Streptomyces kanamyceticus: CP970_18720
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Entry
CP970_18720 CDS
T06849
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
ska
Streptomyces kanamyceticus
Pathway
ska00860
Porphyrin metabolism
ska01100
Metabolic pathways
ska01110
Biosynthesis of secondary metabolites
ska01120
Microbial metabolism in diverse environments
ska01240
Biosynthesis of cofactors
Module
ska_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
ska_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
ska00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
CP970_18720
Enzymes [BR:
ska01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
CP970_18720
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
CP970_18720
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Gene cluster
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Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
QEU92670
UniProt:
A0A5J6GA53
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Position
complement(4457562..4459220)
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AA seq
552 aa
AA seq
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MSPTSNFPGTPAHGHVTFLGAGPGDPGLLTLRAVEALARADVLIAEPDVLDVVRVHARGG
VDTPRAAAVDDASAAVDAPSARAAANLVMEAARGGRRVVRAVSGDPGLDTYAAGEMLACA
AEGISFEVVPGIAAAVGVPAYAGVPLRDAEGADVRFVDARTASDRCWNEVGASDGTVVVS
TSLDSVAAAAGELVSAGRKPDTPMTVTVAGTTTRQRTWTATLGTIAQVLKQAKVLPSPDG
GQPVIVVVGERSAAAQRDQLSWFESKPLFGWRVLVPRTKEQAASLSDQLRSYGAVPHEVP
TIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVKAVREKFEEYGLDARAFAGIKVAA
VGEQTAAALIAFGVKPDLVPSGEQSAAGLLEDWPPYDPVFDPIDRVFLPRADIATETLVA
GLIDLGWEVDDVTAYRTVRASPPPAETREAIKGGGFDAVLFTSSSTVRNLVGIAGKPHNV
TVIACIGPATAKTAEEHGLRVDVMAPEPSVHKLAEALAEFGSRRRAAALEAGDPVTRPSE
RRPGSRRRRTAP
NT seq
1659 nt
NT seq
+upstream
nt +downstream
nt
ttgagccccacctcgaactttcccggcactcccgcacacgggcacgtcaccttcctgggt
gccggacccggagatccgggactgctgaccctgcgcgccgtcgaggcgctggcccgagcg
gatgtgctgatcgccgagcccgatgtgctcgacgtcgtccgcgtgcacgccaggggaggt
gtggacacaccccgggcagcggcagttgacgacgcgtcagctgccgtggacgcgccttcc
gcgcgagccgccgccaatcttgtcatggaggccgcgaggggcggcaggcgggtcgtgcgc
gcggtcagcggcgatccgggcctcgacacctacgcggcgggcgagatgctcgcctgcgcc
gccgagggcatctccttcgaggtggtgcccggcatcgcggccgccgtcggcgtgcccgcc
tacgcgggtgtgccgctgcgcgacgcggagggcgcggacgtgcgcttcgtcgacgcccgt
acggcgtcggaccgttgctggaacgaggtgggcgcctcggacggcaccgtcgtcgtctcc
acgtcgctcgactcggtggccgcggccgccggtgagctggtgtccgcgggccgcaagccc
gacaccccgatgaccgtgacggtggccggtacgacgacgcgccagcgcacctggaccgcg
acgctcggcaccatcgcgcaggtgctcaagcaggccaaggtgctgccgtcgccggacggc
gggcagccggtcatagtcgtggtcggcgaacgctcggccgccgcccagcgcgaccagctg
tcgtggttcgagtcgaagccgctcttcgggtggcgcgtgctcgtgccgcgcacgaaggag
caggcggcctcgctctccgaccagctgcgttcgtacggcgcggtgccgcatgaggtgccg
accatcgcggtcgaaccgccgcgcacgccccagcagatggagcgcgcggtcaagggcctg
gtcacgggccgctacgagtggatcgccttcaccagcgtcaacgccgtcaaggcggtgcgc
gagaagttcgaggagtacgggctcgacgcgcgggccttcgccgggatcaaggtcgcggcc
gtcggcgagcagaccgccgccgcgctgatcgccttcggcgtgaagccggacctggtgccc
agcggcgagcagtcggccgccggactccttgaggactggccgccgtacgacccggtcttc
gacccgatcgaccgtgtcttcctgccgcgggccgacatcgccacggagaccctggtcgcg
ggcctgatcgacctcgggtgggaggtcgacgacgtcaccgcctaccggacggtgcgcgct
tcgccgcccccggccgagacgcgcgaggcgatcaagggcggtggcttcgacgccgttctc
ttcacctcttcgtcgaccgtgcggaacctcgtcggcatcgcgggcaagccgcacaacgtg
accgtgatcgcgtgcatcggcccggcgacggccaagaccgcggaggagcacgggctccgg
gtggacgtgatggctcccgagccgtcggtccacaagctggccgaggcgcttgccgagttc
gggtctcggcggagggctgcggcgctggaggcgggggatcccgtcacccggcccagtgag
cgtcggccggggtcccgtcggcgccgtaccgccccgtag
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