac
ggagtgtcagccacctctggcgtccccgcgtcgaaggacgcggccaatattgtcatggag
gccgcgaggggcggcaggcgggtcgtccgtgcggtctcgggtgaccccgggctcgacgcg
tacgccgccggggagatgctcgcctgcgccgccgcaggggtgccgttcgaggtcgttccc
ggtgtcgccgccgctgtgggtgtgcccgcgtacgcgggtgtgccgttgcgggacgccgag
ggcgcggacgtgcggttcgtcgacgcccgcacggcgtccgggcggtgctggaccgaggtc
ggcgcgtccgacgggaccgtggtcgtctcggcgaccctcgattccgtgggggcggccgcg
ggggaactcgtcgccgcgggccgcaagcccgacaccccgatggccgtgaccgtcgcgggt
acgacgacccgtcagcggacctggtccgcgacgctcggcaccatcgcgcagacgctgaag
caggccaaggtgctgccctcgcccgagggtggccggccggtgatagccgtggtcggtgag
cgttcctccgccgcccagcgcgaccagctgtcgtggttcgagtccaagccgctgttcggc
tggaaggtactcgtgccgcgtacgaaggagcaggcggcgtcgctctccgaccaactgcgg
tcgtacggggccgtgccgcacgaggtgccgacgatcgccgtcgagccgccgcgcacgccc
cagcagatggagcgggccgtcaagggcctggtgacgggccgttacgagtggatcgccttc
acctccgtgaacgccgtcaaggccgtacgggagaagttcgaggagtacgggctcgacgcg
cgggccttcgccgggatcaaggtcgccgcggtgggcgagcagaccgcgaaggcgctggtc
gccttcggtgtgaagccggacctggtgcccagcggggagcagtcggccgcgggtctgctg
gaggactggccgccgtacgacccggtcttcgacccgatcgaccgggtgttcctgccgcgt
gccgacatcgcgacggagacgctggtcgccgggttgatcgagctgggctgggaggtcgac
gacgtcaccgcctaccggaccgtacgggcctcgcccccgcctgcggagacccgggaggcg
atcaagggcggcggtttcgacgccgtgctcttcacgtcgtcctccaccgtgcggaacctg
gtgggcatcgccgggaagccgcacaacgtgaccgtgatcgcgtgtatcggtcccgccacg
gcgaagacggccgaggagcacgggctgcgggtcgacgtcatgtcgccggagccgtcggtg
caccggctggccgaggcgctggcggagttcgggctgcggcgccggacctcggcccttgag
gccggggaccccgtcacccggcccagcgagcggcggccggggtcccggcggcggcggtcg
acgacctga
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