Streptomyces inhibens: KI385_21295
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Entry
KI385_21295 CDS
T08140
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
sine
Streptomyces inhibens
Pathway
sine00860
Porphyrin metabolism
sine01100
Metabolic pathways
sine01110
Biosynthesis of secondary metabolites
sine01120
Microbial metabolism in diverse environments
sine01240
Biosynthesis of cofactors
Module
sine_M00121
Heme biosynthesis, plants and bacteria, glutamate => heme
sine_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
sine_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
sine00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
KI385_21295
Enzymes [BR:
sine01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
KI385_21295
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
KI385_21295
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GFIT
Motif
Pfam:
HEM4
TP_methylase
B12-binding
Motif
Other DBs
NCBI-ProteinID:
UKY51104
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Position
complement(4645920..4647578)
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AA seq
552 aa
AA seq
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MNPTAPNHSASGQVTFLGAGPGDPGLLTLRAVEALASADVLIADPHVLDVVRVHARAQVD
TPLQASADEASIPVTAPGVSALRDTANLVMAAARAGKRVVRAVTGDPGLDGNVAEEMLAC
ATEGIVFEVVPGIAAAVGVPAYAGVPLRDAQGTDVRFVDARSANDRCWSELGASDATAVV
STTLDSVAAAAGELVSAGRKPDTPMTITVAGTTTRQRTWTATLGSVAQVLKAAKVLPSPD
GGQPVIAVVGERSAAAQRDRLSWFESKPLFGWRVLVPRTKEQAASLSDQLVSYGAVSHEV
PTIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVKAVREKFEEYGLDARAFAGIKVA
AVGEQTAKALVAFGVKPDLVPSGEQSAAGLLEDWPPYDPVFDPIDRVFLPRADIATETLV
AGLIELGWEVDDVTAYRTVRASPPPAETREAIKGGGFDAVLFTSSSTVRNLVGIAGKPHN
VTVIACIGPATAKTAEEHGLRVDVMSPEPSVHKLAEALADFGAARRDAALEAGDPVTRPS
ERRPGSRRRARS
NT seq
1659 nt
NT seq
+upstream
nt +downstream
nt
ttgaaccccaccgccccaaaccactccgcctccggtcaggtcaccttcctgggtgccggg
ccgggagacccgggtctgctgacgctgcgtgccgtggaggcgctggcctccgcggacgta
ctgatcgccgacccgcacgtgctggacgtcgtgcgtgtgcatgcacgcgcacaggtggac
acgccactgcaggcgtcagctgacgaggcgtcaattcccgtcactgcccctggcgtttcg
gcccttcgggacaccgccaatcttgtcatggcggccgcccgcgcgggcaagcgggtcgta
cgtgccgtcaccggtgaccccggcctggacgggaacgtcgccgaggagatgctggcctgc
gccaccgaaggcatcgtcttcgaggtcgtgcccggcatcgccgcggccgtcggcgtaccc
gcgtacgccggtgtgccgctgcgcgacgcccagggcacggacgtgcgcttcgtcgacgcc
cgcagcgccaacgaccgctgctggtccgagctgggtgccagcgacgccaccgccgtcgtc
tccaccaccctcgactcggtggccgcggccgccggcgagctggtgtccgcgggccgcaag
cccgacaccccgatgaccatcaccgtcgccggcaccaccacccgccagcggacctggacc
gcgaccctcgggtcggtcgcccaggtgctcaaggccgccaaggtgctgccctcgcccgat
ggcggccagccggtcatagccgtggtcggtgagcgcagtgccgccgcgcagcgcgaccgc
ctttcgtggttcgagtccaagccgctcttcggctggcgggtgctcgtgccgcggacgaag
gagcaggccgcgtcgctctccgaccagctcgtctcgtacggtgcggtgtcgcacgaggtc
ccgaccatcgccgttgaaccgccacgcacccctcagcagatggagcgcgcggtcaagggc
ctggtcaccggccgctacgagtggatcgccttcacctcggtcaacgccgtcaaggccgtc
cgggagaagttcgaggagtacggcctggacgcccgcgccttcgccgggatcaaggtcgcg
gcggtcggcgaacagaccgccaaggcgctggtcgccttcggtgtgaagcccgacctggtg
ccctccggcgagcagtcggccgccgggctgctggaggactggccgccctacgacccggtc
ttcgacccgatcgaccgggtgttcctgccgcgcgccgacatcgccaccgagaccctggtg
gccgggctgatcgagctgggctgggaggtcgacgacgtcaccgcctaccggaccgtgcgc
gcctcgccgccgccggccgagacccgcgaggcgatcaagggcggcggcttcgacgcggtc
ctgttcacctcgtcctcgaccgtgcgcaacctcgtcggcatcgccggcaagccgcacaac
gtgaccgtgatcgcctgtatcggcccggccactgccaagaccgccgaggagcacgggctg
cgcgtggacgtcatgtcgcccgagccttcggtacacaagctggccgaagcgctcgccgac
ttcggggcggcgcggcgcgatgccgcgctggaggccggtgatccggtcacccgtcccagc
gagcgccggcccggatcgcgtaggagggctcgcagttga
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